Comparison to Early Detect of the Sepsis

Comparison of National Early Warning Score (NEWS) & Sepsis Patient Evaluation in the Emergency Department (SPEED) for The Early Identification of Sepsis in the Emergency Department

The aim of the study was to identify co-variates associated with 30-day mortality in septic patients admitted to the emergency department in order to improve morbidity & mortality as a sequence of sepsis in Assiut & Suez Canal Universities by comparing both scores by utilizing parameters that are readily available .

Study Overview

• Status: Not yet recruiting
• Conditions: Sepsis Scores

Detailed Description

There are a relatively large number of conditions where urgent intervention is required in order to secure the best outcome for the patient. Examples include sepsis, myocardial infarction (MI). Clinical diagnosis of some of these conditions is not always straightforward, but a common theme is that many present with deranged physiology and vital signs. Implementation of an early warning score on arrival at hospital has helped to identify seriously ill patients .

There is a high mortality rate associated with severe infection at all ages Sepsis occurs when life-threatening organ dysfunction is associated with infection.

What is a national early warning score (NEWS)? The following six simple physiological parameters are included in the scoring system: respiratory rate, oxygen saturation, temperature; the normal human body temperature range is typically stated as 36.5-37 °C( ), systolic blood pressure, pulse rate & level of consciousness.

What is a sepsis patient evaluation in the emergency department (SPEED)? The following simple clinical, physiological and laboratory parameters are included in the scoring system : hypotension (systolic pressure <90 mmHg) hypothermia (body temperature <36.0°C) , hypoxemia (pulse oximetry <90%), low hematocrit (hematocrit <0.38), Acidosis (blood PH < 7.35), elevated blood lactate >2.4 mmol/L & source of infection as pneumonia.

• Study Type: Observational
• Enrollment (Anticipated): 120

Contacts and Locations

• Study Contact: Name: Mostafa H. Mostafa, GP; Phone Number: +201552590309; Email: moustafa.13212250@med.aun.edu.eg
• Study Contact Backup: Name: Fatma A. Abdelaal, professor; Phone Number: +201113221317; Email: Fatmaabdelal23@yahoo.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

all gender entering the emergency deparment from 18 years to 80 years with no acceptance of healthy volunteers .

Description

Inclusion Criteria:

• Age of 18 - 80 years.
• Patients of both genders.

Exclusion Criteria:

• Patient refusal .
• Accepts Healthy Volunteers .
• Aged below 18 years

Study Plan

How is the study designed?

Design Details

• Observational Models: Other
• Time Perspectives: Cross-Sectional

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality .	Mortality during the 30 day follow-up.	30 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hospital admission .	Admission to hospital from the Emergency Department.	Day 0
ICU/HDU admission .	Admission to the Intensive Care Unit or High Dependency Unit from the Emergency Department .	Day 0
Readmission in the ED .	Re-visits to the ED after the index-visit .	Hour 72, Day 30

Collaborators and Investigators

• Sponsor: Assiut University

Publications and helpful links

General Publications

• Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP. Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit. Am J Respir Crit Care Med. 2017 Apr 1;195(7):906-911. doi: 10.1164/rccm.201604-0854OC.
• Usman OA, Usman AA, Ward MA. Comparison of SIRS, qSOFA, and NEWS for the early identification of sepsis in the Emergency Department. Am J Emerg Med. 2019 Aug;37(8):1490-1497. doi: 10.1016/j.ajem.2018.10.058. Epub 2018 Nov 7.
• Bewersdorf JP, Hautmann O, Kofink D, Abdul Khalil A, Zainal Abidin I, Loch A. The SPEED (sepsis patient evaluation in the emergency department) score: a risk stratification and outcome prediction tool. Eur J Emerg Med. 2017 Jun;24(3):170-175. doi: 10.1097/MEJ.0000000000000344.

Study record dates

Study Major Dates

• Study Start (Anticipated): November 1, 2021
• Primary Completion (Anticipated): October 1, 2024
• Study Completion (Anticipated): February 1, 2025

Study Registration Dates

• First Submitted: October 24, 2021
• First Submitted That Met QC Criteria: October 24, 2021
• First Posted (Actual): November 4, 2021

Study Record Updates

• Last Update Posted (Actual): November 4, 2021
• Last Update Submitted That Met QC Criteria: October 24, 2021
• Last Verified: October 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Sepsis; Toxemia
• Other Study ID Numbers: sepsis identification

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No