- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05111392
Hydration Dynamics and Influence of Beverage Composition
July 13, 2023 updated by: Craig A. Horswill, University of Illinois at Chicago
The study examines interactions between fluid availability in the gut and fluid retention in the body.
The relative rate of fluid uptake, the expansion of the plasma volume, and percent of fluid retained by the body will be measured in response to ingestion of beverages of different composition.
Healthy, euhydrated adults will be studied.
The results will help establish formulations of beverages that sustain if not promote acute euhydration.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Using a randomized order for beverage treatments at three separate trials, subjects will ingest 1 Liter of one of three beverages in 10 minutes: water, a beverage with 2.5% glucose with 45 mmol sodium/L, or a beverage with 1.7% glucose with 60 mmol sodium/L.
Before and repeatedly for 2 h after ingestion of the beverage, blood samples will be drawn for assessments of D2O, Hb, Hct, osmolality, sodium, and glucose.
The rate of appearance of D2O will be evaluated using the area under the curve, the slope of the appearance, and half time to plateau.
Comparisons will be made between beverages for indices of the rate of appearance of D2O, the change in PV over time, and cumulative urine excreted.
The cumulative urine produced will be used to calculate a modified BHI for the two glucose-electrolyte beverages and water for comparison with 1.0 (expected for no beverage effect).
We hypothesize faster absorption (D2O appearance rate), and better overall hydration (expanded PV and higher modified BHI) will occur for beverages containing glucose and sodium compared to water.
Further, we hypothesize that of the electrolyte beverages, the beverage with higher sodium content will promote greater overall hydration (less urine excreted) than the beverage with lower sodium.
Study Type
Interventional
Enrollment (Actual)
14
Phase
- Phase 2
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Craig A Horswill, PhD
- Phone Number: 312-996-5656
- Email: horswill@uic.edu
Study Locations
-
-
Illinois
-
Chicago, Illinois, United States, 60612
- University of Illinois Chicago
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 45 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Have a BMI of 18.5 to 29.9 kg/m2.
- Be normotensive (<120/80 mm Hg).
- Must be able to speak and read English.
- Be physically active or a regular exerciser but be able to abstain from exercise for 48 h prior to each study trial.
- Fast for at least 8 hours prior to and through the study trial.
- Be able to abstain from alcohol for 48 h prior to each study.
- Be able to abstain from caffeine for 24 h prior to each study.
- If female, must have regular menstrual cycles, that are > 27 days and < 35 days in length.
Exclusion Criteria:
- Under 18 y of age or over 45 y of age.
- Have a BMI <18.5 or >30.
- Being pregnant.
- Lactating.
- Tobacco user.
- Have hypotension or hypertension.
- Have any type of kidney disease or dysfunction.
- Have diabetes.
- Have any type of cardiovascular disease.
- Have been diagnosed with galactosemia.
- Females with irregular menstrual cycles.
- Females with polycystic ovary disease.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
Water
|
Ingestion of one (1) liter of beverage with observation for 2 h
|
Experimental: Oral rehydration solution 1
Beverage with 2.5% glucose with 45 mmol sodium/L.
|
Ingestion of one (1) liter of beverage with observation for 2 h
|
Experimental: Oral rehydration solution 2
Beverage with 1.7% glucose with 60 mmol sodium/L.
|
Ingestion of one (1) liter of beverage with observation for 2 h
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rate of appearance of deuterium in the plasma for placebo
Time Frame: 2 hours
|
Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo.
|
2 hours
|
Rate of appearance of deuterium in the plasma for oral rehydration solution 1.
Time Frame: 2 hours
|
Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo.
|
2 hours
|
Rate of appearance of deuterium in the plasma for oral rehydration solution 2.
Time Frame: 2 hours
|
Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo.
|
2 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Fluid retention for placebo
Time Frame: 2 hours
|
Measure fluid retention using the difference between ingested volume and cumulative urine excretion as a percentage of the ingested volume.
|
2 hours
|
Fluid retention for oral rehydration solution 1
Time Frame: 2 hours
|
Measure fluid retention using the difference between ingested volume and cumulative urine excretion as a percentage of the ingested volume.
|
2 hours
|
Fluid retention for oral rehydration solution 2
Time Frame: 2 hours
|
Measure fluid retention using the difference between ingested volume and cumulative urine excretion as a percentage of the ingested volume.
|
2 hours
|
Change in plasma volume for placebo
Time Frame: 2 hours
|
Increase in plasma volume (water content of the blood) following ingestion of beverage
|
2 hours
|
Change in plasma volume for oral rehydration solution 1
Time Frame: 2 hours
|
Increase in plasma volume (water content of the blood) following ingestion of beverage
|
2 hours
|
Change in plasma volume for oral rehydration solution 2
Time Frame: 2 hours
|
Increase in plasma volume (water content of the blood) following ingestion of beverage
|
2 hours
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Craig A Horswill, PhD, University of Illinois at Chicago
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 3, 2021
Primary Completion (Actual)
October 31, 2022
Study Completion (Actual)
November 30, 2022
Study Registration Dates
First Submitted
November 4, 2021
First Submitted That Met QC Criteria
November 5, 2021
First Posted (Actual)
November 8, 2021
Study Record Updates
Last Update Posted (Actual)
July 14, 2023
Last Update Submitted That Met QC Criteria
July 13, 2023
Last Verified
July 1, 2023
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2021-0823
- Abbott Nutrition (EAS) (Other Grant/Funding Number: Non-Federal Industry)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
IPD Plan Description
If shared, the main outcome variables will be posted.
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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