Longevity in Russia

Healthy Longevity and Mortality in Long-living Adults: Contributors and Causes - Lifestyle, Socioeconomic Background, and Replicative Aging

This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.

The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity.

The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.

Study Overview

• Status: Recruiting
• Conditions: Frailty; Aging; Aging Disorder; Age-related Cognitive Decline; LONGEVITY 1

Detailed Description

The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva.

Follow-up checks will be carried out once a year by phone or during additional visits.

The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.

• Study Type: Observational
• Enrollment (Estimated): 4000

Contacts and Locations

• Study Contact: Name: Veronika V. Erema, M.D., Ph.D; Phone Number: 4136 +7 (495) 540-61-71; Email: VErema@cspfmba.ru
• Study Contact Backup: Name: Daria A. Kashtanova, M.D., Ph.D; Phone Number: 4120 +74955406171; Email: DKashtanova@cspfmba.ru

Study Locations

• Russian Federation
  • Moscow, Russian Federation, 129226
    • Recruiting
    • RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation
    • Contact: Irina D. Strazhesko, M.D., Ph.D; Phone Number: +7 (499) 187-64-67; Email: Istrazhesko@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

The inclusion of participants will be carried out with the involvement of social services, boarding houses for labor veterans, geriatric centers and other geriatric services in the central region of Russia

Description

Inclusion Criteria:

• Informed consent
• 90 years of age or above

Exclusion Criteria:

• Refusal to participate or to provide informed consent;
• Any other criteria deemed reasons for exclusion by the Principal Investigator.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Long-living individuals; Long-living individuals at least 90 years of age from the Central Federal District of Russia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality among long-living adults	Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed.	at least 1 year after inclusion in the study
Morbidity among long-living adults	Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed.	at least 1 year after inclusion in the study

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Aging phenotypes	Identification of successful and unsuccessful aging phenotypes	at least 2 years after inclusion in the study
Social, economic, and medical- history-related determinants	Identification of social, economic, and medical- history-related determinants of successful and unsuccessful aging, geriatric syndromes	at least 2 years after inclusion in the study
Genetic determinants	Identification of the genetic determinants of successful and unsuccessful aging, geriatric syndromes	at least 2 years after inclusion in the study
Epigenetic determinants	Identification of the epigenetic determinants (methylation sites) of successful and unsuccessful aging, geriatric syndromes	at least 2 years after inclusion in the study
Metagenomic determinants	Identification of the metagenomic determinants (16S-rSeq) of successful and unsuccessful aging, geriatric syndromes	at least 2 years after inclusion in the study

Collaborators and Investigators

• Sponsor: Center for Strategic Planning, of the Federal Medical and Biological Agency
• Collaborators: Pirogov Russian National Research Medical University
• Investigators: Principal Investigator: Irina D. Strazhesko, M.D., Ph.D, Pirogov Russian National Research Medical University

Study record dates

Study Major Dates

• Study Start (Actual): December 25, 2019
• Primary Completion (Estimated): December 31, 2024
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: February 13, 2024
• First Submitted That Met QC Criteria: February 13, 2024
• First Posted (Actual): February 20, 2024

Study Record Updates

• Last Update Posted (Estimated): February 22, 2024
• Last Update Submitted That Met QC Criteria: February 20, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction; Frailty
• Other Study ID Numbers: MLS90

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No