Thyroid and Cortisol Hormone Response to Sepsis
Thyroid and Cortisol Hormone Response in Patients With Sepsis Who Attended To Assiut University Hospitals (ICU)
Study Overview
Status
Conditions
Detailed Description
Sepsis is dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents.
Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance.
In response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. Production and secretion of stress hormones increase to modulate behaviour Many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. However, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (TSH) and inhibition of the peripheral conversion of thyroxine (T4) by 5-deiodinase to the much more metabolically active triiodothyronine (T3). High cortisol levels also inhibit this enzymatic conversion.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Sara Mahmoud khalf allah Mohamed
- Phone Number: 01099929480
- Email: saramm302@gmail.com
Study Contact Backup
- Name: Mohamed Hossam Aldin Hassan, Professor
- Phone Number: 01006261166
- Email: hossammaghraby@yahoo.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
include Adults (≥18 years), both genders, admitted to critical care unit with sepsis
Exclusion patient with Previous diagnosis of endocrinal changes (thyroid dysfunction , hypopituitarism, Addison disease, Cushing syndrome)
Description
Inclusion Criteria:
- The study will include Adults (≥18 years), both genders
- septic patients admitted to critical care unit
Exclusion Criteria:
- thyroid disease
- hypopituitarism
- Addison disease
- Cushing syndrome)
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Pattern of cortisol level and thyroid function response to sepsis in ICU
Time Frame: From time of admission to ICU up to 3rd day after discharge
|
Affect of sepsis on hormones at ICU:compare the change of endocrinal hormones ( TSH (mIU/L) .T3(ng/dL) .T4 ( mcg/dL) adrenocorticotropic hormone "ACTH" (pg/mL) , cortisol (µg/dL)) at time of admission, course ICU ,3rd day after discharge
|
From time of admission to ICU up to 3rd day after discharge
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Thyroid and cortisol in sepsis
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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