Safety and Efficacy Study of IVB103 Injection in Subjects With Neovascular (Wet) Agerelated Macular Degeneration (nAMD).

An Exploratory Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of IVB103 Injection in Subjects With Neovascular (Wet) Agerelated Macular Degeneration (nAMD).

The goal of this clinical trial is to evaluate the safety and efficacy of IVB103 injection in subjects with nAMD.

Study Overview

• Status: Enrolling by invitation
• Conditions: nAMD
• Intervention / Treatment: Genetic: IVB103 Injection（Low dose）; Genetic: IVB103 Injection（Intermediate dose）; Genetic: IVB103 Injection（High dose）

Detailed Description

This is an open-label, non-randomized, multi-center dose escalation study. One eye of each participant will receive a single IVB103 injection by intravitreal injection. Participants will be followed for 52 weeks after which they will continue to be followed for up to 5 years after enrollment.

• Study Type: Interventional
• Enrollment (Estimated): 18
• Phase: Phase 1

Contacts and Locations

Study Locations

• China
  • Sichuan
    • Chengdu, Sichuan, China, 610000
      • West China Hospital of Sichuan University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Subjects voluntarily participate and sign the informed consent form;
2. Age≥ 50 years old, gender is not limited;
3. Confirmed presence of active CNV secondary to nAMD in the macula of study eye;
4. The total area of all types of lesions in the study eye < 30 mm2;
5. The Best Corrected Visual Acuity (BCVA) detected by the Early Treatment Diabetic Retinopathy Study (ETDRS) eye chart in the study eye is 63~19 letters (including boundary values), which is equivalent to 20/63 to 20/400 of the Snellen Eye Chart;
6. The BCVA detected by the ETDRS eye chart in the non-study eye is not less than 19 letters, which is equivalent to 20/400 of the Snellen Eye Chart;
7. The study eye has received at least 2 episodes of intravitreal anti- VEGF therapy within 6 months prior to screening and has responded within two weeks of the lead-in period of anti-VEGF standard therapy (Aflibercept injection);
8. At screening, the blood pregnancy test result of females of childbearing potential (e.g., females who have not undergone surgical sterilization or less than 1 year after menopause) is negative. Male and female subjects of childbearing potential agree to use effective contraception throughout the study and for at least 12 months after dosing.

Exclusion Criteria:

Study Eye：

1. Opacity of refractive media or inability to dilate pupils in the study eye that significantly interferes with visual acuity detection, anterior segment or fundus assessment;
2. Presence of retinal hemorrhage, geographic atrophy, scarring or fibrosis, dense subfoveal hard exudate, retinal pigment epithelium (RPE) tear involving the fovea in the study eye;
3. The study eye is combined with ocular diseases that affect central vision (e.g., diabetic retinopathy, retinal vein occlusion, vascular streaks, pathological myopia, retinal detachment, macular hole, epimacular membrane, toxoplasmosis, optic nerve disease, central serous choroidopathy, Inherited Retinal Diseases(IRDs), etc.);
4. Active intraocular or periocular infection (such as blepharitis, conjunctivitis, keratitis, scleritis, etc.) in the study eye;
5. Patients with glaucoma and ocular hypertension (intraocular pressure ≥ 25mmHg during the screening period) in the study eye;
6. Subjects with a history of intravitreal procedures other than anti- VEGF administration within the last six months (e.g., vitrectomy, macular translocation, trabecular meshwork removal, or other filtration surgery;
7. History of laser or photodynamic therapy for nAMD;
8. Presence of an ocular implant in the study eye (excluding intraocular lens, custom flex iris prosthesis); Either eye：
9. History of uveitis in either eye; Systemic diseases and others：
10. Those with diffuse intravascular coagulation and obvious bleeding tendency (such as hemoptysis, hematemesis, severe purpura, etc.) within 3 months before screening;
11. History of myocardial infarction, unstable angina, coronary revascularization, cerebrovascular accident (including TIA), history of other thromboembolic diseases (such as thromboembolic angiitis, pulmonary embolism, deep vein thrombosis, portal vein thrombosis, etc.), New York Heart Association (NYHA) grade ≥ II cardiac insufficiency, severe unstable ventricular arrhythmia, within 6 months prior to screening;
12. Have contraindications to transient immunosuppression of systemic prophylaxis (including but not limited to tuberculosis, osteoporosis, peptic ulcer, severe affective disorder) or immunocompromised;
13. Patients with systemic immune diseases (including systemic lupus erythematosus, ankylosing spondylitis, rheumatoid arthritis, etc.);
14. Diabetic patients with any of the following conditions: Known macrovascular complications; Glycosylated hemoglobin at screening（HbA1c）>7.5%; Those who have received more than two oral hypoglycemic drugs or received insulin or GLP-1 receptor agonists therapies;

15. Hypertensive patients with poor blood pressure control (defined as:

    systolic blood pressure ≥ 160 mmHg or diastolic blood pressure

    ≥100 mmHg when the subject is seated after receiving antihypertensive medication);

16. Any uncontrollable clinical illness (such as severe psychiatric, respiratory and other systemic diseases and history of malignant tumors);
17. Patients with abnormal liver and kidney function: alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ≥ 2 times the upper limit of normal; Total bilirubin ≥ 1.5 times the upper limit of normal, creatinine and urea/urea nitrogen ≥ 1.5 times the upper limit of normal;
18. Patients with abnormal coagulation function: prothrombin time (PT) > upper limit of normal value of 3 seconds or activated partial thromboplasting time (APTT) > upper limit of normal value of 10 seconds; Haemoglobin (HGb) < 10 g/dL;
19. Those who are positive for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, treponema pallidum antibody and human immunodeficiency virus (HIV) antibody;
20. AAV neutralizing antibody titer >1:1000;
21. Those who are known to be allergic to the therapeutic drugs or diagnostic drugs used in the study protocol, including the investigational products, fluorescein sodium, indocyanine green, etc.;
22. Those who have used anticoagulant or antiplatelet drugs within 14 days before dosing;

23. Currently using or may need to use drugs that can cause crystal toxicity or retinal toxicity (such as deferrigin, chloroquine

    /hydroxychloroquine, tamoxifen, ethambutol, etc.);

24. Those who have a history of surgical operation within 1 month before screening, and/or currently have unhealed wounds (wound degree> stage III), moderate to severe ulcers, and fractures;
25. Patients with systemic infectious diseases requiring systemic treatment (oral, intramuscular or intravenous) at the time of screening;
26. Those who have received any AAV gene therapy products in the past;
27. Pregnant or lactating females;
28. Those who have participated in any clinical trial of drugs (excluding vitamins and minerals) within 3 months before screening;
29. Other those who need to be excluded in the opinion of the investigator.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: IVB103 Treatment Arm（Low dose）; Intraocular injection of a single low dose of IVB103	Genetic: IVB103 Injection（Low dose）; Single intravitreal injection
Experimental: IVB103 Treatment Arm（Intermediate dose）; Intraocular injection of a single intermediate dose of IVB103	Genetic: IVB103 Injection（Intermediate dose）; Single intravitreal injection
Experimental: IVB103 Treatment Arm（High dose）; Intraocular injection of a single high dose of IVB103	Genetic: IVB103 Injection（High dose）; Single intravitreal injection

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of DLTs	Number and proportion of dose limited toxicity（DLTs）	4 weeks
Incidence of AEs	Number and severity of overall and ocular Adverse Events (AEs)	52 weeks
Incidence of SAEs	Number and severity of overall and ocular Serious Adverse Events (SAEs)	52 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Visual function	Change from baseline in BCVA(Best Corrected Visual Acuity)(ETDRS)	52 weeks
OCT imaging	Change from baseline in CST(Central Retinal Thickness)(OCT)	52 weeks
the number of anti-VEGF remedy therapy	the number of anti-VEGF remedy therapy within 52 weeks after dosing;	52 weeks
mean annualized anti-VEGF injection rate	change in mean annualized anti-VEGF injection rate	52 weeks

Collaborators and Investigators

• Sponsor: InnoVec Biotherapeutics Inc.
• Collaborators: NeoVec Biotherapeutics Inc.

Study record dates

Study Major Dates

• Study Start (Actual): April 22, 2025
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2031

Study Registration Dates

• First Submitted: December 11, 2024
• First Submitted That Met QC Criteria: December 15, 2024
• First Posted (Actual): December 17, 2024

Study Record Updates

• Last Update Posted (Actual): April 30, 2025
• Last Update Submitted That Met QC Criteria: April 28, 2025
• Last Verified: April 1, 2025

More Information

Terms related to this study

• Keywords: Retinal Disease; nAMD
• Additional Relevant MeSH Terms: Eye Diseases; Retinal Diseases; Retinal Degeneration; Macular Degeneration
• Other Study ID Numbers: IVB103-C101

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No