Efficacy Evaluation of Avance QQ Collagen for Skin Beautification

To assess Avance QQ Collagen product on skin condition improvement

Study Overview

• Status: Completed
• Conditions: Skin Condition; Liposomal Encapsulation
• Intervention / Treatment: Dietary supplement: Placebo drink; Dietary supplement: Non-liposomal collagen drink; Dietary supplement: Liposomal collagen drink

• Study Type: Interventional
• Enrollment (Actual): 75
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Pingtung, Taiwan, 928
    • Chia Nan University of Pharmacy & Science

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy male or female adults, age above 18 years old;
• The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023));
• Commitment not to use products having activity comparable with that of the product to be tested during the study period;
• Free of any dermatological or systemic disorder that would interfere with results.

Exclusion Criteria:

• Subject with obvious skin surface damage;
• Subject who had oral or topical medication which may affect skin condition within 1 month;
• Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product;
• Female who is pregnant, nursing or planning to become pregnant during the course of the study;
• Received facial laser therapy, chemical peeling in the past 2 months.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo drink	Dietary supplement: Placebo drink; consume 50 g liquid drink daily for 8 consecutive weeks
Active Comparator: Non-liposomal collagen drink	Dietary supplement: Non-liposomal collagen drink; consume 50 g liquid drink daily for 8 consecutive weeks
Experimental: Liposomal collagen drink	Dietary supplement: Liposomal collagen drink; consume 50 g liquid drink daily for 8 consecutive weeks; Other Names: Avance QQ Collagen

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin elasticity	Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units	Change from Baseline skin elasticity at 8 weeks
The change of skin collagen density	DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units	Change from Baseline skin collagen density at 8 weeks
The change of skin wrinkles	VISIA Complexion Analysis was utilized to measure skin wrinkles. Units: the amount of detectable wrinkles	Change from Baseline skin wrinkles at 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of wrinkles around the eyes	VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles	Change from Baseline wrinkles around the eyes at 8 weeks
The change of skin hydration	Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120.	Change from Baseline skin hydration at 8 weeks
The change of skin lightness	Chroma Meter MM500 was utilized to measure face skin lightness. Units: L* index	Change from Baseline skin lightness at 8 weeks
The change of skin tone	Chroma Meter MM500 was utilized to measure face skin color. Units: Individual Typology Angle (ITA°)	Change from Baseline skin tone at 8 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of self-assessment skin condition	A self-assessment questionnaire was collected and evaluate skin condition.	Change from Baseline skin condition at 8 weeks

Collaborators and Investigators

• Sponsor: TCI Co., Ltd.
• Investigators: Principal Investigator: Chia-Hua Liang, Ph.D., Chia Nan University of Pharmacy & Science

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2024
• Primary Completion (Actual): January 24, 2025
• Study Completion (Actual): February 28, 2025

Study Registration Dates

• First Submitted: January 8, 2025
• First Submitted That Met QC Criteria: January 8, 2025
• First Posted (Actual): January 13, 2025

Study Record Updates

• Last Update Posted (Actual): April 13, 2025
• Last Update Submitted That Met QC Criteria: April 9, 2025
• Last Verified: April 1, 2025

More Information

Terms related to this study

• Keywords: Avance QQ Collagen; Double Nutri
• Additional Relevant MeSH Terms: Skin Diseases
• Other Study ID Numbers: 24-088-B

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No