Effects of Oral Collagen Drinks on Human Skin

The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.

Study Overview

• Status: Recruiting
• Conditions: Skin Condition; Collagen Synthesis
• Intervention / Treatment: Dietary supplement: Collagen Drink; Dietary supplement: MAXI Collagen Drink; Dietary supplement: MAXI Collagen Drink_High dose

Detailed Description

This study is a single-center, double-blinded, parallel human trial designed to evaluate the skin beauty effect of oral collagen drink and MAXI collagen drink.

Healthy adult participants aged 18-60 years will be enrolled. Participants will be informed to consume test samples daily for 4 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 1 week, and 4 weeks of consumption.

• Study Type: Interventional
• Enrollment (Estimated): 99
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Ping Lin; Phone Number: +886-02-87977811; Email: candice.lin@tci-bio.com

Study Locations

• China
  • Beijing, China
    • Recruiting
    • Beijing Ewish Testing Technology Co.,ltd.
    • Contact: PAN YAO; Phone Number: +86-13522777985; Email: Panyao@btbu.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy Chinese subjects aged 18 to 60 years, both male and female.
• Wrinkle Severity: Crow's feet graded 2-4; under-eye fine lines graded 2-5; nasolabial folds graded 1-3.
• Presence of facial skin laxity and sagging.
• Ability to undergo skin examinations and pre-treatment in the designated test areas.
• Ability to understand the trial process, participate voluntarily, and sign a written Informed Consent Form (ICF).

Exclusion Criteria:

• Pregnant or lactating women, or those planning to become pregnant in the near future.
• Highly sensitive constitution, history of allergic diseases, or history of allergies to cosmetics.
• Presence of skin diseases (e.g., psoriasis, eczema, atopic dermatitis, severe acne) or other chronic systemic diseases.
• Skin conditions in the test area such as birthmarks, hyperpigmentation, inflammation, scars, nevi (moles), or hypertrichosis (excessive hair).
• Use of anti-inflammatory drugs (e.g., oral or topical corticosteroids) within the past month.
• Use of cosmetics or other products with similar efficacy within the past 2 weeks.
• Participation in other human clinical trials for cosmetics within the past month.
• Any other conditions deemed unsuitable for participation based on clinical assessment.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Collagen Drink; oral intake 5 g collagen daily	Dietary supplement: Collagen Drink; consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 5 g Collagen Powder
Experimental: MAXI Collagen Drink; oral intake 15 mL MAXI collagen daily (equivalent to 5 g of deep hydrolyzed collagen net weight)	Dietary supplement: MAXI Collagen Drink; consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 15 mL MAXI Collagen Liquid (equivalent to 5 g of deep hydrolyzed collagen net weight)
Experimental: MAXI Collagen Drink_High dose; oral intake 30 mL MAXI collagen daily (equivalent to 10 g of deep hydrolyzed collagen net weight)	Dietary supplement: MAXI Collagen Drink_High dose; consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 30 mL MAXI Collagen Liquid (equivalent to 10 g of deep hydrolyzed collagen net weight)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of collagen fiber fluorescence intensity	SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to evaluate the density and quality of dermal collagen fibers.	Change from Baseline collagen intensity at 4 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin elasticity	Cutometer® MPA580 (CK, Germany) was utilized to measure the gross elasticity of the skin using suction method.	Change from Baseline skin elasticity at 4 weeks
The change of skin firmness	Cutometer® MPA580 (CK, Germany) was utilized to measure skin firmness and the area under the suction curve.	Change from Baseline skin firmness at 4 weeks
The change of epidermal thickness	SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to measure the depth of the epidermal layer using optical imaging.	Change from Baseline epidermal thickness at 4 weeks
The change of cheek skin roughness	AEVA-HE (EOTECH, France) was utilized to measure the arithmetic average roughness (Ra value) of the cheek surface.	Change from Baseline skin roughness at 4 weeks
The change of the Dermal-Epidermal Junction (DEJ) structures	SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to assess the structural integrity and epithelial-connective tissue interface (ECTI) of the DEJ.	Change from Baseline DEJ status at 4 weeks
The change of nasolabial folds volume	AEVA-HE (EOTECH, France) was utilized to quantify the 3D morphological changes of the nasolabial folds volume.	Change from Baseline wrinkle parameters at 4 weeks
The change of nasolabial folds depth	AEVA-HE (EOTECH, France) was utilized to quantify the 3D morphological changes of the nasolabial folds depth.	Change from Baseline wrinkle parameters at 4 weeks
The change of crow's feet volume	AEVA-HE (EOTECH, France) was utilized to measure the severity of crow's feet volume.	Change from Baseline crow's feet parameters at 4 weeks
The change of crow's feet depth	AEVA-HE (EOTECH, France) was utilized to measure the severity of crow's feet depth.	Change from Baseline crow's feet parameters at 4 weeks
The change of the volume of fine lines under the eyes	AEVA-HE (EOTECH, France) was utilized to assess the volume of fine lines under the eyes.	Change from Baseline fine lines at 4 weeks
The change of the mean depth of fine lines under the eyes	AEVA-HE (EOTECH, France) was utilized to assess the mean depth of fine lines under the eyes.	Change from Baseline fine lines at 4 weeks
The change of cheek (malar) volume	AEVA-HE (EOTECH, France) was utilized to measure the 3D volume of the cheek area for lifting effects.	Change from Baseline cheek volume at 4 weeks
The change of jawline length	AEVA-HE (EOTECH, France) was utilized to measure the linear length and contour of the jawline.	Change from Baseline jawline parameters at 4 weeks
The change of skin pores counts	AEVA-HE (EOTECH, France) was utilized to perform 3D imaging and quantification of skin pores counts.	Change from Baseline pore parameters at 4 weeks
The change of skin pores volume	AEVA-HE (EOTECH, France) was utilized to perform 3D imaging and quantification of skin pores volume.	Change from Baseline pore parameters at 4 weeks
The change of skin hydration	Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydration. Units: arbitrary Corneometer® units 0-120.	Change from Baseline skin hydration at 4 weeks
The change of transepidermal water loss (TEWL)	Tewameter® TM300 (CK, Germany) was utilized to measure the evaporation rate of water from the skin. Units: g/h/m^2.	Change from Baseline TEWL at 4 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin brightness (L*)	Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin brightness (L*).	Change from Baseline skin brightness (L*) at 4 weeks
The change of skin individual typology angle (ITA)	Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin individual typology angle (ITA).	Change from Baseline skin ITA at 4 weeks
The change of skin color parameters	Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin redness (a*).	Change from Baseline skin redness (a*) at 4 weeks
The change of skin color parameters	Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin yellow tone (b*).	Change from Baseline skin yellow tone (b*) at 4 weeks

Collaborators and Investigators

• Sponsor: TCI Co., Ltd.
• Investigators: Principal Investigator: YAO PAN, Beijing Ewish Testing Technology Co.,ltd.

Study record dates

Study Major Dates

• Study Start (Actual): May 12, 2026
• Primary Completion (Estimated): June 15, 2026
• Study Completion (Estimated): June 30, 2026

Study Registration Dates

• First Submitted: May 8, 2026
• First Submitted That Met QC Criteria: May 18, 2026
• First Posted (Actual): May 26, 2026

Study Record Updates

• Last Update Posted (Actual): May 26, 2026
• Last Update Submitted That Met QC Criteria: May 18, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: Hydrolyzed collagen; MAXI Collagen; Oral Collagen
• Additional Relevant MeSH Terms: Skin and Connective Tissue Diseases; Skin Diseases
• Other Study ID Numbers: SECCR2025-254

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No