Prediabetes and Metabolic Parameters Among Young Adults at Assiut University Hospital

November 28, 2025 updated by: Heba Gamal Ali Mohamed, Assiut University

Prediabetes Among Young Adults and Its Relation to Metabolic Parameters in Persons Attending Assuit University Hospital

Prediabetes is a major public health problem that increases the risk of developing type 2 diabetes mellitus and cardiovascular complications. Young adults represent an important age group in which early detection and intervention may prevent progression of the disease. The present study aims to identify factors associated with prediabetes and metabolic complications, and classify individuals based on clinical and biochemical profiles according to insulin resistance, dyslipidemia and fatty liver. This is an observational, cross-sectional study that will be conducted at Assiut University Hospital. Data will be collected through clinical examination, laboratory investigations, and assessment of metabolic profiles.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

120

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

The study population will consist of young adults aged 18-40 years attending outpatient clinics at Assiut University Hospital. Participants will be screened for prediabetes using fasting plasma glucose, 2-hour postprandial glucose, and HbA1c tests. Only individuals diagnosed with prediabetes according to ADA criteria (impaired fasting glucose, impaired glucose tolerance, or elevated HbA1c) will be included

Description

Inclusion Criteria:

  • adults diagnosed with prediabetes

Exclusion Criteria:

  • previous diagnosis of overt diabetes
  • other causes of CKD (e.g. urinary tract infection)
  • other causes of liver disease (e.g. HBV infection),
  • use of medications that alter glucose or lipid metabolism (e.g. corticosteroids),
  • current pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Group A impaired glucose tolerance_Group B - Impaired Fasting Glucose Group C - Impaired HbA1c
Other: No intervention
Participants will be classified into groups based on impaired fasting glucose, impaired post-prandial glucose, or impaired HbA1c according to ADA criteria

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation between prediabetes subtypes and metabolic syndrome
Time Frame: At baseline (cross-sectional assessment during enrollment).

Primary Outcome

Title:

Correlation between prediabetes phenotypes and metabolic syndrome

Outcome Measure:

Prevalence (%) of metabolic syndrome within each prediabetes phenotype (IFG, IGT, combined IFG/IGT, elevated HbA1c).

Description:

Metabolic syndrome will be assessed at baseline according to the IDF definition. Participants will be classified into prediabetes phenotypes, and the proportion of individuals meeting metabolic syndrome criteria within each phenotype will be recorded.

Time Frame:

Baseline

Unit of Measure:

Percentage (%)
At baseline (cross-sectional assessment during enrollment).

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Factors affecting the correlation between prediabetes phenotypes and metabolic abnormalities (age, gender, family history, body physique, waist circumference and physical activity.
Time Frame: At baseline (cross-sectional assessment during enrollment)
Secondary Outcome 1 Title: Age Description: Participant age in years. Unit of Measure: Years Time Frame: Baseline Secondary Outcome 2 Title: Sex Description: Participant sex as recorded at baseline. Unit of Measure: Categorical Time Frame: Baseline Secondary Outcome 3 Title: Family history of diabetes Description: Presence of family history of diabetes in first-degree relatives. Unit of Measure: Yes/No Time Frame: Baseline Secondary Outcome 4 Title: Weight Description: Body weight measured using a calibrated scale. Unit of Measure: Kilograms Time Frame: Baseline Secondary Outcome 5 Title: Height Description: Participant height measured using a stadiometer. Unit of Measure: Centimeters Time Frame: Baseline Secondary Outcome 6 Title: Body Mass Index (BMI) Description: BMI calculated as weight (kg) divided by height squared (m²). Unit of Measure: kg/m² Time Frame: Baseline Secondary Outcome 7 Title: Waist circumference Description: Waist circumference measured using a non-stretchab
At baseline (cross-sectional assessment during enrollment)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • http://doi.org/10.1007/s00125-013-2902-4
  • http://doi.org/10.1136/bmj.g4485
  • http://doi.org/10.1007/s00125-009-1443-3
  • http://doi.org/10.2337/dc08-1264
  • http://doi.org/10.1016/j.diabres.2007.05.004
  • http://doi.org/10.2337/diabetes.52.6.1475
  • http://doi.org/10.1136/bmj.i5953
  • http://doi.org/10.1056/NEJMoa012512
  • http://doi.org/10.1016/S0140-6736(12)60525-X
  • http://doi.org/10.2337/dc10-0679
  • http://doi.org/10.2337/diacare.2951130
  • http://doi.org/10.2337/dc07-9920
  • http://doi.org/10.1016/S0140-6736(12)60283-9
  • International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: IDF; 2021. http://www.diabetesatlas.org

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 1, 2025

Primary Completion (Estimated)

December 1, 2027

Study Completion (Estimated)

February 1, 2028

Study Registration Dates

First Submitted

September 14, 2025

First Submitted That Met QC Criteria

November 28, 2025

First Posted (Actual)

December 2, 2025

Study Record Updates

Last Update Posted (Actual)

December 2, 2025

Last Update Submitted That Met QC Criteria

November 28, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AUH-MED-PREDIAB-2025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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