Use of Subanesthetic Dose Propofol Before Extubation

December 10, 2025 updated by: Nureddin YUZKAT, Yuzuncu Yil University

Effect of Subanesthetic Dose Propofol Use Before Extubation on Recovery From Anesthesia, Agitation on Recovery, and Patient Satisfaction

This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This study aims to evaluate whether administering a sub-anesthetic dose of propofol before extubation can reduce emergence agitation, enhance recovery characteristics, and improve patient comfort in adults undergoing rhinoplasty surgery. Emergence agitation is a common phenomenon during early recovery from general anesthesia and can involve restlessness, disorientation, and involuntary movements, potentially affecting patient safety and surgical outcomes. The study uses a randomized controlled design to compare peri-extubation responses between patients receiving low-dose propofol and those receiving standard care.

Study Type

Interventional

Enrollment (Actual)

80

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
      • Van, Turkey (Türkiye), 65080
        • Yuzuncu Yil University, Dursun Odabas Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Ages 18-65 years
  • Patients scheduled for rhinoplasty surgery
  • ASA physical status I-II
  • No respiratory tract infection
  • Provided written informed consent

Exclusion Criteria:

  • Refusal to participate
  • Presence of any respiratory tract infection
  • Younger than 18 or older than 65
  • ASA III-IV
  • Known allergy to study medications
  • Predicted difficult intubation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Propofol Group
Sub-anesthetic dose of propofol (0.5 mg/kg) administered 10 minutes before extubation.
Other: Normal Saline (Placebo)
Participants receive an equivalent volume of normal saline 10 minutes before extubation.
Sham Comparator: Control Group
Normal saline administered 10 minutes before extubation.
Drug: Propofol (Sub-Anesthetic Dose)
Participants receive 0.5 mg/kg intravenous propofol as a single bolus 10 minutes before extubation.
Other Names:
  • Normal saline administered pre-extubation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changing Preoperative Anxiety Score (STAI)
Time Frame: 15 minutes (T1-T2)
Comparison of the State-Trait Anxiety Inventory (STAI) state anxiety score measured in the preoperative waiting room (T1) with the STAI score 15 minutes after the palming technique (T2). The difference between the two time points is analyzed to assess the anxiety-reducing effect of the intervention.
15 minutes (T1-T2)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Hemodynamic Parameter Changes
Time Frame: 15 minutes (T1-T2)
Changes in heart rate (HR) values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.
15 minutes (T1-T2)
Hemodynamic Parameter Changes
Time Frame: 15 minutes (T1-T2)
Changes in mean blood pressure values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.
15 minutes (T1-T2)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Yuzuncu Yil University

Investigators

  • Principal Investigator: Nureddin Yuzkat, Associate professor, Yuzuncu Yil University Dursun Odabas Medical Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2024

Primary Completion (Actual)

September 1, 2024

Study Completion (Actual)

October 1, 2024

Study Registration Dates

First Submitted

November 16, 2025

First Submitted That Met QC Criteria

December 10, 2025

First Posted (Actual)

December 11, 2025

Study Record Updates

Last Update Posted (Actual)

December 11, 2025

Last Update Submitted That Met QC Criteria

December 10, 2025

Last Verified

May 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Subanesthetic Dose of Propofol

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be made available because data sharing was not included in the informed consent and sharing such data could compromise patient confidentiality.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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