Beta Caryophyllene & Apnea Performance

April 27, 2026 updated by: Chih-Hui Chiu

Effects of Beta Caryophyllene Supplementation on Autonomic Regulation and Apnea Performance in Elite Divers - a Randomized Crossover Trial

The purpose of this study is to investigate whether β-caryophyllene supplementation can enhance the static apnea capacity of freedivers.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Using a randomized crossover design with double-blind methodology, participants were assigned to either the β-caryophyllene trial (BCP) trial or the placebo (PLA) trial, which without β-caryophyllene. Participants consumed either 200 mg of β-caryophyllene capsules (BCP trial) or placebo capsules (PLA trial) based on pre-test results. After a 30-minute rest period and warm-up, a single maximal voluntary static breath-hold test was conducted. Breath-hold duration and physiological and salivary biochemical indicators before and after the breath-hold test were observed.

Study Type

Interventional

Enrollment (Actual)

15

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
      • Taichung, Taiwan
        • National Taiwan University of Sport

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • With over 3 years of freediving experience

Exclusion Criteria:

  • Without over 3 years of freediving experience

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: placebo
Dietary supplement: interventions
supplementation of β-caryophyllene
Dietary supplement: Placebo
Participants consumed placebo capsules (PLA trial)
Experimental: intervention
supplementation β-caryophyllene
Dietary supplement: interventions
supplementation of β-caryophyllene
Dietary supplement: Placebo
Participants consumed placebo capsules (PLA trial)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Breath-hold duration
Time Frame: 30 minutes after intervention
Measure the duration of static breath-holding
30 minutes after intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chih-Hui Chiu

Collaborators

National Science and Technology Council, Taiwan

Investigators

  • Principal Investigator: Chih Hui Chiu, National Taiwan University of Sport

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 15, 2026

Primary Completion (Actual)

April 1, 2026

Study Completion (Actual)

April 26, 2026

Study Registration Dates

First Submitted

January 6, 2026

First Submitted That Met QC Criteria

January 6, 2026

First Posted (Actual)

January 14, 2026

Study Record Updates

Last Update Posted (Actual)

April 29, 2026

Last Update Submitted That Met QC Criteria

April 27, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 115-1 (Other Identifier: NTUS)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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