From Global Balance Metrics to Plane-Specific Signatures: Identifying Postural Instability Phenotypes in Females (APSI-MLSI)

April 7, 2026 updated by: Azza Mohammed, Cairo University

The main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females.

Study Overview

Status

Completed

Conditions

Healthy

Intervention / Treatment

Diagnostic test: observational study, one group, one shot assessment

Detailed Description

Postural stability is essential for functional performance and injury prevention, with directional control influenced by neuromuscular and anthropometric factors. Limited data exist on proportional stability patterns and their relationship with body mass index (BMI). Therefore, the main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females.

Study Type

Observational

Enrollment (Actual)

111

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Egypt
- Giza Governorate
  - Dokki, Giza Governorate, Egypt, 11432
    - Faculty of Physical Therapy, Cairo University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

A total of 111 healthy female participants were recruited for this study, representing a homogeneous sample of young adults, aged 20-29 years, reflecting a population within early adulthood, a stage typically characterized by optimal neuromuscular function and postural control capacity.

Description

Inclusion Criteria:

a relatively uniform and non-clinical population

Exclusion Criteria:

any history of neurological disorders, vestibular dysfunction, musculoskeletal injuries affecting the lower limbs or spine within the preceding six months
or any condition known to impair balance. Individuals with visual impairments not corrected by lenses
taking medications that could influence neuromuscular performance or postural control
those engaged in specialized balance training or high-level athletic activities were also excluded to minimize potential confounding effects.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
APSI Time Frame: one month	anterior-posterior stability index	one month
MLSI Time Frame: one month	Mediolateral stability index	one month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
BMI Time Frame: one months	body mass index	one months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Investigators

Principal Investigator: Azza M Abdelmohsen, professor, Cairo University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Zhang X, Ruan B, Gao Q. Dynamic postural stability indices in athletes: a case-control study on chronic ankle instability during multi-directional landing assessments. BMC Musculoskeletal Disorders. 2025 Dec;26(1):1093.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 12, 2024

Primary Completion (Actual)

September 25, 2024

Study Completion (Actual)

October 25, 2024

Study Registration Dates

First Submitted

March 27, 2026

First Submitted That Met QC Criteria

April 2, 2026

First Posted (Actual)

April 7, 2026

Study Record Updates

Last Update Posted (Actual)

April 8, 2026

Last Update Submitted That Met QC Criteria