Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers

May 3, 2026 updated by: sara Gamal Ahmed, Cairo University

Postoperative Pain and Sealer Extrusion Following Root Canal Treatment With Neosealer Flo and Ceraseal Bioceramic Sealers; a Randomized Clinical Trial

To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Molar teeth requiring root canal treatment
  2. Diagnosed with symptomatic irreversible pulpitis,
  3. Patients able to understand and use the VAS scale

Exclusion Criteria:

  1. Patients with systemic diseases affecting pain perception
  2. Use of analgesics within 12 hours before treatment
  3. Previously treated teeth
  4. Teeth with periapical abscess or swelling

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: nanosealer flo
bioceramic sealer
Procedure: root canal treatment
nanosealer flo bioceramic root canal sealer
Procedure: root canal treatment
cerseral bioceramic root canal sealer
Active Comparator: ceraseal
bioceramic sealer
Procedure: root canal treatment
nanosealer flo bioceramic root canal sealer
Procedure: root canal treatment
cerseral bioceramic root canal sealer

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
postoperative pain
Time Frame: 24 and 48 hours
postoperative pain will be measured using a visual analogue scale ( after being introduced and discussed with the patient) at 2 time points, pain will be categorized as no pain, moderate and severe.
24 and 48 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
sealer extrusion
Time Frame: immediate postoperatively
sealer extrusion will be measured radiographically using standardized digital periapical posttreatment radiographs via a blinded examiner and recorded as binary outcome: present/ absent.
immediate postoperatively

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

May 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 8, 2026

Study Registration Dates

First Submitted

April 26, 2026

First Submitted That Met QC Criteria

May 3, 2026

First Posted (Actual)

May 8, 2026

Study Record Updates

Last Update Posted (Actual)

May 8, 2026

Last Update Submitted That Met QC Criteria

May 3, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • NewENDO3.3.3

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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