Photobiomodulation Therapy (PBMT) for Accelerating Maxillary Canine Movement Using Two Wavelengths (650 nm and 976 nm): A Split-Mouth Randomized Controlled Clinical Trial (PBMT-CAN)

May 15, 2026 updated by: Almustafa Alhumadi, Kufa University
movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. The results may help determine whether low-level laser therapy can accelerate orthodontic tooth movement safely and effectively.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Photobiomodulation therapy (PBMT) has been proposed as a non-invasive adjunctive method to accelerate orthodontic tooth movement and reduce overall treatment duration. This split-mouth randomized clinical trial aims to evaluate and compare the effectiveness of two different laser wavelengths (650 nm and 976 nm) on the acceleration of maxillary canine movement during orthodontic treatment.

Participants requiring bilateral maxillary first premolar extraction and canine retraction as part of their orthodontic treatment will be included. Each patient will serve as their own control using a split-mouth design. One side will receive PBMT application during canine retraction, while the contralateral side will act as the control or receive an alternative wavelength according to the randomization protocol.

Orthodontic canine movement will be performed using standardized orthodontic mechanics under controlled force application. The primary outcome measure will be the rate of maxillary canine movement assessed at regular intervals. Secondary outcomes will include total treatment duration required for space closure and the influence of patient-related factors such as age and gender on treatment outcomes.

The study will compare the clinical effectiveness of 650 nm and 976 nm wavelengths in accelerating orthodontic tooth movement. Statistical analyses including paired t-tests, independent t-tests, and correlation analyses will be used to evaluate differences between groups and assess associations between demographic variables and treatment response.

The findings of this study may provide clinically relevant evidence regarding the effectiveness of PBMT in reducing orthodontic treatment time and improving treatment efficiency.

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Iraq
    • Najaf Governorate
      • Najaf, Najaf Governorate, Iraq, 54001
        • Orthodontic Clinic, College of Dentistry, University of Kufa

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • good oral hygiene and the absence of any medications affecting bone metabolism.

Exclusion Criteria:

  • systemic diseases, periodontal pathology, a history of previous orthodontic treatment, or the use of antibiotics or anti-inflammatory drugs during the study.[

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 650 nm PBMT
Participants receive photobiomodulation therapy using a 650 nm laser during maxillary canine retraction.
Device: 650 nm Photobiomodulation Therapy
Application of 650 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.
Experimental: 976 nm PBMT
Participants receive photobiomodulation therapy using a 976 nm laser during maxillary canine retraction.
Device: 976 nm Photobiomodulation Therapy
Application of 976 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Rate of Maxillary Canine Movement
Time Frame: 6 months
Measurement of the amount of maxillary canine movement during orthodontic retraction following application of photobiomodulation therapy using 650 nm and 976 nm wavelengths.
6 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation Between Age and Rate of Canine Retraction
Time Frame: 6 months
Assessment of the correlation between patient age (years) and rate of maxillary canine retraction measured in millimeters per month using digital caliper measurements on study models.
6 months
Difference in Rate of Canine Retraction Between Sexes
Time Frame: 6 months
Comparison of the rate of maxillary canine retraction (mm/month) between male and female participants measured using digital caliper measurements on study models.
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Kufa University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 5, 2025

Primary Completion (Actual)

March 6, 2026

Study Completion (Actual)

March 20, 2026

Study Registration Dates

First Submitted

May 12, 2026

First Submitted That Met QC Criteria

May 15, 2026

First Posted (Actual)

May 19, 2026

Study Record Updates

Last Update Posted (Actual)

May 19, 2026

Last Update Submitted That Met QC Criteria

May 15, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PBMT-CANINE-2026
  • KU-IRB-2026-1-2 (Other Identifier: Ethics committee number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be publicly shared in order to protect participant confidentiality and privacy.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Photobiomodulation Therapy

Clinical Trials on 650 nm Photobiomodulation Therapy

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Azerbaijan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe