Frequency of Platelets Transfusion & Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing CABG

Frequency of Platelets Transfusion and Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing Coronary Artery Bypass Grafting (CABG): A Retrospective Cohort

The goal of this retrospective cohort study Is to Primarily be platelet transfusion frequency and postoperative bleeding risk, analysis using descriptive and inferential statistics in all eligible patients admitted to the cardiac intensive care unit (CICU) for open-heart surgery were included of both gender, age group of 30-80 years. The main questions it aims to answer are:

• How was the frequency of platelet transfusion during the index admission evaluated?
• How was post-operative bleeding risk measured?
• What does 24-hour chest drain output indicate in this context?
• How was packed cell volume (PCV) transfusion used as an outcome measure?

Study Overview

• Status: Completed
• Conditions: Patients on Clopidogrel; Platelets Transfusion

Detailed Description

The Cardiac Intensive Care Unit (CICU) at a tertiary care facility in Karachi, Pakistan, served as the site of this retrospective cohort study. Every procedure adhered to institutional policies, and safe data management and de-identification preserved confidentiality. Consecutive sampling was employed due to the retrospective methodology, and the sample included all eligible CICU patients who had heart surgery during the study period. The study included patients on dual antiplatelet treatment (DAPT: aspirin and/or clopidogrel) with the last dose within five days before to surgery, as well as adults between the ages of thirty and eighty undergoing heart surgery with cardiopulmonary bypass (CPB).

• Study Type: Observational
• Enrollment (Actual): 227

Contacts and Locations

Study Locations

• Pakistan
  • Sindh
    • Karachi, Sindh, Pakistan, 7480 0
      • Aga Khan University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

All eligible patients admitted to the cardiac intensive care unit (CICU) for open-heart surgery were included.

Description

Inclusion Criteria:

• CICU patients who underwent cardiac surgery
• Adults aged 30-80 years undergoing cardiac surgery with cardiopulmonary bypass
• Patients who received dual antiplatelet therapy, last dose within 5 days before surgery

Exclusion Criteria:

• BMI > 40 kg/m²
• Repeat open-heart surgery (reoperation)
• Transferred open-chest procedures
• Active liver disease
• Chronic lung disease
• Dialysis dependence
• Intra-aortic balloon pump (IABP) in place pre- or post-operatively
• Major neurological deficit within the past 6 months
• Incomplete clinical records

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Frequency of platelet transfusion	The frequency of platelet transfusion during the hospital stay.	From the day 1 of admission till discharge or 30 days of admission

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to re-intubation	The number of times reintubation occurred, i.e. the endotracheal tube was reinserted.	30-60 seconds from laryngoscope insertion in the oral cavity tilldetection of end tidal carbon dioxide trace.

Collaborators and Investigators

• Sponsor: Aga Khan University
• Investigators: Principal Investigator: Khalid Siddiqui, MBBS-FCPS, Aga Khan University; Principal Investigator: Khalid Siddiqui, Aga Khan University

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2022
• Primary Completion (Actual): May 31, 2023
• Study Completion (Actual): June 30, 2023

Study Registration Dates

• First Submitted: March 25, 2026
• First Submitted That Met QC Criteria: May 18, 2026
• First Posted (Actual): May 20, 2026

Study Record Updates

• Last Update Posted (Actual): May 20, 2026
• Last Update Submitted That Met QC Criteria: May 18, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: Post-Operative Bleeding Risk in Patients
• Other Study ID Numbers: 2023-9576-27366

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No