Comparison of Interrupted Suturing Versus Continuous Suturing in Laparotomy Wound Closed.

May 15, 2026 updated by: Muhammad Aamir Latif

Comparison of Outcome of Emergency Laparotomy Wound Closed by Interrupted Suturing Versus Continuous Suturing.

Emergency laparotomy is associated with high morbidity, particularly due to wound dehiscence and infection. Choosing an optimal suturing technique can significantly impact patient outcomes, but data on the comparison of interrupted suturing with continuous suturing in emergency settings is limited. Therefore, the current study was planned, aiming to compare the outcome of emergency laparotomy wounds closed by interrupted suturing versus continuous suturing.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Interrupted suturing has been suggested to provide better tensile strength and allow for better healing by reducing tension across the wound. Several studies have reported a significantly lower incidence of wound dehiscence with interrupted suturing compared to continuous suturing. Additionally, interrupted suturing may lower the risk of wound infection by reducing bacterial migration along the suture line. Despite that, continuous suturing generally provides faster, more cost-effective wound closure with superior cosmetic outcomes and reduced short-term pain compared to interrupted sutures. If the study finds interrupted suturing to have superior outcomes, it could become the preferred method for emergency laparotomy closure, improving surgical success rates and patient recovery.

Study Type

Interventional

Enrollment (Actual)

184

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
    • Punjab Province
      • Rawalpindi, Punjab Province, Pakistan, 46000
        • Benazir Bhutto Hospital/Rawalpindi Medical University and Allied Hospitals

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients of either gender
  • Aged 18-60 years
  • Undergoing emergency laparotomy

Exclusion Criteria:

  • Unfit for surgery
  • History of diabetes
  • Immuno-compromised
  • Pregnant/lactating mothers
  • Malignancy
  • Very low or very high body mass index (< 15kg/m2 or > 30kg/m2)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group-A
Patients went through interrupted closure with Smead Jones technique using prolene 1.
Procedure: Interrupted Closure
Patients went through interrupted closure with Smead Jones technique using prolene 1.
Experimental: Group-B
Patients went through continuous closure with prolene 1.
Procedure: Continuous Closure
Patients went through continuous closure with prolene 1.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Wound dehiscence
Time Frame: 10 days
The frequency of patients who experienced spontaneous opening of the midline laparotomy sutures within 10 days of surgery was noted.
10 days
Wound infection
Time Frame: 10 days
The frequency of patients who showed the presence of pus or any discharge at the surgical wound site, which was accompanied by pain, fever, raised white blood cell count (> 11000), swelling, and erythema, was noted.
10 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Muhammad Aamir Latif

Investigators

  • Principal Investigator: Farhan Ahmed, Benazir Bhutto Hospital/Rawalpindi Medical University and Allied Hospitals, Rawalpindi
  • Study Director: Usman Qureshi, FCPS, Holy Family Hospital/Rawalpindi Medical University and Allied Hospitals, Rawalpindi

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 15, 2025

Primary Completion (Actual)

February 14, 2026

Study Completion (Actual)

February 14, 2026

Study Registration Dates

First Submitted

May 15, 2026

First Submitted That Met QC Criteria

May 15, 2026

First Posted (Actual)

May 22, 2026

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 15, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Dr-Farhan-Rawalpindi

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Data can be shared on a reasonable request.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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