The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury

May 21, 2026 updated by: Lanyue Zhu, Zhongda Hospital
The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

5000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Southeast University Zhongda Hospital (2013-2024), Nanjing First Hospital (2016-2024), and the First Affiliated Hospital of Anhui Medical University (2013-2023)

Description

Inclusion Criteria:

  • Undergoing non-cardiac surgery；
  • Adult；

Exclusion Criteria:

  • Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);
  • Surgery duration less than 60 minutes;
  • Weight < 30 kg or BMI > 35 kg/m2;
  • Patients who underwent reoperation within 7 days after surgery;
  • Surgeries not performed under general anesthesia;
  • ASA > IV;
  • No serum creatinine measurement available within 6 months before surgery (baseline value) or within 7 days after surgery;
  • Preexisting renal dysfunction or a diagnosis of chronic kidney disease before surgery (creatinine > 443 μmol/L);
  • No invasive blood pressure monitoring during the anesthesia induction period, or missing more than 25% of intraoperative invasive blood pressure data collection.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
HH
High induction blood pressure variability + High surgery blood pressure variability
HL
High induction blood pressure variability + Low surgery blood pressure variability
LH
Low induction blood pressure variability + High surgery blood pressure variability
LL
Low induction blood pressure variability + Low surgery blood pressure variability

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
AKI
Time Frame: Within 7 days after surgery.
AKI diagnosed according to KDIGO criteria within 7 days after surgery was the primary outcome event.
Within 7 days after surgery.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhongda Hospital

Collaborators

The First Affiliated Hospital of Anhui Medical University
Nanjing First Hospital, Nanjing Medical University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

December 1, 2026

Study Registration Dates

First Submitted

May 15, 2026

First Submitted That Met QC Criteria

May 15, 2026

First Posted (Actual)

May 22, 2026

Study Record Updates

Last Update Posted (Actual)

May 27, 2026

Last Update Submitted That Met QC Criteria

May 21, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2025ZDSYLL420

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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