Impact of Traumatic Brain Injury on Cognitive Function, Balance and Functional Independence in Children (Impact TBI)

May 23, 2026 updated by: Nourhan mohamed baiomy, Cairo University

Impact of Traumatic Brain Injury on Cognitive Function, Balance and Functional Lndependence in Children

The purpose of the study is to determine the impact of different levels of traumatic brain injury on cognitive function, functional independence and balance on children and relation of cognitive dysfunction, balance disturbance and functional independence

Study Overview

Status

Active, not recruiting

Conditions

Traumatic Brain Injury

Detailed Description

50 hundred children with traumatic brain injury from both sexes will participate in this study and fifty normal volunteer children for age matching group.

Materials:

For selection: The Glasgow Coma Scale
For evaluation: A. For Cognitive assessment: The Wechsler Intelligence Scale for Children- Fourth Edition (WISC-IV) B. Bruininks-Oseretsky Test of Motor Proficiency

C.Functional Independence Measure for Children:

Wee Functional Independence Measure (Wee FIM)

Study Type

Observational

Enrollment (Estimated)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Egypt
- - Cairo, Egypt, 02
    - Cairo University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Child

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

24 children with traumatic brain injury from both sexes will participate in this study and 24 normal volunteer children for age matching group.

Description

Inclusion Criteria:

Children diagnosed with mild to moderate traumatic brain injury.
Their chronological age will be ranged from 8 years to 12 years.
All subjects medically controlled immediately after discharge.

Exclusion Criteria:

children with other neurological impairments or epilepsy.
Visual or hearing impairment
Motor or behavioral disorders before trauma such as Developmental Coordination Disorder (DCD) or Attention Deficit Hyperactive Disorder (ADHD).
Receiving medical drugs that can cause confusion or make child less alert.
any chronic diseases as cardiac or lung disease.
musculoskeletal contracture or disease.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
Group A. 24 children with traumatic brain injury from both sexes will participate in this s traumatic brain injury
24 normal volunteer children for age matching group. They will be selected from Zagazig universit normal volunteer children for age matching group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
COGNITIVE FUNCTION Time Frame: 60:120 minutes	The Wechsler Intelligence Scale for Children- Fourth Edition (WISC-IV) assessment containing fifteen subtests	60:120 minutes
balance Time Frame: 15:25 minute	Bruininks-Oseretsky Test of Motor Proficiency is a commonly diagnostic instrument in the evaluation of the development of psychometrics . It is categorized into four composite motor domains each one containing two motor subtests	15:25 minute

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Investigators

Study Chair: manal S.Eid abd elwahab, professor of physical therapy, prof cairo university
Study Director: Alaa F hassan, lecturer, Lecturer
Study Director: mustafa A EL Zohiery, lecturer, lecturer cairo university

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Andelic, N., Løvstad, M., Norup, A., Ponsford, J., & Røe, C. (2019). Editorial: Impact of Traumatic Brain Injuries on Participation in Daily Life and Work: Recent Research and Future Directions. Front Neurol, 10, 1153. https://doi.org/10.3389/fneur.2019.01153 Barman, A., Chatterjee, A., & Bhide, R. (2016). Cognitive Impairment and Rehabilitation Strategies After Traumatic Brain Injury. Indian J Psychol Med, 38(3), 172-181. https://doi.org/10.4103/0253-7176.183086 Bidzan-Bluma, I., & Lipowska, M. (2018). Physical Activity and Cognitive Functioning of Children: A Systematic Review. Int J Environ Res Public Health, 15(4). https://doi.org/10.3390/ijerph15040800 Bland, D. C., Zampieri, C., & Damiano, D. L. (2011). Effectiveness of physical therapy for improving gait and balance in individuals with traumatic brain injury: a systematic review. Brain injury, 25(7-8), 664-679. Bronstein, A. M. (2016). Multisensory integration in balance control. Handb Clin Neurol, 137, 57-66. https://doi.org/10.1016/b978-0-444-63437-5.00004-2 Bruininks, P., & Malle, B. F. (2005). Distinguishing hope from optimism and related affective states. Motivation and emotion, 29, 324-352. Capizzi, A., Woo, J., & Verduzco-Gutierrez, M. (2020). Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Med Clin North Am, 104(2), 213-238. https://doi.org/10.1016/j.mcna.2019.11.001 Chen, M., Dutt, A. S., & Nair, R. (2022). Systematic review of reviews on Activities of Daily Living measures for children with developmental disabilities. Heliyon, 8(6), e09698. https://doi.org/10.1016/j.heliyon.2022.e09698 Dewan, M. C., Rattani, A., Gupta, S., Baticulon, R. E., Hung, Y. C., Punchak, M., Agrawal, A., Adeleye, A. O., Shrime, M. G., Rubiano, A. M., Rosenfeld, J. V., & Park, K. B. (2018). Estimating the global incidence of traumatic brain injury. J Neurosurg, 130(4), 1080-1097. https://doi.org/10.3171/2017.10.Jns17352 Eriksen, B. A., & Eriksen, C. W. (1974). Effects of

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 14, 2025

Primary Completion (Actual)

February 22, 2026

Study Completion (Estimated)

July 1, 2026

Study Registration Dates

First Submitted

May 18, 2026

First Submitted That Met QC Criteria

May 23, 2026

First Posted (Actual)

May 28, 2026

Study Record Updates

Last Update Posted (Actual)