End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

June 5, 2026 updated by: Anna Bailey, Office of the Medical Director for EMS in Oklahoma City and Tulsa
The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2 (positive/negative) is a better predictor of patient survival to discharge. The secondary aim of this project is to identify significant predictors of neurologically intact patient survival as indicated by a cerebral performance category (CPC) score of 1-2.

Study Overview

Status

Active, not recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

3500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73135
        • Office of the Medical Director of EMS for Metropolitan Oklahoma City and Tulsa

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

This is a retrospective cohort study. All patients encountered by emergency medical services in Oklahoma City and Tulsa experiencing an out-of-hospital cardiac arrest from Jan 1, 2024, to July 1, 2025, will be evaluated against the inclusion and exclusion criteria.

Description

Inclusion Criteria

  • EHR's resulting from 9-1-1 response
  • Adult patients (aged 18+ at time of cardiac event)
  • experiencing out-of-hospital cardiac arrest (OHCA)
  • transported by an agency under OMD oversight
  • must have at least 2 EtCO2 values captured during care Exclusion Criteria
  • EHR's resulting from inter-facility scheduled or unscheduled medical transfers
  • pediatric patients (those aged <18 at time of incident) or unknown age
  • ROSC obtained prior to arrival of EMS
  • insufficient vital sign data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
stable ETCO2
low variation in measured end-tidal CO2 during cpr; low/high threshold yet to be determined
unstable/trending ETCO2
variability in end-tidal CO2 during CPR, with or without measurable trend

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Survival to Hospital Discharge
Time Frame: 90 days
lack of terminiation of CPR during prehospital or in hospital care
90 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Neurologically Intact Patient Survival
Time Frame: 90 days
Based on Gasgow-Pittsburgh Cerebral Performance Category (CPC) score which ranges from 1 (best) to 5 (worst). Neurologically intact is defined as a score of 1-2 among survivors
90 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Office of the Medical Director for EMS in Oklahoma City and Tulsa

Collaborators

Medtronic

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2024

Primary Completion (Actual)

July 1, 2025

Study Completion (Estimated)

September 30, 2026

Study Registration Dates

First Submitted

June 2, 2026

First Submitted That Met QC Criteria

June 2, 2026

First Posted (Actual)

June 8, 2026

Study Record Updates

Last Update Posted (Actual)

June 9, 2026

Last Update Submitted That Met QC Criteria

June 5, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ERP#14222 (Other Grant/Funding Number: Medtronic)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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