Out of Hospital Cardiac Arrest: Trial Assessing the Survival Impact of Phone Advice (CONTAC)

Out of Hospital Cardiac Arrest: Cluster Randomized Trial Assessing the Survival Impact of Phone Advice Delivered by Medical Call Center

Medical call center have no phone advice protocol within out of hospital cardiac arrest in France. The purpose of the present study is to compare a group of patients with protocol phone advice delivered by the dispatchers ("CONTARM" group) versus usual phone advice ( "CONTHAB" group). Comparison will be performed on survival to seven days. The hypothesis is that CONTARM group has an higher survival at seven days. A second goal is to measure the survival to 15 and 30 days. The trial is randomized, controlled and will include 2600 patients. The patients will be enrolled in 19 hospitals in France.

Study Overview

• Status: Completed
• Conditions: Out of Hospital Cardiac Arrest
• Intervention / Treatment: Other: Protocol phone advice; Other: Usual phone advice

• Study Type: Interventional
• Enrollment (Actual): 729
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Angers, France
    • Chu Angers
  • Besançon, France
    • CHU Besançon
  • Bordeaux, France
    • CHU Bordeaux
  • Châlon sur Saône, France
    • CH Chalon sur Saone
  • Colmar, France
    • CH Colmar
  • Dijon, France
    • Chu Dijon
  • Lons Le Saunier, France
    • Ch Lons Le Saunier
  • Lyon, France
    • CHU Lyon
  • Metz, France
    • CHU Metz
  • Montauban, France
    • CH Montauban
  • Mulhouse, France
    • CH Mulhouse
  • Nancy, France
    • CHU Nancy
  • Nantes, France
    • Chu Nantes
  • Nîmes, France
    • CHU Nimes
  • Orléans, France
    • CH Orléans
  • Poitiers, France
    • CHU Poitiers
  • Reims, France
    • CHU Reims
  • Strasbourg, France
    • CHU Strasbourg
  • Troyes, France
    • Ch Troyes

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• > 18 years old
• initial call to 15
• out of hospital cardiac arrest
• patient proximity to witness

Exclusion Criteria:

• first aid professionals on site
• rigor mortis
• location not allowing resuscitation
• inability to realize actions or misunderstanding
• no flow > 5 minutes

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: CONTARM; Protocol phone advice	Other: Protocol phone advice; Protocol phone advice
Other: CONTHAB; Usual phone advice	Other: Usual phone advice; Usual phone advice

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
7 days survival	7 days survival	7 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
15 and 30 days survival	15 and 30 days survival	15 and 30 days
Assessment of compliance of phone advice	Listening of phone bands to measure compliance of phone advice protocol : good frequency of chest compression. Binary variable (Yes or Not); good depth of chest compression. Binary variable (Yes or Not); good patient positioning. Binary variable (Yes or No).	7 days
30 days neurological status	Cerebral performance categories scale is counting with medical file	30 days

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Besançon
• Collaborators: Hospices Civils de Lyon; University Hospital, Strasbourg, France; University Hospital, Angers; Centre Hospitalier Universitaire Dijon; Central Hospital, Nancy, France; University Hospital, Bordeaux; Poitiers University Hospital; Centre Hospitalier Universitaire de Nīmes; Nantes University Hospital; Reims University hospital; Groupe Hospitalier de la Region de Mulhouse et Sud Alsace; Centre Hospitalier de Montauban; Centre Hospitalier de Troyes; University Hospital, Metz; Centre Hospitalier de Lons Le Saunier; Centre Hospitalier de Chalon sur Saône; UNIVERSITY HOSPITAL, ORLEANS; Centre Hospitalier de Colmar

Publications and helpful links

General Publications

• Nolan JP, Soar J, Zideman DA, Biarent D, Bossaert LL, Deakin C, Koster RW, Wyllie J, Bottiger B; ERC Guidelines Writing Group. European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary. Resuscitation. 2010 Oct;81(10):1219-76. doi: 10.1016/j.resuscitation.2010.08.021. No abstract available.
• Berg RA, Hemphill R, Abella BS, Aufderheide TP, Cave DM, Hazinski MF, Lerner EB, Rea TD, Sayre MR, Swor RA. Part 5: adult basic life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010 Nov 2;122(18 Suppl 3):S685-705. doi: 10.1161/CIRCULATIONAHA.110.970939. Erratum In: Circulation. 2011 Oct 11;124(15):e402.
• Koster RW, Baubin MA, Bossaert LL, Caballero A, Cassan P, Castren M, Granja C, Handley AJ, Monsieurs KG, Perkins GD, Raffay V, Sandroni C. European Resuscitation Council Guidelines for Resuscitation 2010 Section 2. Adult basic life support and use of automated external defibrillators. Resuscitation. 2010 Oct;81(10):1277-92. doi: 10.1016/j.resuscitation.2010.08.009. No abstract available.
• Desmettre T, Jenvrin J, Freysz M, Nace L, Puyraveau M, Berthier F, Dreyfus P, Philippe MH, Labourey JM, Capellier G. Drug prescription at the medical call center. Ann. Fr. Med. Urgence (2013) 3:14-19.
• Sigaux A, Jonquet S, Puyraveau M, Bretillot L, Labourey JM, Capellier G, Desmettre T. Evaluation of phone advice delivered by a medical call center in case of cardiac arrest. Ann. Fr. Med. Urgence (2014) 4:11-17.

Study record dates

Study Major Dates

• Study Start (Actual): October 12, 2016
• Primary Completion (Actual): October 12, 2021
• Study Completion (Actual): October 19, 2021

Study Registration Dates

• First Submitted: July 26, 2016
• First Submitted That Met QC Criteria: October 13, 2016
• First Posted (Estimated): October 17, 2016

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: January 15, 2025
• Last Verified: January 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Heart Diseases; Heart Arrest; Out-of-Hospital Cardiac Arrest
• Other Study ID Numbers: CONTAC R/2015/50