Sellar Masses: Clinical and Imaging Features With Correlation to Histopathology and Surgical Approach

Sellar, Supra-sellar and Para-sellar Region Masses: Clinical Spectrum and Imaging Features With Correlation to Histopathology and Surgical Approach: A Prospective Descriptive Study.

The goal of this observational study is to learn about the clinical spectrum of sellar masses, aiming to understand the correlation between the imaging features and the future surgical approach and histopathology results.

The main question it aims to answer is:

Does being both LMIC and conflict country change the global data!? Participants were included during a period of 3 years in a governmental hospital TMGH.

Study Overview

• Status: Completed
• Conditions: Sellar Masses
• Intervention / Treatment: Procedure: Craniectomy

• Study Type: Observational
• Enrollment (Actual): 49

Contacts and Locations

Study Locations

• Yemen
  • Sanaa, Yemen, 975
    • Thawrh General Modern Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

included all Patients presenting with sellar region masses from December 2022 to December 2025, at Neurosurgical department at TMGH

Description

Inclusion Criteria:

• Radiologically confirmed sellar, suprasellar, or parasellar mass.
• Surgical candidacy
• Histopathological confirmation
• Age ≥ 11 year

Exclusion Criteria:

• Incomplete diagnostics
• Recurrent disease
• Primary metastatic disease.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Patients with confirmed sellar masses; Patients withe age of 11 to 65, who was diagnosed with sellar mass using MRI, and get treated surgically	Procedure: Craniectomy; Bicoronal vs. Pterional approach vs endoscopic

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation between pre-operative radiological features and definitive histopathological diagnosis.	To evaluate the diagnostic accuracy of pre-operative magnetic resonance imaging (MRI) by determining the percentage of cases where pre-operative radiological features match the definitive post-operative histopathological classification (e.g., pituitary adenoma, craniopharyngioma, meningioma).	3 years

Collaborators and Investigators

• Sponsor: Arab Board of Neurosurgery
• Investigators: Study Director: Adnan Al- Awdi, Neurosurgical consultant, Arabic Board of Neurosurgery MD

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2022
• Primary Completion (Actual): December 1, 2025
• Study Completion (Actual): December 1, 2025

Study Registration Dates

• First Submitted: May 28, 2026
• First Submitted That Met QC Criteria: June 5, 2026
• First Posted (Actual): June 8, 2026

Study Record Updates

• Last Update Posted (Actual): June 8, 2026
• Last Update Submitted That Met QC Criteria: June 5, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Keywords: Histopathology; Sellar mass; Imaging Features
• Additional Relevant MeSH Terms: Surgical Procedures, Operative; Neurosurgical Procedures; Craniotomy
• Other Study ID Numbers: TMGH-2026-Ethics-30

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: Individual participant data will not be shared publicly to protect patient confidentiality and privacy. The informed consent obtained from the participants covers the publication of aggregated study findings within the manuscript and tables only, and does not include explicit permission for the public disclosure of raw, de-identified individual clinical or radiological datasets."

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No