Metabolic and Clinical Effects of Hyperchloremia During HoLEP Surgery.

June 13, 2026 updated by: Betül Güven, Ankara City Hospital Bilkent

Evaluation of the Metabolic and Clinical Effects of Intraoperative Hyperchloremia in Holmium Laser Enucleation of Prostate (HoLEP) Surgery.

This study aims to evaluate the changes between preoperative and postoperative serum chloride levels in patients undergoing HoLEP surgery and to investigate the metabolic and clinical effects of this change. The study is observational, and no additional interventions will be performed.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Although isotonic irrigation fluids used in HoLEP surgery reduce the risk of hyponatremia associated with TUR syndrome, high-volume fluid absorption may lead to hyperchloremia and subsequent metabolic acidosis. This prospective, observational, single-center study, conducted at Ankara Bilkent City Hospital, aims to identify early markers of this condition to optimize perioperative management.

Study Type

Observational

Enrollment (Estimated)

45

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Patients scheduled for elective HoLEP surgery.

Description

Inclusion Criteria:

  • Patients scheduled for elective HoLEP surgery.
  • Patients providing written informed consent

Exclusion Criteria:

  • Preoperative metabolic acidosis.
  • Advanced renal failure.
  • Emergency surgery.
  • Missing data.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients undergoing elective HoLEP surgery.
Procedure: HoLEP surgery
All parameters are part of routine clinical practice; no additional examinations are required

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in serum chloride level
Time Frame: Perioperative
Perioperative

Secondary Outcome Measures

Outcome Measure
Time Frame
irrigation volume
Time Frame: Perioperative
Perioperative
Arter blood gas
Time Frame: Perioperative
Perioperative

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ankara City Hospital Bilkent

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

July 4, 2026

Primary Completion (Estimated)

August 30, 2026

Study Completion (Estimated)

September 30, 2026

Study Registration Dates

First Submitted

June 5, 2026

First Submitted That Met QC Criteria

June 13, 2026

First Posted (Actual)

June 18, 2026

Study Record Updates

Last Update Posted (Actual)

June 18, 2026

Last Update Submitted That Met QC Criteria

June 13, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • TABED1-26-2505

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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