Evaluation of OMEGA-3 Effect in Alveolar Socket Preservation in Aesthetic Zone

Evaluation of OMEGA-3 Effect in Alveolar Socket Preservation in Aesthetic Zone: A Case Series

To evaluate the effect of Omega-3 in preserving bone after extraction

Study Overview

• Status: Completed
• Conditions: Socket Preservation; Omega-3 Fatty Acids; Esthetic Zone
• Intervention / Treatment: Dietary supplement: Omega 3 Fish Oil supplements

Detailed Description

The evaluation of the effect of omega-3 on the bone of the socket with changes in the dimensions like vertical and horizontal bone changes 3months after extraction .

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt
    • Faculty of Dentistry

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Patients with non-restorable remaining roots.
2. Patients free of systemic conditions that might affect the surgical procedure or the quantity or quality of bone (uncontrolled hypertension, uncontrolled diabetes).

Exclusion Criteria:

1. Patients below 18 years old
2. Patients with hypersensitivity to omega-3, drug formulations or allergic to seafood.
3. Pregnant or lactating females
4. Patients undergoing chemotherapy or radiotherapy
5. Smokers

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Atraumatic extraction for single rooted teeth and placement of omega-3 in the socket; Atraumatic extraction for single rooted teeth in anterior zone and omega-3 polyunsaturated fatty acid placed with collagen sponge inside the extraction socket for socket preservation and implant placement	Dietary supplement: Omega 3 Fish Oil supplements; omega-3 fatty acid supplement; Other Names: Omega-3

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Post-operative pain	Visual Analogue Scale score "VAS score" From 0-10 scores score 0 is no pain which is the best 1-4 is mild pain 5 is moderate pain from 5 -10 pain is getting worse and 10 is the worst	immediately after extraction and the second day after extraction

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Radiographic bone changes "horizontal bone changes " using Cone beam CBCT	Performing one CBCT before extraction and one new CBCT after 3 months of extraction and omega-3 placement then comparing both CBCTs by J image computer program to get the difference in vertical bone measurements in millimeter	before extraction and 3months after omega 3 placement
Radiographic bone changes " Vertical bone fill" using CBCT	Performing one CBCT before extraction and one new CBCT after 3 months of extraction and omega-3 placement then comparing both CBCTs by J image computer program to get the difference in vertical bone measurements in millimeter	before and after 3 months of extraction and omega-3 placement
Radiographic bone changes "Bone density" using CBCT	Performing one CBCT before extraction and one new CBCT after 3 months of extraction and omega-3 placement then comparing both CBCTs by J image computer program to get the radiographic bone changes in millimeter and Hounsfield units	3 months after extraction and placement of omega-3
Histological examination	using Hematoxylin and Eosin staining to measure the area of newly formed bone "Percentage"	after 3months of extraction during implant placement bone is taken using trephine bur
Healing Index "HI" by Landry et al using scores	Using Landry et al wound healing index to measure soft tissue reaction changes. Each category is scored from 1 to 5, with 1 indicating very poor healing and 5 indicating excellent healing. The HI is a useful tool for assessing the quality of wound healing and guiding postoperative interventions.	after 3months of omega 3 placement

Collaborators and Investigators

• Sponsor: Cairo University

Publications and helpful links

Helpful Links

• Polyunsaturated fatty acids and its effect on inflammation

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2025
• Primary Completion (Actual): October 24, 2025
• Study Completion (Actual): October 25, 2025

Study Registration Dates

• First Submitted: May 27, 2026
• First Submitted That Met QC Criteria: June 18, 2026
• First Posted (Actual): June 24, 2026

Study Record Updates

• Last Update Posted (Actual): June 24, 2026
• Last Update Submitted That Met QC Criteria: June 18, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Keywords: Omega-3; Implant; Socket preservation; Atraumatic extraction; Esthetic zone; Extraction socket
• Additional Relevant MeSH Terms: Fatty Acids; Lipids; Fatty Acids, Unsaturated; Oils; Dietary Fats; Fats; Fatty Acids, Omega-3; Dietary Fats, Unsaturated; Fish Oils; Docosahexaenoic Acids
• Other Study ID Numbers: 30122024

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No