- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02534389
Fish Oil Supplement in Rectal Cancer
February 8, 2017 updated by: AC Camargo Cancer Center
Fish Oil Supplement Combined With Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer
Neoadjuvant treatment with radiotherapy (RDT) and chemotherapy (CT) are the treatment of choice for rectal adenocarcinomas in stages II and III.
This results currently in pathologic complete response in 10% to 30% of cases.
The immune and inflammatory response is altered in these individuals and is directly related to response to therapy.
Both the disease and the treatment of colorectal cancer have an impact on quality of life and nutritional status.
In studies with cells and animal models the incorporation of fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) - derived from fish oil - has been shown to interfere in the process of inflammation, cell signaling and gene transcription enhancing the response to treatment.
Are reported ability to restore the apoptosis of tumor cells, sensitization of tumor cells to chemotherapy, production of less pro-inflammatory cytokines and the preservation of normal energy and protein metabolism.
The aim of this study is to verify if the daily consumption of 2.4 g EPA + DHA for adults in neoadjuvant therapy can promote changes on inflammatory and immunological markers of host response to tumor and if this response is altered by nutritional status.
It is expected that supplementation can reflect in control of inflammatory and immune response in favor of tumor cell death contributes to pathological complete response and that it happens with preservation of nutritional status.
Subjects will be randomized as to supplementation.
All will be assessed in four moments during neoadjuvant therapy and immediate postoperative.
Results will be presented by comparing the intervention group and control group at each moment.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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São Paulo, Brazil, 01509 - 010
- AC Camargo Câncer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Candidate to neoadjuvant therapy according AC Camargo Cancer Center protocol;
- Accept consume fish oil capsules and participate in clinical, pathological and nutritional assessments by signing the consent form.
Exclusion Criteria:
- Be allergic to fish and fish products,
- It has previously undergone treatment for colorectal cancer or in presence of other concomitant cancer treatment.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: fish oil group
4 soft gel with omega-3 fish oil
|
2,4g of EPA + DHA
|
No Intervention: control group
without intervention
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Check effects of daily consumption of 2.4 g of EPA + DHA for adults with rectal adenocarcinoma in neoadjuvant chemoradiation treatment on Glasgow Prognostic Score (GPS).
Time Frame: 18 months
|
Combination of C-reactive protein and albumin, the Glasgow Prognostic Score (GPS), had independent prognostic value in patients with cancer.
The GPS is the most extensively validated of the systemic inflammation-based prognostic scores and may be used in the routine clinical assessment of patients with cancer.
|
18 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Check effects of daily consumption of 2.4 g of EPA + DHA for adults with rectal adenocarcinoma in neoadjuvant chemoradiation treatment on body weight and body composition with regard to skeletal muscle mass, and adipose tissue.
Time Frame: 18 months
|
Measures: weight (kg) / Muscle mass (Kg) / adipose mass (Kg).
Involuntary weight loss is common among patients with advanced cancer, contributing to poor treatment response, functional decline, and decreased survival.
Nutritional intervention with fish oil may prevent deterioration of body composition.
|
18 months
|
Check for effects of daily consumption of 2.4 g of EPA + DHA for adults with rectal adenocarcinoma in neoadjuvant chemoradiation treatment on muscle function.
Time Frame: 18 months
|
Measure: hand grip strength (kg).
Muscle function, assessed by hand grip strength, has been reported to be closely related to body composition and even more to muscle mass loss (sarcopenia).
|
18 months
|
Check for effects of daily consumption of 2.4 g of EPA + DHA for adults with rectal adenocarcinoma in neoadjuvant chemoradiation treatment on quality of life (QOL).
Time Frame: 24 months
|
Measured: specific oncologic questionnaire (EORTC QLQ-C30).
The amount of symptoms distressed experienced by an individual has been related to QoL in a number of people with cancer.
QoL is increasingly being used as a primary outcome measure in studies to evaluate the effectiveness of treatment.
|
24 months
|
Check for effects of daily consumption of 2.4 g of EPA + DHA for adults with rectal adenocarcinoma in neoadjuvant chemoradiation treatment on inflammatory cytokines (IL-6, IL-1, TNF-alpha).
Time Frame: 18 months
|
Measures: IL-6/ IL-1 / TNF-alpha.
The cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha) and interleukin-1 beta (IL-1beta) are critical mediators of the inflammatory response.
Evidence has linked elevated levels of inflammatory cytokines with both loss of weight and therapeutical response.
|
18 months
|
Check for effects of daily consumption of 2.4 g of EPA + DHA for adults with rectal adenocarcinoma in neoadjuvant chemoradiation treatment on pathological response.
Time Frame: 24 months
|
measure: pathological response grade.
Pathological complete response after neoadjuvant chemoradiation and radical surgery in patients with locally advanced rectal cancer predicts better outcomes.
|
24 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Samuel Aguiar Jr., PhD, AC Camargo Câncer Center
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2015
Primary Completion (Actual)
July 1, 2016
Study Completion (Actual)
February 1, 2017
Study Registration Dates
First Submitted
August 17, 2015
First Submitted That Met QC Criteria
August 25, 2015
First Posted (Estimate)
August 27, 2015
Study Record Updates
Last Update Posted (Estimate)
February 9, 2017
Last Update Submitted That Met QC Criteria
February 8, 2017
Last Verified
February 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1818/2013
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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