Performance of Amino Acid PET in Brain Metastases (DYNAMET)

June 24, 2026 updated by: Antoine VERGER, Central Hospital, Nancy, France

Static and Dynamic Performance of Amino Acid PET for Differentiating Radiation Necrosis From Tumor Progression in Irradiated Brain Metastases (DYNAMET)

Differentiating radiation necrosis from tumor progression in patients with brain metastases has a major therapeutic and prognostic implications

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Differentiating radiation necrosis from tumor progression in patients with brain metastases treated with radiotherapy is a major challenge in post-treatment management, as the therapeutic and prognostic implications differ substantially depending on whether the lesion represents radiation necrosis (surveillance, anti-angiogenic therapy) or tumor progression (re-initiation of local or systemic treatment).

In addition to brain MRI, amino acid PET imaging, including both static and dynamic acquisitions, is a key diagnostic tool for this purpose.

However, the added value of dynamic acquisitions remains uncertain, and the available evidence is limited to small patient series.

Study Type

Observational

Enrollment (Estimated)

80

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

All patients referred for amino acid PET imaging in the Nuclear Medicine Department of Nancy University Hospital for the differential diagnosis between radiation necrosis and brain tumor progression between November 1, 2018, and April 30, 2026.

Description

Inclusion Criteria:

  • Patients who received a PET amino acid for differentiating radiation necrosis from progression of irradiated brain metastases,

Exclusion Criteria:

  • Patients who refused the using of their data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To compare the diagnostic performance amino acid PET imaging
Time Frame: Day 1
Uptake of tumor
Day 1

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To evaluate the potential impact of immunotherapy administered before or during PET imaging
Time Frame: 2 weeks
MRI results
2 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

August 5, 2026

Primary Completion (Estimated)

September 3, 2026

Study Completion (Estimated)

November 3, 2026

Study Registration Dates

First Submitted

June 24, 2026

First Submitted That Met QC Criteria

June 24, 2026

First Posted (Actual)

June 30, 2026

Study Record Updates

Last Update Posted (Actual)

June 30, 2026

Last Update Submitted That Met QC Criteria

June 24, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • 2026PI251

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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