Investigating the Effectiveness of Oral Care With Green Tea and White Tea in Preventing Ventilator-Associated Pneumonia in Mechanically Ventilated Patients (TEA-VAP)

June 30, 2026 updated by: Guleren Yartas Dumanli, Recep Tayyip Erdogan University

Comparison of Chlorhexidine, Green Tea, and White Tea Oral Care for the Prevention of Ventilator- Associated Pneumonia in Mechanically Ventilated Patients

This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV)

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This prospective controlled interventional study included 63 mechanically ventilated adult intensive care unit patients. Participants were assigned to one of three oral care groups receiving chlorhexidine (CHX), green tea, or white tea according to the study protocol. Oral health was assessed using the Bedside Oral Examination (BOE) guide on days 1, 3, and 7. The primary objective was to compare the incidence of ventilator-associated pneumonia (VAP) among the study groups. Secondary outcomes included changes in oral health status and functional oral assessment during follow-up.

Study Type

Interventional

Enrollment (Actual)

63

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
    • Merkez
      • Rize, Merkez, Turkey (Türkiye), 53020
        • Recep Tayyip Erdogan University Research and Training Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Aged over 18 years
  2. With no known allergies
  3. Receiving invasive mechanical ventilator support
  4. With a negative endotracheal aspirate culture on the day of ICU admission
  5. Within the first 24 hours of mechanical ventilator support
  6. Patients whose relatives agreed to participate in the study

Exclusion Criteria:

  1. Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission,
  2. Patients undergoing radiotherapy or chemotherapy,
  3. Patients with contraindications for oral care,
  4. Patients with a platelet count below 30,000/mm³,
  5. Patients who cannot be positioned appropriately,
  6. Patients with agitation severe enough to prevent the procedure from being performed

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: chlorhexidine group
Participants received oral care using chlorhexidine solution according to the study protocol.
Procedure: Clorhexidine group
oral care using clorhexidine solution, green tea and white tea
Other Names:
  • clorhexidine
Experimental: green tea group
Participants received oral care using green tea according to the study protocol.
Procedure: Green Tea group
Participants received oral care using green tea according to the study protocol.
Other Names:
  • green tea
Experimental: white tea group
Participants received oral care using white tea according to the study protocol.
Procedure: white tea group
Participants received oral care using white tea according to the study protocol.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ventilator associated pneumonia devolopment
Time Frame: 7 days
Comparison of the incidence of ventilator-associated pneumonia among the chlorhexidine, green tea, and white tea oral care groups.
7 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Recep Tayyip Erdogan University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2024

Primary Completion (Actual)

December 31, 2025

Study Completion (Actual)

April 1, 2026

Study Registration Dates

First Submitted

June 30, 2026

First Submitted That Met QC Criteria

June 30, 2026

First Posted (Actual)

July 7, 2026

Study Record Updates

Last Update Posted (Actual)

July 7, 2026

Last Update Submitted That Met QC Criteria

June 30, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RTEU-2024-TEAVAP
  • 2024-KAEK-25 (Other Identifier: Recep Tayyip Erdogan University Ethics Committee)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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