The Genomic and Well-Being Impacts of an Extraverted Behavior Intervention

July 1, 2026 updated by: Ramona Martinez, University of California, Riverside
8-week randomized intervention (with 3-month follow-up) that examines the impact of increased sociable behavior on emotional well-being and immune health profile

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

119

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Riverside, California, United States, 92521
        • Department of Psychology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age 18 or older

Exclusion Criteria:

  • Younger than 18 years of age

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Sociable (extraverted) behavior
Participants asked to act more outgoing and talkative
Behavioral: Sociable (extraverted) behavior
Participants asked to act more sociable (extraverted) 3 days a week for 6 weeks on days of their choosing with the goal of promoting social connection. 8-week study includes week 0 pre-test measures and week 1 baseline of sociable behavior "as usual."
Sham Comparator: Daily routine list
Participants asked to list their daily routines without changing behavior
Behavioral: Sociable (extraverted) behavior
Participants asked to act more sociable (extraverted) 3 days a week for 6 weeks on days of their choosing with the goal of promoting social connection. 8-week study includes week 0 pre-test measures and week 1 baseline of sociable behavior "as usual."

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Self-reported loneliness (survey)
Time Frame: From enrollment to end of study period at 8 weeks
Responses to loneliness sub-scale of Comprehensive Inventory of Thriving
From enrollment to end of study period at 8 weeks
Self-reported positive and negative affect (survey)
Time Frame: From enrollment to end of study period at 8 weeks
Responses to 12-item survey, Affect-Adjective Scale
From enrollment to end of study period at 8 weeks
Immune gene profile
Time Frame: From enrollment to end of study period at 8 weeks
Changes to immune gene profile assayed in dried blood spots
From enrollment to end of study period at 8 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Self-reported psychological well-being (survey)
Time Frame: From enrollment to end of study period at 8 weeks
Responses to the Mental Health Continuum-Short Form
From enrollment to end of study period at 8 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of California, Riverside

Collaborators

National Institute on Aging (NIA)

Investigators

  • Principal Investigator: Elissa Eppel, PhD, UC San Francisco

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 8, 2024

Primary Completion (Actual)

December 5, 2024

Study Completion (Actual)

December 22, 2024

Study Registration Dates

First Submitted

July 1, 2026

First Submitted That Met QC Criteria

July 1, 2026

First Posted (Actual)

July 8, 2026

Study Record Updates

Last Update Posted (Actual)

July 8, 2026

Last Update Submitted That Met QC Criteria

July 1, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 15154
  • U24AG072699 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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