Photofunctionalization and Hyaluronic Acid for Posterior Maxillary Implants (PHOTOHA)

July 8, 2026 updated by: Mansoura University

Enhancing Implant Success in the Posterior Maxilla: The Impact of Photofunctionalization and Hyaluronic Acid

This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

The study compares conventional implants, UV-photofunctionalized implants, and UV-photofunctionalized implants with hyaluronic acid application in the posterior maxilla. Implant stability and peri-implant tissue changes will be evaluated clinically and radiographically during follow-up.

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Al Mansurah, Egypt
        • Faculty of Dentistry Mansoura University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients with missed single tooth or multiple teeth in posterior maxilla.
  • Patients Free from any para-functional habits.
  • Patient with Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
  • Patient with good oral hygiene.
  • Patients Willing to participate in the study's follow-up intervals.

Exclusion Criteria:

  • Patients with any local or systemic disease that absolute contraindicate implant placement or surgery.
  • Pregnancy.
  • Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site.
  • Patients on drugs that could affect bone healing process such as bisphosphonate.
  • Heavy Smokers for more than 10 cigarettes a day.
  • Uncooperative patients.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Study Group 1
20 non-UV activated implants were inserted into the prepared osteotomy site in posterior maxilla.
Procedure: Delayed dental implant placement without photofunctionalization.
Delayed dental implants placed without photofunctionalization or hyaluronic acid in the posterior maxilla.
Experimental: Study group 2
20 UV activated implants were inserted into the prepared osteotomy site in posterior maxilla.
Procedure: Delayed dental Implant photofunctionalization before placement
Delayed dental implants photofunctionalized with UV light before placement in the posterior maxilla.
Experimental: Study Group 3
20 UV activated implants with Hyaluronic acid applied topically on implants surface and into the prepared osteotomy sites in posterior maxilla.
Procedure: Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.
Delayed dental implants photofunctionalized with UV light and treated with hyaluronic acid before placement in the posterior maxilla.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Hard Tissue (peri-implant bone)
Time Frame: - Immediately postoperative - 3 months after implant placement - 9 months after implant placement.
Marginal bone loss will be assessed using CBCT measured in mm.
- Immediately postoperative - 3 months after implant placement - 9 months after implant placement.
Implant Stability
Time Frame: -immediately after implant placement -2 weeks postoperatively -4 weeks postoperatively - 3 months postoperatively - 9 months postoperatively
Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).
-immediately after implant placement -2 weeks postoperatively -4 weeks postoperatively - 3 months postoperatively - 9 months postoperatively

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Soft Tissue
Time Frame: -After 3 months postoperatively. -After 9 months postoperatively.
The peri-implant mucosa will be evaluated for signs of inflammation using the Modified Sulcus Bleeding Index (mSBI).
-After 3 months postoperatively. -After 9 months postoperatively.
Peri-implant probing depth
Time Frame: After 3 months postoperatively. -After 9 months postoperatively.
Probing depth will be assessed using a calibrated periodontal probe and measured in mm.
After 3 months postoperatively. -After 9 months postoperatively.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mansoura University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 1, 2025

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

August 1, 2026

Study Registration Dates

First Submitted

July 8, 2026

First Submitted That Met QC Criteria

July 8, 2026

First Posted (Actual)

July 14, 2026

Study Record Updates

Last Update Posted (Actual)

July 14, 2026

Last Update Submitted That Met QC Criteria

July 8, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • R.26.02.107

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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