True Muscle Transplantation Surgery Versus Augmented Semi Hang Back Recession in Large Angle Exotropia: Evaluation of Efficacy and Lateral Gaze Incomitance

August 20, 2026 updated by: Hassnaa Mohamed Abdelhameed Ahmed
This a randomized clinical trial comparing True muscle transplantation surgery versus Augmented Semi hang back recession for treatment of large angle exotropia

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

large angle exotropia is a challenging to treat surgically .40 patients will be randomized into 2 groups and followed for 6 months to assess alignment and success rate

Study Type

Interventional

Enrollment (Estimated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Minya Governorate
      • Minya, Minya Governorate, Egypt, 61111
        • Recruiting
        • Minya University Hospital - Ophthalmology Department

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Patients with large angle exotropia more than 50 prism diopters.
  2. No previous squint surgery.

Exclusion Criteria:

  1. Patients with severe ocular surface diseases as ocular cicatricial pemphigoid and severe dry eye.
  2. Severe systemic illness that prevents general anesthesia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: True Muscle Transplantation Surgery
Patients in this group will undergo True Muscle Transplantation Surgery For treatment of large angle exotropia
Procedure: True Muscle Transplantation Surgery
true Muscle Transplantation surgery for treatment of large angle Exotropia
Experimental: Augmented Semi hang back Recession
Patients in this group will undergo Augmented Semi hang back Recession for treatment of large angle exotropia
Procedure: Augmented Semi hang back Recession
Augmented Semi hang back Recession for treatment of large angle Exotropia

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Surgical success rate at 6 months
Time Frame: 6 months post-surgery
Proportion of patients with ocular alignment within 10 prism diopters of orthotropia measured by prism and alternate cover test
6 months post-surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hassnaa Mohamed Abdelhameed Ahmed

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 1, 2026

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

January 1, 2027

Study Registration Dates

First Submitted

August 20, 2026

First Submitted That Met QC Criteria

August 20, 2026

First Posted (Actual)

August 25, 2026

Study Record Updates

Last Update Posted (Actual)

August 25, 2026

Last Update Submitted That Met QC Criteria

August 20, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MiniaU-Oph- 2026-EXOT-01

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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