Clinical Trials on ALK-activated Tumors

Total 439593 results

Seattle Children's Hospital

Active, not recruiting

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Glioma | Ependymoma | Medulloblastoma | Pineoblastoma | Central Nervous System Tumor, Pediatric | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma

United States
Seattle Children's Hospital

Active, not recruiting

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

Glioma | Ependymoma | Medulloblastoma | Pineoblastoma | Central Nervous System Tumor, Pediatric | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma

United States
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

An Open-label Phase 3 Study of Lutetium (177Lu) Oxodotreotide Injection in Subjects With Advanced Gastrointestinal Pancreatic Neuroendocrine Tumors.

Advanced Gastroenteropancreatic Neuroendocrine Tumor

China
Eli Lilly and Company

Completed

A Study of LY2334737 in Participants With Cancer That is Advanced and/or Has Spread

Solid Tumor | Malignant Solid Tumor | Metastatic Tumor

Germany, United States, France
University of Iowa
Novartis

Not yet recruiting

177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry (LUMOD-ID)

Neuroendocrine Tumors | Neuroendocrine Tumor Grade 2 | Neuroendocrine Tumor Grade 1

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma

Brain Tumor | Central Nervous System Tumor

United States, Canada, Puerto Rico, Australia, Netherlands, New Zealand, Switzerland
Royal Marsden NHS Foundation Trust
Merck Sharp & Dohme LLC; Institute of Cancer Research, United Kingdom; National...

Completed

Pembrolizumab and Palliative Radiotherapy in Lung (PEAR)

Thoracic Tumours

United Kingdom
Peter Anderson

Completed

Phase 2 Study of ONC201 in Neuroendocrine Tumors

Metastatic Neuroendocrine Tumor | Recurrent Neuroendocrine Tumor

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors

Brain and Central Nervous System Tumors | Extragonadal Germ Cell Tumor | Pediatric Germ Cell Tumor

United States
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

Gallium (68Ga) Edotreotide PET/CT for Imaging Patients With Gastrointestinal Pancreatic Neuroendocrine Tumors

Advanced Gastroenteropancreatic Neuroendocrine Tumor
Burzynski Research Institute

Terminated

Antineoplaston Therapy in Treating Patients With Metastatic, Recurrent, or Refractory Primitive Neuroectodermal Tumors

Primitive Neuroectodermal Tumor

United States
Weill Medical College of Cornell University

Recruiting

Tissue Collection for Drug Screening and Bioanalysis

Central Nervous System Tumor | Pediatric Central Nervous System Tumor

United States
Molecular Insight Pharmaceuticals, Inc.

Withdrawn

Study to Evaluate the Efficacy and Safety of 90Y-SMT487 in Subjects With Symptomatic Malignant Carcinoid Tumors

Malignant Carcinoid Tumor
Second Affiliated Hospital, School of Medicine,...

Recruiting

A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis

Autoimmune Encephalitis | Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

China
UCB Biopharma SRL

Terminated

A Study to Test the Efficacy, Safety, and Pharmacokinetics of Rozanolixizumab in Adult Study Participants With Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

United States, Australia, Belgium, France, Germany, Italy, Netherlands, Spain, United Kingdom
Giselle Sholler
K C Pharmaceuticals Inc.; USWM, LLC

Available

An Intermediate Expanded Use Trial of DFMO

Embryonal Tumor With Abundant Neuropil and True Rosettes | Medulloblastoma | Neuroblastoma | Medulloepithelioma | Ependymoblastoma | Typical Teratoid Rhabdoid Tumor

United States
Assistance Publique - Hôpitaux de Paris

Completed

Confrontation Phenotypes and Genotypes of Epithelial Odontogenic Tumors of the Jaws (TEIOS)

Epithelial Odontogenic Tumours

France
Ipsen

Terminated

A Retrospective Data Analysis of Therapy With PRRT Combined With Lanreotide Autogel® for Neuroendocrine Tumours (PRELUDE)

Neuroendocrine Tumours

United Kingdom, France, Germany, Australia, Italy
Societe Internationale d'Oncologie Pediatrique

Completed

Surgery Plus Radiation Therapy With or Without Chemotherapy in Treating Children With Primitive Neuroectodermal Tumors of the CNS

Brain and Central Nervous System Tumors

United Kingdom
Francesco De Cobelli

Completed

CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms

Pancreatic Neuroendocrine Tumor

Italy
University Medical Center Groningen

Completed

Repeat CT for Evaluation of Inter- and Intrafraction Changes During Curative Thoracic Radiotherapy (REACT)

Thoracic Tumor

Netherlands
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal Tumors

Brain and Central Nervous System Tumors | Neuroblastoma

United States
Universitätsklinikum Hamburg-Eppendorf

Completed

Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma

Ependymoma | Medulloblastoma, Childhood | Cerebral Primitive Neuroectodermal Tumor

Germany
Grupo Espanol de Tumores Neuroendocrinos

Active, not recruiting

Platinum-doublet Chemotherapy and Nivolumab for the Treatment of Subjects With Neuroendocrine Neoplasms (NENs) of the Gastroenteropancreatic (GEP) Tract or of Unknown (UK) Origin.

Neuroendocrine Tumors | Neuroendocrine Neoplasm | Gastroenteropancreatic Neuroendocrine Tumor

Spain
Arcispedale Santa Maria Nuova-IRCCS

Completed

68-Ga-labeled Octreotide Analogues PET in Duodenal-pancreatic Neuroendocrine Tumours

Neuroendocrine Tumours

Austria, Italy
TaiRx, Inc.

Active, not recruiting

Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors

Neuroendocrine Tumors | Gastro-enteropancreatic Neuroendocrine Tumor | Neuroendocrine Carcinoma | Pancreatic Neuroendocrine Tumor | Lung Neuroendocrine Neoplasm

Taiwan
CHU de Reims

Completed

Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors

Small-intestine Neuroendocrine Tumors (Carcinoid Tumors)

France
Massachusetts General Hospital
National Cancer Institute (NCI)

Completed

In-Room PET in Proton Radiation Therapy

Brain Tumor | Head and Neck Tumor | Skull Base Tumor

United States
Roswell Park Cancer Institute
National Comprehensive Cancer Network

Completed

Nintedanib in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors

Carcinoid Tumor | Neuroendocrine Neoplasm | Metastatic Carcinoid Tumor

United States
Prisma Health-Midlands

Withdrawn

Early Intrapleural TPA Instillation Versus Late (ELEVATE)

Tissue Plasminogen Activator

United States
Burzynski Research Institute

Completed

Antineoplaston Therapy in Treating Children With Primitive Neuroectodermal Tumors (PNET)

Childhood CNS Primitive Neuroectodermal Tumor

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

Medulloblastoma | Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor | Anaplastic Medulloblastoma | Supratentorial Embryonal Tumor, Not Otherwise Specified

United States, Canada, Australia, Puerto Rico
Children's Hospital of Fudan University

Recruiting

Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome

Activated PI3K-delta Syndrome | Immunodeficiency Primary

China
Ipsen

Completed

To Evaluate the Optimal Dose of 68Ga-OPS202 as a PET (Positron Emission Tomography) Imaging Agent in Subjects With Gastroenteropancreatic Neuroendocrine Tumour (GEP-NET)

Gastro-Enteropancreatic Neuroendocrine Tumor

United States, Austria, Denmark
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors

Testicular Germ Cell Tumor | Ovarian Cancer | Brain and Central Nervous System Tumors | Teratoma | Extragonadal Germ Cell Tumor

United States
Fudan University
Tongji Hospital; Qilu Hospital of Shandong University; Tianjin Medical University... and other collaborators

Not yet recruiting

Comparison of Kimura Versus Warshaw Technique for Laparoscopic Spleen-Preserving Distal Pancreatectomy

Pancreatic Neuroendocrine Tumor | Solid Pseudopapillary Tumor of the Pancreas | Pancreatic Tumor, Benign
Memorial Sloan Kettering Cancer Center
AstraZeneca

Recruiting

A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer

Solid Tumor | Metastatic Cancer | Metastatic Solid Tumor | Solid Tumor, Adult | Solid Carcinoma | Metastatic Tumor

United States
Centre Leon Berard
Transgene

Completed

Immunization Strategy With Intra-tumoral Injections of Pexa-Vec With Ipilimumab in Metastatic / Advanced Solid Tumors. (ISI-JX)

Advanced Tumor | Metastatic Tumor

France
Hutchmed

Active, not recruiting

Open-Label Surufatinib in European Patients With NET

Neuroendocrine Tumours | Neuroendocrine Tumour of the Lung | Small Intestinal NET

Spain, France, United States, United Kingdom, Norway, Germany, Italy
Centre Hospitalier Universitaire de Besancon

Completed

Preliminary Study of Microwave Tumoral Ablation Performances for the Treatment of Pulmonary, Renal and Bone Neoplasia. (TherMO)

Renal Tumor | Bone Tumor | Lung Tumor

France
Beijing Tiantan Hospital

Recruiting

Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China (GRIPP)

Glioma | Ependymoma | Medulloblastoma | Central Nervous System Tumor, Pediatric | Germ Cell Tumor | Brain Tumor, Pediatric

China
Sue O'Dorisio

Completed

Safety of 68Ga-DOTA-tyr3-Octreotide PET in Diagnosis of Solid Tumors (GA-68)

Neuroendocrine Tumors | Medulloblastoma | Neuroblastoma | Carcinoid Tumors

United States
Massachusetts General Hospital

Withdrawn

A Pilot Study Of Ga-68-DOTA-TOC Imaging In Participants With Small Bowel Carcinoid Tumors

Small Bowel Carcinoid Tumor

United States
University Medical Center Groningen

Completed

Web-based Tailored Information and Support for Patients With a Neuroendocrine Tumor (WIN)

Neuroendocrine Tumor

Netherlands
Thomas Hope

Completed

Yttrium-90 DOTA-TOC Intra-arterial (IA) Peptide Receptor Radionuclide Therapy (PRRT) for Neuroendocrine Tumor

Neuroendocrine Tumor

United States
Samsung Medical Center

Completed

Study of Pazopanib Monotherapy in Patients With Unresectable, Metastatic Neuroendocrine Tumor

Neuroendocrine Tumor

Korea, Republic of
Nuclear Medicine Consultants, Inc.

Unknown

Heart/Mediastinal Ratio Study for Potential Equivalence of Heart/Mediastinal Ratios at One and Two Hours to the Traditional Heart/Mediastinal Ratio Obtained at Four Hours

Neuroendocrine Tumor

United States
Dana-Farber Cancer Institute
Massachusetts General Hospital; Beth Israel Deaconess Medical Center; Brigham...

Completed

Thalidomide in Combination With Temodar in Patients With Neuroendocrine Tumors

Neuroendocrine Tumor

United States
Peking University Third Hospital

Recruiting

Accuracy of Coplanar Template Assistance for Abdominal Tumor Puncture

Abdominal Tumor

China
University Medical Center Groningen

Completed

Repeat CT Scans for Evaluation of Inter- and Intrafraction Motion and it's Effect on Radiotherapy Dose Distribution During Curative Radiotherapy for Pelvic Tumours (RACE)

Pelvic Tumor

Netherlands

Clinical Trials on ALK-activated Tumors

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in China

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations