Clinical Trials on Advanced Adult Hepatocellular Carcinoma

Total 4306 results

Daiichi Sankyo, Inc.

Terminated

An Open Study Assessing the Safety and Tolerability of U3-1784

Advanced Solid Tumors | Hepatocellular Cancer (HCC)

United Kingdom
Ascentawits Pharmaceuticals, Ltd

Recruiting

A Phase I/II Study of AST-3424 in Subjects With Advanced Solid Tumors

Hepatocellular Carcinoma | Advanced Solid Tumors

China
TORL Biotherapeutics, LLC
Translational Research in Oncology

Recruiting

A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

Hepatocellular Carcinoma | Advanced Solid Tumor

United States
Qilu Pharmaceutical Co., Ltd.

Recruiting

A Phase Ib/II Trial to Evaluate the Safety and Efficacy of QL1706 in Patients With Advanced Hepatocellular Carcinoma

Advanced Liver Cancer

China
Sumitomo Pharma Co., Ltd.

Completed

A Study of BBI503 in Advanced Solid Tumors, or BBI503/ Sorafenib in Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma | Advanced Solid Tumors

Japan
Chang Gung Memorial Hospital

Completed

Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence

Adult Hepatocellular Carcinoma | Recurrent Hepatocellular Carcinoma | Adverse Reaction to Drug | Vascular Endothelial Growth Factor Overexpression

Taiwan
Chugai Pharmaceutical

Completed

A Phase I Study of GC33 in Advanced or Metastatic Liver Cancer (Hepatocellular Carcinoma)

Advanced or Metastatic HCC

United States
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

Hepatocellular Carcinoma | Solid Tumor, Adult

China
Eureka Therapeutics Inc.

Recruiting

T-Cell Therapy (ECT204) in Adults With Advanced HCC (ARYA-3)

Hepatocellular Carcinoma | Liver Neoplasm | Metastatic Liver Cancer | Liver Cancer, Adult

United States
Center Eugene Marquis
Rennes University Hospital

Completed

188RE-SSS Lipiodol to Treat HepatoCellular Carcinomas (LIP-RE-I)

Hepatocellular Carcinomas

France
National Cancer Centre, Singapore
INTRA-IMMUSG PRIVATE LIMITED

Recruiting

Phase II Study of PRL3-ZUMAB in Advanced Solid Tumors

Hepatocellular Carcinoma | Gastric Cancer | Advanced Solid Tumor

Singapore
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Trametinib Combined With Everolimus and Lenvatinib for Recurrent/Refractory Advanced Solid Tumors

Hepatocellular Carcinoma | Solid Tumor, Adult

China
Assistance Publique - Hôpitaux de Paris

Completed

Multipolar Radiofrequency Ablation for Hepatocellular Carcinoma Using Extra Nodular Versus Intranodular Technique (ARMCENVIN)

Hepatocellular Carcinomas

France
Repare Therapeutics
Roche Pharma AG

Recruiting

Study of RP-3500 (Camonsertib) With Niraparib or Olaparib in Advanced Solid Tumors (ATTACC)

Advanced Solid Tumor, Adult

United States
CellAct Pharma GmbH
Mundipharma-EDO GmbH

Terminated

CAP7.1 for the Treatment of Advanced Stage, Therapy Refractory Lung and Biliary Tract Tumors (CAP7-1)

Advanced Endstage Solid Carcinomas in Adults

Germany
Istanbul Demiroglu Bilim University

Recruiting

Liver Transplantation in Patients With Incidental Hepatocellular-cholangiocarcinoma and Intrahepatic Cholangiocarcinoma: A Single-center Experience

Adult Combined Hepatocellular-Cholangiocarcinoma

Turkey
Polaris Group

Terminated

Ph 1-2 Study ADI-PEG 20 Plus FOLFOX in Subjects With Advanced GI Malignancies Focusing on Hepatocellular Carcinoma

Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Advanced Gastrointestinal (GI) Malignancies

United States, Taiwan, Korea, Republic of, United Kingdom, China, Italy
National Cancer Institute (NCI)

Completed

Tremelimumab With Chemoembolization or Ablation for Liver Cancer

Hepatocellular Carcinoma | Biliary Tract Neoplasms | Liver Cancer | Biliary Cancer | Heptocellular Cancer

United States
Edward Kim
Bristol-Myers Squibb; National Cancer Institute (NCI)

Terminated

BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver Cancer

Unresectable Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma... and other conditions

United States
Northwestern University
Bristol-Myers Squibb; National Cancer Institute (NCI)

Completed

Nivolumab and Yttrium Y 90 Glass Microspheres in Treating Patients With Advanced Liver Cancer

Stage IIIA Hepatocellular Carcinoma | Stage IIIB Hepatocellular Carcinoma | Stage IIIC Hepatocellular Carcinoma | Stage IVA Hepatocellular Carcinoma | Stage IVB Hepatocellular Carcinoma

United States
OHSU Knight Cancer Institute
Oregon Health and Science University; American Society of Clinical Oncology; Radiological... and other collaborators

Withdrawn

Y-90 Versus SBRT for Inoperable HCC

Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma AJCC v8 | Stage IB Hepatocellular Carcinoma AJCC v8 | Stage II Hepatocellular Carcinoma AJCC v8 | Stage... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Radioembolization for HCC Patients With Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)

Unresectable Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma...

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Yttrium Y 90 Glass Microspheres in Treating Patients With Unresectable Hepatocellular Carcinoma

Unresectable Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma...

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Viral Therapy in Treating Patient With Refractory Liver Cancer or Advanced Solid Tumors

Hepatocellular Carcinoma | Advanced Malignant Solid Neoplasm

United States
Robin Kate Kelley
Bristol-Myers Squibb; Bayer

Active, not recruiting

Sorafenib and Nivolumab in Treating Participants With Unresectable, Locally Advanced or Metastatic Liver Cancer

Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma AJCC v7 | Stage IIIC Hepatocellular Carcinoma AJCC v7 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular...

United States
Emory University
National Cancer Institute (NCI); Eisai Co., Ltd.

Recruiting

Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant

Unresectable Hepatocellular Carcinoma | Recurrent Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC... and other conditions

United States
Imugene Limited

Recruiting

A Study of CF33-hNIS (VAXINIA), an Oncolytic Virus, as Monotherapy or in Combination With Pembrolizumab in Adults With Metastatic or Advanced Solid Tumors (MAST)

Solid Tumor | Metastatic Cancer | Advanced Solid Tumor | Solid Tumor, Adult | Solid Carcinoma

United States, Australia
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Camrelizumab Utilization on Patients With Advanced Liver Cancer

Advanced Hepatocellular Carcinoma

China
AstraZeneca
Hospital Israelita Albert Einstein

Not yet recruiting

Brazilian Reality of Hepatocellular Carcinoma (BRA-HEP)

Hepatocellular Carcinoma | Hepatocellular Carcinoma by BCLC Stage | Hepatocellular Carcinoma Stage I | Hepatocellular Carcinoma Stage III | Hepatocellular Carcinoma Stage II

Brazil
Chinese University of Hong Kong

Active, not recruiting

EUS Guided Cyanoacrylate Injection vs Endoscopic Variceal Band Ligation for Prevention of Rebleeding in Patients With Hepatocellular Carcinoma and Esophageal Variceal Bleeding (EUSgluevsVBL)

EUS Guided Cyanoacrylate Injection | Endoscopic Variceal Band Ligation | Hepatocelular Carcinoma | Esophageal Variceal Bleeding

Hong Kong
Sirtex Medical
Bright Research Partners

Recruiting

Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma Patients (DOORwaY90)

Unresectable Hepatocellular Carcinoma | BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma | BCLC Stage A Hepatocellular Carcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Suspended

Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer

Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma AJCC v8 | Unresectable Fibrolamellar...

United States
M.D. Anderson Cancer Center

Recruiting

Atezolizumab and Bevacizumab Before Surgery for the Treatment of Resectable Liver Cancer

Stage IB Hepatocellular Carcinoma AJCC v8 | Stage II Hepatocellular Carcinoma AJCC v8 | Resectable Hepatocellular Carcinoma | Stage I Hepatocellular Carcinoma AJCC v8 | Stage IA Hepatocellular Carcinoma AJCC v8

United States
Coherus Biosciences, Inc.
Shanghai Junshi Bioscience Co., Ltd.; Medpace, Inc.

Active, not recruiting

Study to Evaluate Safety and PK of CHS-006 in Combination With Toripalimab in Patients With Advanced Solid Tumors

Hepatocellular Carcinoma | Non-Small Cell Lung Cancer | Advanced Solid Tumor

United States
Royal North Shore Hospital

Active, not recruiting

Liver Function Investigation With SPECT (LiverINSPECT)

Liver Cancer, Adult

Australia
Ohio State University Comprehensive Cancer Center
Varian Medical Systems

Completed

Stereotactic Body Radiation Therapy and Transarterial Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

Child-Pugh Class A | Stage IIIA Hepatocellular Carcinoma | Stage IIIB Hepatocellular Carcinoma | Stage IIIC Hepatocellular Carcinoma | Stage IVA Hepatocellular Carcinoma | Stage IVB Hepatocellular Carcinoma | Child-Pugh Class B

United States
University Hospital Inselspital, Berne

Completed

Accuracy Assessment for Computer-assisted Surgical Interventions of the Liver (CALS)

Adult Liver Cancer

Switzerland
Stanford University
National Cancer Institute (NCI)

Recruiting

Development of 3DMPUS as a Decision Support Tool for Patients With Liver Tumors Undergoing Therapy (3DMPUS)

Liver Cancer, Adult

United States
Centre Hospitalier Universitaire de Saint Etienne

Terminated

Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver Resection. (BLOC-TAP)

Liver Cancer, Adult

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab With or Without Elbasvir/Grazoprevir and Ribavirin in Treating Patients With Advanced Refractory Liver Cancer

Stage IIIB Hepatocellular Carcinoma AJCC v7 | Stage IIIC Hepatocellular Carcinoma AJCC v7 | BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma | Hepatitis C Infection | Stage IV Hepatocellular Carcinoma AJCC v7 | Stage III Hepatocellular Carcinoma AJCC v7 | Stage IIIA Hepatocellular... and other conditions

United States
Ningbo Cancer Hospital

Unknown

PD-1 Antibody Expressing CAR T Cells for Mesothelin Positive Advanced Malignancies

Advanced Cancer | Solid Tumor, Adult

China
National Cancer Institute (NCI)

Not yet recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Metastatic Melanoma | Locally Advanced Melanoma | Metastatic Alveolar Soft Part Sarcoma | Metastatic Non Small Cell Lung Cancer | Metastatic Hepatocellular Carcinoma | Locally Advanced Hepatocellular Carcinoma | Metastatic Small Cell Lung Cancer | Locally Advanced Non Small Cell Lung Cancer | Locally... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

IRX-2, Cyclophosphamide, and Nivolumab in Treating Patients With Recurrent or Metastatic and Refractory Liver Cancer

Recurrent Hepatocellular Carcinoma | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Refractory Liver Carcinoma

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Recruiting

Regorafenib and Durvalumab for the Treatment of High-Risk Liver Cancer

Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IB Hepatocellular Carcinoma AJCC v8 | Stage II Hepatocellular Carcinoma AJCC v8

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Stereotactic Body Proton Radiotherapy for the Treatment of Liver Cancer

Recurrent Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage II Hepatocellular Carcinoma AJCC v8 | Stage I Hepatocellular Carcinoma AJCC v8

United States
Kaohsiung Medical University Chung-Ho Memorial...
Kaohsiung Medical University

Recruiting

Evaluation the Palliative Effects of Colchicine on Primary Hepatic Malignant Tumors Unable to Receive Curative Treatment

Cholangiocarcinoma, Intrahepatic | Hepatocellular Carcinoma Stage IIIB | Cholangiocarcinoma; With Hepatocellular Carcinoma | Hepatocellular Carcinoma Stage IV

Taiwan
AstraZeneca

Terminated

A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.

Gastric Cancer | Advanced Solid Malignancies | Solid Tumour | Child-Pugh A to B7 Advanced Hepatocellular Carcinoma | EGFR and/or ROS Mutant NSCLC | Lung Metastasis Carcinoma

Korea, Republic of
Stanford University

Completed

B-mode Ultrasound Imaging in Detecting Early Liver Cancer

Fibrosis | Cirrhosis | Stage I Hepatocellular Carcinoma | Stage II Hepatocellular Carcinoma | Early Hepatocellular Carcinoma

United States
NKGen Biotech, Inc.

Active, not recruiting

Safety of SNK01 in Subjects With Pathologically Confirmed Metastatic and/or Unresectable Cancer Refractory to Conventional Therapy

Metastatic Cancer | Advanced Solid Tumor | Advanced Cancer | Solid Tumor, Adult | Refractory Cancer | Recurrent Cancer | Unresectable Carcinoma

United States
BeiGene

Completed

Preliminary Antitumor Activity, Safety and Tolerability of Tislelizumab in Combination With Lenvatinib for Hepatocellular Carcinoma

Hepatocellular Carcinoma | Unresectable Hepatocellular Carcinoma | Metastatic Hepatocellular Carcinoma

China

Clinical Trials on Advanced Adult Hepatocellular Carcinoma

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