Clinical Trials on Advanced Gastrointestinal Cancer

Total 68381 results

Eisai Inc.

Completed

A Phase II Study of the Safety and Efficacy of E7820 Plus Cetuximab in Colorectal Cancer, Preceded by a Run-in Study in Advanced Solid Tumors

Advanced Colorectal Cancer

United States, Canada
Novartis Pharmaceuticals

Terminated

Glivec® Plus m-FOLFOX Avastin® in Advanced Colorectal Cancer

Advanced Colorectal Cancer

Australia
University Hospital, Ghent

Completed

High Dose Simplified Folfiri in Advanced Colorectal Cancer: a Multicentre Phase II Study

Advanced Colorectal Cancer

Belgium
Teon Therapeutics, Inc.
Merck Sharp & Dohme LLC

Terminated

TT-816 as Monotherapy or in Combination With a PD-1 Inhibitor in Patients With Advanced Cancers (SEABEAM) (MK3475-E88)

Cancer | Advanced Solid Tumor | Advanced Cancer | Oncology

United States
British Columbia Cancer Agency

Completed

Chemoradiation for Locally Advanced and Low Rectal Cancers: Avastin-Capecitabine-Oxaliplatin-Radiation REctal Cancer Trial

Advanced Colorectal Cancer

Canada
Xijing Hospital

Not yet recruiting

Efficacy and Safety of Neoadjuvant Sintilimab Plus FLOT Versus Sintilimab Plus SOX Phase II Clinical Trial for Patients With Locally Advanced Gastric Cancer

Sintilimab | Neoadjuvant Chemotherapy | Locally Advanced Gastric Cancer
M.D. Anderson Cancer Center

Not yet recruiting

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

Advanced Colorectal Cancer

United States
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Recruiting

Injection of SHR-A1811 Versus Physician Choiced Treatment in Patients With Advanced Colorectal Cancer Who Had Failed to Respond to Oxaliplatin, 5-fu, and Irinotecan

Advanced Colorectal Cancer

China
Zhejiang Cancer Hospital

Not yet recruiting

Cetuximab in Combination With Dabrafenib and Tislelizumab in BRAF Mutated Treatment of Advanced Colorectal Cancer

Advanced Colorectal Cancer

China
Sun Yat-sen University

Recruiting

A Prospective Cohort Study of Advanced Colorectal Cancer Treated With Oxaliplatin and Irinotecan.

Advanced Colorectal Cancer

China
Jiangsu Cancer Institute & Hospital

Recruiting

A Study of Bevacizumab Plus XELOX/XELIRI for First-line Treatment in Unresectable Advanced Colorectal Cancer

Advanced Colorectal Cancer

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

Study of SHR-1210 in Combination With Chemotherapy in Advanced Esophageal Cancer

Advanced Esophageal Cancer

China
Cancer Trials Ireland

Completed

Identification of New Patient Stratification Tools in MSS RAS mt mCRC (COLOSSUS)

Advanced Colorectal Cancer

Spain, Ireland, Germany
Memorial Sloan Kettering Cancer Center
AstraZeneca; MedImmune LLC

Completed

Evaluate the Efficacy of MEDI4736 in Immunological Subsets of Advanced Colorectal Cancer

Advanced Colorectal Cancer

United States
PharmaMar

Completed

Clinical Trial of PM60184 in Advanced Colorectal Cancer After Standard Treatment

Advanced Colorectal Cancer

United States, Canada, Spain
The First Affiliated Hospital of Guangdong Pharmaceutical...
Guangzhou Anjie Biomedical Technology Co., Ltd.

Unknown

CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer

Advanced Esophageal Cancer

China
Henan Cancer Hospital
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Apatinib Treatment for Advanced Esophagus Cancer

Advanced Esophagus Cancer

China
Royal Marsden NHS Foundation Trust

Terminated

Methotrexate in Metastatic Colorectal Cancer With MSH2 Deficiency (MESH)

Advanced Colorectal Cancer

United Kingdom
Novartis Pharmaceuticals

Completed

Safety and Efficacy of RAD001 (Everolimus) Monotherapy Plus Best Supportive Care in Patients With Advanced Gastric Cancer (AGC) (GRANITE-1)

Advanced Gastric Cancer

China, United States, Belgium, France, Taiwan, United Kingdom, Canada, Spain, Italy, Australia, Russian Federation, Thailand, Korea, Republic of, Israel, Germany, Peru, Argentina, Japan, Hong Kong, New Zealand, Mexico, Netherlands
li xiong

Suspended

Safety and Efficiency of Photodynamic Therapy for Rectal Cancer (PDT-R-01)

Advanced Rectal Cancer

China
Shanghai Jiao Tong University School of Medicine

Unknown

Oxaliplatin, Capecitabine and Endostar as First Line Treatment for Patients With Advanced Colorectal Cancer (OXCE)

Advanced Colorectal Cancer

China
Peking University
Biotech Pharmaceutical Co., Ltd.

Unknown

Study of Nimotuzumab to Treat Colorectal Cancer

Advanced Colorectal Cancer

China
Beijing Friendship Hospital
Changhai Hospital; Peking Union Medical College Hospital; Peking University Cancer...

Not yet recruiting

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

Locally Advanced Rectal Cancer

China
Sun Yat-sen University
Akeso; Haplox Biotechnology Co., Ltd.

Recruiting

Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Fudan University

Not yet recruiting

Short-course Radiotherapy Combined With Chemotherapy and Pd-1 Inhibitor for Locally Advanced Colon Cancer(TORCH-C) (TORCH-C)

Locally Advanced Colon Cancer
Peking Union Medical College Hospital

Not yet recruiting

TIME in Immunotherapy Combined With nCRT for Rectal Cancer (TIMENT-R)

Locally Advanced Rectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

mFOLFOX6 Combined With Dalpiciclib in Patients With Metastatic Colorectal Cancer (FIND)

Advanced/Metastatic Colorectal Cancer

China
Beijing Friendship Hospital
Peking University First Hospital; Peking University People's Hospital; Peking... and other collaborators

Recruiting

Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer (POLAR-STAR)

Locally Advanced Rectal Cancer

China
Second Affiliated Hospital, School of Medicine,...

Recruiting

SALIRI Based Regimen as First-line Treatment for Advanced Metastatic Colorectal Cancer

Advanced Metastatic Colorectal Cancer

China
Zhejiang Cancer Hospital

Recruiting

Dendrobium Huoshanense Suppository in Rectal Cancer

Locally Advanced Rectal Cancer

China
Universidad de León

Recruiting

Analysis of the Effectiveness of Neoadjuvant Chemotherapy in the Treatment of Colon Cancer Locally Advanced (ELECLA) (ELECLA)

Locally Advanced Colon Cancer

Spain
Fundación para el Fomento de la Investigación Sanitaria...
Hospital General Universitario Elche

Recruiting

Organ Preservation in Locally Advanced Rectal Cancer (PRONAR)

LOCALLY ADVANCED RECTAL CANCER

Spain
Fujian Medical University

Completed

Neoadjuvant Treatment Based on Gastric Cancer Molecular Subtyping.

Neoadjuvant Therapy | Advanced Gastric Cancer | Multi-omics Analysis

China
Gruppo Oncologico del Nord-Ovest

Active, not recruiting

Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29 (ShorTrip)

Locally Advanced Rectal Cancer

Italy
University Medical Center Goettingen
German Research Foundation

Active, not recruiting

Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanced Primary Resectable Rectal Cancer Stages UICC-II-IV, With a 5-Fluorouracil-based Standard Radiochemotherapy Followed by Total Mesorectal Excision. (TransValid-A)

Locally Advanced Rectal Cancer

Germany
Hospital Pedro Hispano

Completed

Evaluation of Inflammatory Markers in LARC Patients

Locally Advanced Rectal Cancer
Cancer Trials Ireland

Terminated

Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer (TRI-LARC)

Locally Advanced Rectal Cancer

Ireland
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer

Locally Advanced Rectal Cancer

United States, Spain
First Affiliated Hospital of Zhejiang University

Unknown

Neoadjuvant mFOLFOXIRI Chemotherapy Alone for Extramural Vascular Invasion Positive Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Sun Ying-Shi

Completed

Predicting Pathological Complete Response of Rectal Cancer With Magnetic Resonance(MR) Radiomics

Locally Advanced Rectal Cancer

China
Fudan University

Unknown

Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Fujian Cancer Hospital

Unknown

Comparison of Short Term Outcomes Between Totally Laparoscopic and Laparoscopy-Assisted Distal Gastrectomy With Billroth-II Reconstruction and D2 Lymphadenectomy for Locally Advanced Gastric Cancer

Locally Advanced Gastric Cancer | Total Laparoscopic Distal Gastrectomy
Michelle Mossa
University of Liverpool

Completed

The Effect of Cancer Therapies and Exercise on Mitochondrial Energetics and Fitness

Locally Advanced Rectal Cancer

United Kingdom
Institute of Oncology Ljubljana

Unknown

Preoperative Radiotherapy With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer: CRAB Phase II Study (CRAB)

Locally Advanced Rectal Cancer

Slovenia
BiOneCure Therapeutics Inc.

Recruiting

A Study in Patients With Advanced Cancers

Cancer | Advanced Solid Tumor | Advanced Cancer | Oncology

United States
Sun Yat-sen University

Active, not recruiting

PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer

DMMR Colorectal Cancer | MSI-H Colorectal Cancer | Locally Advanced Colorectal Cancer

China
Zhejiang University

Recruiting

IMC001 for Clinical Research on Advanced Digestive System Malignancies

Advanced Colorectal Cancer | Advanced Hepatocellular Carcinoma | Advanced Gastric Cancer | Advanced Pancreatic Cancer

China
Wuhan Union Hospital, China
Renmin Hospital of Wuhan University

Recruiting

Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study

Locally Advanced Rectal Cancer

China
Beijing Friendship Hospital
Peking Union Medical College Hospital

Not yet recruiting

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

Locally Advanced Rectal Cancer

China
JIN JING

Not yet recruiting

Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13） (AK104-IIT-13)

Locally Advanced Rectal Cancer

Clinical Trials on Advanced Gastrointestinal Cancer

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