Clinical Trials on Advanced Stage IIIB

Total 13661 results

E-DA Hospital

Completed

Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery

Head and Neck Neoplasms | Complication,Postoperative | Fasting | Hyperglycemia Stress | Stress-related Problem | Muscle Wasting | Catabolic State | Feeding, Time Restricted

Taiwan
Tampere University

Completed

Live Enterovirus Vaccine and Type 1 Diabetes

Type 1 Diabetes | Prediabetic State | Enterovirus Infection
Institut Guttmann
The University of Queensland

Unknown

Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia

Brain Injuries, Traumatic | Alteration of Cognitive Function | Confusional State | Sensory Motor System Disorder

Spain
AstraZeneca

Completed

Phase 3 /Seroquel SR Acute Mania Monotherapy - US

Mania | Manic Disorder | Manic State | Affective Psychosis, Bipolar | Manic-Depressive Psychosis | Psychoses, Manic-Depressive

United States
Peking University People's Hospital
Peking Union Medical College Hospital; Peking University Third Hospital; Tongji... and other collaborators

Recruiting

Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer

Endometrial Neoplasms | Carcinoma, Endometrioid | Fertility Preservation | Endometrial Neoplasm Malignant Stage I | Endometrial Neoplasm Malignant

China
Centre hospitalier de l'Université de Montréal...
The Kidney Foundation of Canada

Recruiting

Non-invasive Assessment to Predict Tolerance to Fluid Removal on Intermittent Kidney Replacement Therapy (TECHNO-HDF)

Acute Kidney Injury | Fluid Overload | Chronic Kidney Failure | Intradialytic Hypotension | Chronic Kidney Disease Stage 5 on Dialysis

Canada
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

Recurrent Breast Carcinoma | Metastatic Triple-Negative Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Stage IV Breast Cancer AJCC v6 and v7 | Metastatic Breast Carcinoma | Metastatic BRCA Hereditary Breast Carcinoma

United States, Puerto Rico
Queen Mary University of London
AstraZeneca

Completed

AZD1656 in Transplantation With Diabetes tO PromoTe Immune TOleraNce (ADOPTION)

Diabetes Mellitus, Type 2 | End Stage Renal Disease | Type 2 Diabetes | Renal Transplant | Kidney Transplant; Complications

United Kingdom
National Institute of Diabetes and Digestive and...
Massachusetts General Hospital; University of Pennsylvania; Yale University; New... and other collaborators

Completed

HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis (HOPE)

Chronic Pain | End Stage Renal Disease | Opioid Dependence

United States
University of Wisconsin, Madison
Prostate Cancer Foundation; Madison Vaccines, Inc

Completed

Vaccine Therapy and Pembrolizumab in Treating Patients With Hormone-Resistant, Metastatic Prostate Cancer

Metastatic Prostate Carcinoma | Prostate Adenocarcinoma | Metastatic Malignant Neoplasm in the Bone | Metastatic Malignant Neoplasm in the Soft Tissues | Recurrent Prostate Carcinoma | Stage IV Prostate Cancer | Hormone-Resistant Prostate Cancer

United States
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University...

Completed

Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis

End Stage Renal Disease | Renal Osteodystrophy

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Personalized NK Cell Therapy in CBT

Recurrent Hodgkin Lymphoma | Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Myelodysplastic Syndrome... and other conditions

United States
Indiana University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk

Depression | Insulin Resistance | PreDiabetes | Type 2 Diabetes | Depressive Symptoms | Major Depressive Disorder | Dysthymic Disorder

United States
University of Minnesota
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes

Stress Disorder | Alcohol Use Disorder | Anxiety Disorder/Anxiety State | Hypothalamic Pituitary Adrenal | Drinking to Cope

United States
Universidade da Coruña
Universidade do Porto; Center on Information and Communication Technologies

Completed

Use of Wearable Devices to Assess the Impact of Stress in Workers' Life Quality (SQoF-WEAR)

Quality of Life | Sleep Disorder | Burnout, Professional | Anxiety State | Stress Disorder

Spain
Tobira Therapeutics, Inc.

Completed

ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD

Type 2 Diabetes Mellitus | Prediabetic State | Non-alcoholic Fatty Liver Disease

United States, Puerto Rico
University of Modena and Reggio Emilia

Unknown

Evaluation of the Effect of Cataract Surgery on Cognitive Function in Very Elderly Patients

Dementia | Cataract | Cataract Senile | Mild Cognitive Impairment | Post-Op Complication | Delirium in Old Age | Delirium Confusional State | Cataract in Old Age

Italy
Sichuan Enray Pharmaceutical Sciences Company

Recruiting

Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in the Treatment of Advanced Solid Tumor (CNSI-Fe(II))

Cervical Cancer | Breast Cancer | Colorectal Cancer | Ovarian Cancer | Lung Cancer | Advanced Solid Tumor | Pancreas Cancer | Thyroid Cancer | Vulva Cancer

China
AP Biosciences Inc.

Not yet recruiting

A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients With Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected Malignancies (APT-CUBE)

Esophageal Squamous Cell Carcinoma (ESCC) | Locally Advanced or Metastatic Solid Tumors | Non Small Cell Lung Cancer (NSCLC) | Head and Neck Squamous Cell Carcinoma (HNSCC)
National Cancer Institute (NCI)

Recruiting

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Metastatic Renal Cell Carcinoma | Metastatic Melanoma | Advanced Locoregional Melanoma | Clear Cell Histology

United States
Zimmer Biomet

Recruiting

Clinical Outcomes Study of the Nexel Total Elbow

Post-traumatic Arthritis | Degenerative Arthritis | Elbow Joint Destruction | Post-traumatic Lesions | Ankylosed Joints | Advanced Rheumatoid Arthritis | Joint Instability or Loss of Motion | Acute Comminuted Articular Fracture of Elbow Joint Surfaces | Bone Loss Contributing to Elbow Instability | Bilateral...

United States, Australia, Finland, France, Germany, Italy, Netherlands, United Kingdom
NKGen Biotech, Inc.
Affimed GmbH

Terminated

Safety, Tolerability, and Anti-Tumor Activity of AFM24 in Combination With SNK01 in Subjects With Advanced/Metastatic EGFR-Expressing Cancers

Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Squamous Cell Carcinoma of Head and Neck | Advanced Solid Tumor | Metastatic Tumor | Refractory Tumor

United States
Mainline Biosciences, Inc.

Withdrawn

A Phase 1 Study to Evaluate Paclitaxel Conjugated CXC Receptor 4 Antagonist (MB1707) in Patients With Advanced Cancer

Breast Cancer | Pancreatic Neoplasms | Non Small Cell Lung Cancer | Advanced Solid Tumor | Ovary Cancer
Sumitomo Pharma America, Inc.

Completed

First-in-human Study of Oral TP-0903 (a Novel Inhibitor of AXL Kinase) in Patients With Advanced Solid Tumors

Advanced Solid Tumors | Recurrent Ovarian Carcinoma | Colorectal Carcinoma | EGFR Positive Non-small Cell Lung Cancer | BRAF-Mutated Melanoma

United States
Rain Oncology Inc

Withdrawn

Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss

Melanoma | Renal Cell Carcinoma | Gastric Cancer | NSCLC | Mesothelioma | Advanced Solid Tumor | Pancreas Adenocarcinoma | Urothelial Carcinoma Bladder | HNSCC | CDKN2A
Haihe Biopharma Co., Ltd.

Terminated

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors

Melanoma | Erdheim-Chester Disease | Non-Small-Cell Lung Cancer | Advanced Tumors | Other RAS/RAF/MEK/ERK Mutated Tumors

United States, China
Galina Velikova
The Leeds Teaching Hospitals NHS Trust; European Organisation for Research...

Completed

Long Term Implications of Rare Brain Tumours'

Quality of Life | Cognitive Impairment | Health-related Quality of Life | Long-term Effects of Cancer Treatment | WHO Grade II Oligodendroglial Tumor | WHO Grade III Oligodendroglial Tumor

Netherlands, United Kingdom
John Mitchell

Completed

Sleep and Quality of Life in Patients With Glycogen Storage Disease on Standard Versus Modified Uncooked Cornstarch

Glycogen Storage Disease Type III | Glycogen Storage Disease Type IA | Glycogen Storage Disease Type IB | Glycogen Storage Disease Type 0

Canada
Czech Lymphoma Study Group
Hoffmann-La Roche; Ministry of Health, Czech Republic

Completed

R-MegaCHOP-ESHAP-BEAM in Patients With High-Risk Aggressive B-Cell Lymphomas (R-MCEB)

Diffuse Large B-Cell Lymphoma. | Primary Mediastinal B-Cell Lymphoma | Follicular Lymphoma Grade III

Czech Republic
CAS Lamvac (Guangzhou) Biomedical Technology Co...
The Third Affiliated Hospital of Southern Medical University

Not yet recruiting

Plasmodium Immunotherapy for Advanced Ovarian Cancer

Advanced Ovarian Cancer

China
Bradley A. McGregor, MD
Bristol-Myers Squibb; Exelixis

Recruiting

Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC

Renal Cell Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | Unclassified Renal Cell Carcinoma | Collecting Duct Renal Cell Carcinoma | Translocation Renal Cell Carcinoma | Unresectable Advanced Renal Cell Carcinoma | Metastatic Ncc Renal Cell Carcinoma

United States
University of Bordeaux

Completed

Delay to Diagnosis in Digestive Cancerology by the General Practitioner Related to Covid-19 Pandemic Confinement

Advanced Cancer | Pandemic, COVID-19 | Diagnosis | Neoplasms, Colorectal | Neoplasms Pancreatic | General Practitioner | Neoplasm, Liver

France
Kyverna Therapeutics

Recruiting

A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Refractory Lupus Nephritis

Lupus Nephritis | Lupus Nephritis - World Health Organization (WHO) Class III | Lupus Nephritis - WHO Class IV

United States
Vitaflo International, Ltd

Completed

Evaluation of TYR Sphere

Alkaptonuria | Tyrosinemias | Tyrosinemia, Type I | Tyrosinemia, Type II | Tyrosinemia, Type III

United Kingdom
National Taiwan University Hospital
Sanofi

Completed

Eliglustat on Gaucher Disease Type IIIB

Gaucher Disease, Type III

Taiwan
Taiho Oncology, Inc.

Recruiting

Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors

Pancreatic Cancer | Esophageal Adenocarcinoma | Esophageal Squamous Cell Cancer | Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer | Siewert Type 1 GEJ Cancer

United States, Spain, Germany, France
NiKang Therapeutics, Inc.
Pfizer

Recruiting

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

Neoplasms | Kidney Cancer | Kidney Neoplasms | Carcinoma, Renal Cell | Urologic Neoplasms | Urogenital Neoplasms | Neoplasms by Site | Kidney Diseases | Urologic Diseases | Adenocarcinoma | Carcinoma | Neoplasms, Glandular and Epithelial | Clear Cell Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | Recurrent... and other conditions

United States
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Shandong Cancer Hospital and Institute

Recruiting

IMM2520, a PD-L1 and CD47 Bispecific Antibody in Patients With Advanced Solid Tumors

Breast Cancer | Small Cell Lung Cancer | Colorectal Cancer | Advanced Solid Tumor | Non-small Cell Lung Cancer | Squamous Cell Cancer of Head and Neck

China
Dana-Farber Cancer Institute
NH TherAguix SAS

Recruiting

Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

Non-small Cell Lung Cancer | Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Cancer | Ductal Adenocarcinoma of the Pancreas

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

A Study of Nivolumab In Combination With Cabozantinib in Patients With Non-Clear Cell Renal Cell Carcinoma

Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | Unclassified Renal Cell Carcinoma | Advanced or Metastatic Non-clear Cell Renal Cell Carcinoma | Fumarate Hydratase Deficient Renal Cell Carcinoma | Succinate Dehydrogenase Deficient Renal Cell Carcinoma | Collecting Duct Renal...

United States
Gradalis, Inc.

Temporarily not available

Expanded Access of Vigil in Solid Tumors

Cervical Cancer | Ovarian Cancer | Solid Tumor | Ewing Sarcoma | Uterine Cancer | Ewing's Tumor Metastatic | Ewing's Sarcoma Metastatic | Advanced Gynecological Cancers

United States
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

Glioblastoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Advanced Solid Tumors | Triple Negative Breast Cancer | Biliary Tract Cancers

United States, Argentina, Australia, Canada, Chile, Colombia, France, Germany, Israel, Italy, Korea, Republic of, Russian Federation, Spain, Switzerland, Taiwan, Thailand, United Kingdom
Cairo University
Misr International University

Completed

Comparison of Weekly Versus Every Three Weeks of Carboplatin Plus Paclitaxel in Patients With Advanced Epithelial Ovarian Cancer

Advanced Epithelial Ovarian Cancer

Egypt
zr Pharma & GmbH
Foundation Medicine

Completed

A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cancer | Advanced Solid Tumor With Evidence of Germline or Somatic BRCA

United States, Israel, Spain, Canada, United Kingdom
Threshold Pharmaceuticals

Completed

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | High-risk Myelodysplastic Syndrome | Advanced Myelofibrosis

United States
Hospital District of Helsinki and Uusimaa
Oulu University Hospital; University of Helsinki

Recruiting

Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery (AAMS2)

Coronary Artery Disease | Ischemic Heart Disease | Heart Failure, Systolic | Heart Failure NYHA Class II | Heart Failure NYHA Class III | Ischemic Cardiomyopathy | Heart Failure NYHA Class IV

Finland
University of Leipzig

Active, not recruiting

Native T1 CMR Imaging for Diagnosis of Cardiac Amyloidosis (CMR for CA)

Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure With Preserved Ejection Fraction | Hypertrophy, Left Ventricular | Heart Failure NYHA Class IV | Cardiac Amyloidosis | Heart Failure With Mid Range Ejection Fraction

Germany
Karolinska Institutet

Completed

Cognitive Behavior Therapy (CBT) for Children With Functional Gastrointestinal Disorders (CBT)

Functional Dyspepsia | Functional Abdominal Pain | Irritable Bowel Syndrome (IBS) | Functional Gastrointestinal Disorders (FGID) | FGID According to the Rome III Criteria

Sweden
Rutgers, The State University of New Jersey

Recruiting

One-month Latent Tuberculosis Treatment for Renal Transplant Candidates

End Stage Renal Disease | Latent Tuberculosis | Renal Transplant Candidate for Right Kidney | Renal Transplant Candidate for Left Kidney

United States
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

Recruiting

Safety & Efficacy of DCR-PHXC in Patients With PH1/2 and ESRD (PHYOX7)

End Stage Renal Disease | Primary Hyperoxaluria Type 2 | Primary Hyperoxaluria Type 1

Germany, Spain, United States, United Kingdom, Italy, United Arab Emirates, Lebanon, Morocco, France, Romania

Clinical Trials on Advanced Stage IIIB

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