Clinical Trials on Alpha-synucleinopathy Related Non-motor Symptom

Total 775 results

Azienda Ospedaliero Universitaria Maggiore della...
Laboratoire THERASCIENCE

Recruiting

Effects of VLCKD in Metabolic Syndrome (KETO-MI)

Obesity | Diabetes Mellitus, Type 2 | Metabolic Syndrome | Non-alcoholic Fatty Liver Disease

Italy
National Eye Institute (NEI)

Recruiting

National Eye Institute Biorepository for Retinal Diseases

Age-Related Macular Degeneration | Diabetic Retinopathy | Retinal Vein Occlusion | Retinal Disease | Von Hippel-Lindau Syndrome

United States
Pfizer

Active, not recruiting

Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 (PROACC-1)

Fatigue | Colorectal Cancer | Pancreatic Cancer | Cachexia | Non-small Cell Lung Cancer | Loss of Appetite

China, United States, Canada, Hungary, Australia, Slovakia, Japan, Taiwan, Bulgaria, Poland, Spain, Czechia
Yan Qiu

Unknown

The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT) (ECT)

Major Depressive Disorder | Depression, Unipolar | Depression, Bipolar | Manic-Depressive - Now Depressed

China
TScan Therapeutics, Inc.

Recruiting

A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors

Melanoma | Cervical Cancer | Head and Neck Cancer | HPV-Related Malignancy | Ovarian Cancer | HPV-Related Carcinoma | HPV-Related Cervical Carcinoma | HPV Positive Oropharyngeal Squamous Cell Carcinoma | Non-small Cell Carcinoma | HPV - Anogenital Human Papilloma Virus Infection | HPV-Related Adenocarcinoma | HPV-Related Adenosquamous Carcinoma and other conditions

United States
Rhode Island Hospital
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Treatments for Psychogenic Nonepileptic Seizures (NES) (NES)

Depression | Stress Disorders, Post-Traumatic | Conversion Disorder | Convulsion, Non-Epileptic

United States
University Health Network, Toronto

Active, not recruiting

FAZA PET/MRI Pancreas

Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Cancer | Pancreatic Adenocarcinoma Non-resectable

Canada
Yonsei University

Completed

Seum Bile Acid Profile in Type 2 Diabetes and Association Between Bile Cid Profile and Adipokine or Oxidative Stress

Metabolic Syndrome | Type 2 Diabetes | Non-alcoholic Fatty Liver Disease | Prediabetes

Korea, Republic of
National Cancer Institute (NCI)

Recruiting

Pomalidomide and Dose-Adjusted EPOCH +/- Rituximab for HIV-Associated Lymphomas

Burkitt Lymphoma | Plasmablastic Lymphoma | Non-Hodgkin Lymphoma | Diffuse Large Cell Lymphoma | B-Cell Neoplasm

United States
Stephanie Wu

Terminated

Debritom - Micro Water Jet Technology and Wound Healing

Diabetic Foot Ulcer | Venous Leg Ulcer | Venous Ulcer | Non-healing Wound | Non-Healing Ulcer of Skin

United States
University of Miami Sylvester Comprehensive Cancer...
The V Foundation for Cancer Research

Recruiting

With Love, Grandma ("Con Cariño, Abuelita") Pilot Study

Obesity | Diet, Healthy | Cancer, Breast | Activity, Motor | Cancer, Uterus | Cancer, Ovary

United States
National Institute of Mental Health (NIMH)

Terminated

PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)

HIV Infections | Healthy | AIDS Dementia Complex | AIDS-Related Dementia Complex | HIV-Associated Cognitive Motor Complex | HIV-Dementia | AIDS Encephalopathy

United States
Black Diamond Therapeutics, Inc.

Recruiting

A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers

Melanoma | Colorectal Cancer | NSCLC | Solid Tumor | Metastatic Lung Cancer | Metastatic Lung Non-Small Cell Carcinoma | Metastatic Melanoma | Non-small Cell Lung Cancer | Histiocytosis | Melanoma (Skin) | Recurrent Melanoma | Thyroid Carcinoma | Thyroid Cancer | Brain Metastases | Recurrent Histiocytic and Dendritic... and other conditions

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Terminated

Phase II Clinical Study of PLM60 for the Treatment of Cutaneous T Cell Lymphomas

Relapsed Cutaneous T Cell Lymphom

China
Bettina Mittendorfer
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Not yet recruiting

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Healthy | Obesity | Diabetes Type 2 | Nonalcoholic Fatty Liver

United States
BioHealing s.r.o.

Completed

AMNIODERM+ Medical Device Clinical Study (AMNIODERM+)

Diabetic Foot | Non-healing Wound

Slovakia
South Tees Hospitals NHS Foundation Trust
Newcastle University; Newcastle-upon-Tyne Hospitals NHS Trust; University of...

Completed

PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer and Lymphoma? (PROACT)

Breast Cancer | Non Hodgkin Lymphoma

United Kingdom
Ningbo No. 1 Hospital

Completed

Weight Gain After Smoking Cessation and NAFLD

Type 2 Diabetes | Nonalcoholic Fatty Liver Disease

China
Karolinska University Hospital

Enrolling by invitation

Low Calorie Diet and Diabetes (LCD)

Obesity | Dyslipidemia | Non-alcoholic Fatty Liver Disease | Diabetes Mellitus Type 2

Sweden
University of California, San Diego

Completed

Non Alcoholic Fatty Liver Disease and Coronary Heart Disease in Type 2 Diabetes Patients

Nonalcoholic Steatohepatitis

United States
Tobira Therapeutics, Inc.

Completed

ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD

Type 2 Diabetes Mellitus | Prediabetic State | Non-alcoholic Fatty Liver Disease

United States, Puerto Rico
Rhode Island Hospital
Stanford University; University of Cincinnati; American Epilepsy Society; Epilepsy...

Completed

Treatment Trial for Psychogenic Nonepileptic Seizures (NEST-T_1)

Depression | Stress Disorders, Post-Traumatic | Dissociative Disorders | Conversion Disorder | Convulsion, Non-Epileptic

United States
Abant Izzet Baysal University

Unknown

A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis

Diabetes Mellitus | Hypercholesterolemia | Coronary Heart Disease | Non-Coronary Atherosclerotic Disease

Turkey
John Sievenpiper
Canadian Institutes of Health Research (CIHR); Canada Research Chairs Endowment... and other collaborators

Unknown

Meta-Analyses of the Effect of Vegetable Protein for Animal Protein on Cardiometabolic Risk

Hypertension | Obesity | Cardiovascular Disease | Diabetes | Overweight | Metabolic Syndrome | Dyslipidemia | Kidney Injury | Prediabetes | Gout | Dysglycemia | Kidney Disease | Non-alcoholic Fatty Liver Disease (NAFLD)

Canada
Shen Qu

Recruiting

Mechanism of Serum PRL in the Development of MAFLD

Type2 Diabetes | Liver Fibrosis | Fatty Liver, Nonalcoholic

China
Hacettepe University

Completed

Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome

PCOS | NAFLD

Turkey
Ocuphire Pharma, Inc.

Completed

Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy (ZETA-1)

Diabetic Retinopathy | Diabetic Macular Edema | NPDR - Non Proliferative Diabetic Retinopathy | PDR - Proliferative Diabetic Retinopathy

United States
Universitätsklinikum Hamburg-Eppendorf

Terminated

Quality of Life After Biliodigestive Anastomosis (BDA) or Stents to Treat Biliary Obstruction in Pancreas Cancer (BYPAPA)

Advanced Cancer | Jaundice | Pancreatic Cancer Non-resectable | Local Tumor Spread | Metastasized

Germany
King Khaled Eye Specialist Hospital

Completed

Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema

Diabetic Macular Edema | Proliferative Diabetic Retinopathy | Non-proliferative Diabetic Retinopathy

Saudi Arabia
Retina Macula Institute
Allergan

Completed

Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema

Diabetic Macular Edema | Proliferative Diabetic Retinopathy | Non-proliferative Diabetic Retinopathy

United States
University of Michigan

Completed

Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients

Obesity | Non-alcoholic Fatty Liver Disease | Diabetes Mellitus Type 2

United States
University of Kelaniya

Completed

The Use of a Community-based Organization to Change Lifestyle Characteristics Related to Non Communicable Diseases

Stroke | Hypertension | Diabetes | Ischemic Heart Disease

Sri Lanka
University of Guadalajara
Instituto Mexicano del Seguro Social

Completed

Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy

Diabetes Mellitus Type 2 | Non-proliferative Diabetic Retinopathy

Mexico
Skane University Hospital

Completed

Nerve Morphology in Diabetic Patients

Diabetes Complications | Carpal Tunnel Syndrome | Peripheral Neuropathy | Entrapment Neuropathies

Sweden
BeBetter Med Inc

Completed

Study of BEBT-908 in Subjects With Advanced Hematological Tumors

Relapsed or Refractory Multiple Myeloma | Relapsed or Refractory Non-Hodgkin's Lymphoma

China
MedImmune LLC

Completed

Safety/Efficacy of MEDI-551 in Combination With Immunomodulating Therapies in Subjects With Aggressive B-cell Lymphomas

Relapsed/Refractory Aggressive B-cell Lymphomas

United States
Memorial Sloan Kettering Cancer Center

Terminated

Improving End of Life Care in Head and Neck Cancer

The Families or Next of Kin of Patients Treated at MSKCC for Non-cutaneous Squamous Cell Carcinomas of the | Upper Aerodigestive Tract

United States
University of Pittsburgh

Recruiting

Longitudinal Study of Neurodegenerative Disorders

Lysosomal Storage Diseases | Leukodystrophy | Niemann-Pick Diseases | Batten Disease | Gaucher Disease | Krabbe Disease | Alpha-Mannosidosis | Osteopetrosis | Tay-Sachs Disease | Pelizaeus-Merzbacher Disease | Sandhoff Disease | GM1 Gangliosidoses | MPS I | MPS II | Vanishing White Matter Disease | Multiple Sulfatase Deficiency... and other conditions

United States
Ciusss de L'Est de l'Île de Montréal

Unknown

Antiminor Histocompatibility Complex (MiHA) T Cells for Patients With Relapsed Hematologic Malignancies Following Matched HSCT (Guided Lymphocyte Immunopeptide Derived Expansion) (GLIDE)

Relapsed Multiple Myeloma | Relapsed Non Hodgkin Lymphoma | Hematologic Cancer | Relapsed Adult AML | Relapse Leukemia | Relapsed Adult ALL | Relapsed CLL | Relapsed Hodgkin's Lymphoma | Relapsed Myelodysplastic Syndromes

Canada
Mayo Clinic

Terminated

Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition (ELT)

Catheter-related Bloodstream Infection (CRBSI) Nos | Bloodstream Infection Due to Central Venous Catheter | Bloodstream Infection Due to Hickman Catheter

United States
New York State Psychiatric Institute
Columbia University

Completed

The Efficacy of Parent Involvement in the Treatment of Adolescent Depression

Major Depressive Disorder | Adjustment Disorder | Dysthymic Disorder | Depressive Disorder NOS

United States
New York State Psychiatric Institute
Columbia University

Completed

Interpersonal Psychotherapy for Depressed Adolescents and Parents

Major Depression | Adjustment Disorders | Dysthymic Disorder | Depressive Disorder Not Otherwise Specified
Immune Design

Completed

A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer

Melanoma | Sarcoma | Breast Cancer | Ovarian Cancer | Non-small Cell Lung Cancer

United States
Haukeland University Hospital
University of Bergen; Helse Stavanger HF; Helse Vest; Forskningsrådet; Folkehelse... and other collaborators

Active, not recruiting

Integrated Treatment of Hepatitis C Virus Infection (INTRO-HCV)

Hepatitis C, Chronic | Opioid Dependence, on Agonist Therapy

Norway
Stanford University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Obesity | Diabetes Mellitus, Type 2 | Insulin Resistance | PreDiabetes | Diet Modification | Nonalcoholic Steatohepatitis | Nonalcoholic Fatty Liver

United States
University of Missouri-Columbia

Recruiting

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Non-small Cell Lung Cancer | Hepatocellular Cancer

United States
Eisai Inc.

Completed

A Study of Remitoro in Participants With Recurrent or Refractory Peripheral T Cell Lymphoma and Cutaneous T Cell Lymphoma (All Case Study)

Lymphoma, T-cell, Peripheral | Lymphoma, T-cell, Cutaneous

Japan
University of Toronto
Canadian Diabetes Association; The Physicians' Services Incorporated Foundation and other collaborators

Unknown

Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors

Hypertension | Cardiovascular Disease | Diabetes | Dyslipidemia | Non-alcoholic Fatty Liver Disease | Prediabetes | Gout | Dysglycemia

Canada
Incyte Corporation

Terminated

An Open-Label Study of a Novel JAK-inhibitor, INCB047986, Given in Patients With Advanced Malignancies

Breast Cancer | Pancreatic Cancer | Hodgkin's Lymphoma | Solid Tumor | Metastatic Cancer | Advanced Cancer | NHL (Non-Hodgkin Lymphoma) | UC (Ureter and Urethera)

United States
Conatus Pharmaceuticals Inc.

Terminated

Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF

Liver Cirrhosis | Acute on Chronic Hepatic Failure | Acute Liver Failure | Acute Alcoholic Hepatitis

United States, United Kingdom

Clinical Trials on Alpha-synucleinopathy Related Non-motor Symptom

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Uzbekistan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations