Search clinical trials for: APL-130277

Total 255433 results

Shanghai YingLi Pharmaceutical Co. Ltd.

Recruiting

A Phase 1b/2 Study of YL-13027 Combined With Sintilimab in Patients With Advanced Solid Tumors

Advanced Solid Tumors

China
Shanghai YingLi Pharmaceutical Co. Ltd.
Yingli Pharma US, Inc

Recruiting

YL-13027 in Patients With Advanced Solid Tumors

Solid Tumor

United States
Shanghai YingLi Pharmaceutical Co. Ltd.

Recruiting

First in Human Dose Escalation Study of YL-13027 in Subjects With Advanced Stage Solid Tumors

Advanced Solid Tumors

China
Guerbet

Completed

Pharmacokinetics, Safety and Efficacy of P03277 in Pediatric Patients Undergoing Central Nervous System Contrast-enhanced MRI

Pediatric Patients | Central Nervous System Indication | Body Indication

Bulgaria, Hungary, Poland, Slovakia, Ukraine
Guerbet

Completed

Pharmacokinetics, Dialysability and Safety of P03277 in Healthy Volunteers and in Patients With Impaired Renal Function

Renal Insufficiency | Healthy Volunteers

Moldova, Republic of, Romania
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Evaluate ACT-132577 in Healthy Subjects and in People With Severe Kidney Disease

Healthy Subjects | Severe Renal Impairment

Czechia
Vividion Therapeutics, Inc.

Recruiting

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors

Advanced Solid Tumors

United States, Spain
Idorsia Pharmaceuticals Ltd.

Completed

Clinical Study to Assess Body Fluid Homeostasis After Administration of ACT-132577 in Healthy Subjects

Healthy Subjects

Switzerland
Idorsia Pharmaceuticals Ltd.
Janssen Biotech, Inc.

Withdrawn

A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease. (INSPIRE-CKD)

Hypertension | Renal Insufficiency, Chronic
Guerbet

Completed

P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)

Blood Brain Barrier Defect | CNS Lesion

Korea, Republic of, United States, Czechia, Italy, Belgium, Poland, Hungary, Mexico
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Evaluate ACT-132577 in Healthy Male Subjects

Healthy Subjects

Netherlands
Guerbet

Completed

Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions

Healthy Volunteers | Brain Lesion

Belgium
KU Leuven

Completed

Irritable Bowel Syndrome (IBS) Treatment With H1-receptor Antagonists

Irritable Bowel Syndrome

Belgium
Idorsia Pharmaceuticals Ltd.

Completed

The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics

Healthy Subjects | Hepatic Impairment

Germany, Poland
Idorsia Pharmaceuticals Ltd.

Completed

Bioequivalence Study of Different Aprocitentan Tablet Formulations

Healthy Subjects

Czechia
Guerbet

Completed

Proof of Concept Study Concerning Efficacy of P03277 MR Imaging in HCC Diagnosis

Chronic Liver Disease | HepatoCellular Carcinoma

France
Concert Pharmaceuticals

Completed

Pharmacokinetics, Safety & Tolerability of Isotopologs of Atazanavir (ATV), With Pharmacokinetic Comparison to Reyataz

Healthy Volunteers
Sunovion

Completed

A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug Containing Apomorphine or Apomorphine That is Injected Under the Skin in People With PD Complicated by "OFF" Episodes

Parkinson Disease

United States
Idorsia Pharmaceuticals Ltd.
Janssen Biotech, Inc.

Completed

A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety (PRECISION)

Resistant Hypertension

Spain, Israel, Czechia, United States, Canada, China, Hungary, Netherlands, Poland, United Kingdom, Germany, Australia, Belgium, Finland, France, Greece, Italy, Lithuania, Russian Federation, Ukraine
Johnson & Johnson Consumer and Personal Products...

Completed

Tooth Sensitivity Relief by Two Mouthrinses

Dentin Sensitivity

United States
Orion Corporation, Orion Pharma

Completed

Suitability of 11C-ORM-13070 as a PET Tracer

Healthy

Finland
VGX Pharmaceuticals, LLC
GeneOne Life Science, Inc.

Completed

Phase I Safety and Pharmacokinetic Study of VGX-1027 in Healthy Subjects

Healthy

United States
Gilead Sciences

Completed

A Phase 1a Trial Assessing the Safety, Tolerability, and Immunogenicity of GS-4774 (GI-13020) at Various Dose Levels and Regimens in Healthy Adults

Healthy Volunteers

United States
Ichnos Sciences SA
Glenmark Pharmaceuticals S.A.

Terminated

Study of ISB 1302 (CD3 Bispecific Ab) in HER2-positive Metastatic Breast Cancer

Breast Cancer

United States
Sunovion

Completed

A Study to Examine APL-130277 in Patients With Parkinson's Disease

Parkinson's Disease

United States
GeneOne Life Science, Inc.

Active, not recruiting

GLS-1027 for the Prevention of Severe Pneumonitis Caused by SARS-CoV-2 Infection (COVID-19)

SARS-CoV Infection | Pneumonitis

Korea, Republic of, Puerto Rico, United States, Bulgaria, North Macedonia
VGX Pharmaceuticals, LLC
GeneOne Life Science, Inc.

Completed

Multiple-Dose Study of VGX-1027 in Healthy Subjects

Healthy

United States
Sunovion

Completed

A Study of an Investigational Drug to See How it Affects the People With Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes) Compared to an Approved Drug Used to Treat People With Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes)

Motor OFF Episodes Associated With Parkinson's Disease

Spain, United Kingdom, Germany, Italy, Austria, France
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Investigate the Effect of ACT-132577 on the Pharmacokinetics of Midazolam and 1-hydroxy Midazolam in Healthy Male Subjects

Healthy Subjects

United States
Sumitomo Pharma America, Inc.

Completed

Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease

Parkinson Disease

United States, Spain, United Kingdom, Italy, Canada, Austria, France, Germany
Sunovion

Completed

Efficacy, Safety and Tolerability Study of APL-130277 for the Acute Treatment of OFF Episodes in Patients With Parkinson's Disease

Parkinson Disease, Off Episodes

United States, Canada
Conatus Pharmaceuticals Inc.
FGK Clinical Research GmbH

Completed

Study of CTS-1027 in Hepatitis C Patients

Chronic Hepatitis C Virus Infection

United States
Celldex Therapeutics

Completed

Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer (CDX1307-02)

Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Bladder Cancer

United States
Guerbet

Completed

Cardiac Safety Evaluation of P03277

Healthy Volunteers

Belgium
Celldex Therapeutics

Terminated

A Study of the CDX-1307 Vaccine Regimen in Patients With Newly Diagnosed Muscle-Invasive Bladder Cancer (The "N-ABLE" Study)

Bladder Cancer

United States
Sunovion

Completed

A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes

Parkinson's Disease | Off Episodes of Parkinson Disease

United States, Italy
Johnson & Johnson Consumer and Personal Products...

Completed

Oral Irritation Study of Two Experimental Mouthrinses

Oral Manifestations

United States
M.D. Anderson Cancer Center
280Bio Inc

Recruiting

A Trial of YL-13027 in Combination With Gemcitabine and Nab-paclitaxel in Patients With Refractory Metastatic Pancreatic Cancer

Metastatic Pancreatic Cancer

United States
Zydus Lifesciences Limited

Not yet recruiting

A Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Immunogenicity of Test Pertuzumab (ZRC-3277, Cadila Healthcare Ltd.,)

Metastatic Breast Cancer
Idorsia Pharmaceuticals Ltd.

Completed

A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-132577 Can Affect Rosuvastatin's Fate in the Body (Amount and Time of Presence in the Blood)

Healthy Subjects

Czechia
National Cancer Institute (NCI)

Completed

CCI-779 and Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney Cancer

Clear Cell Renal Cell Carcinoma | Stage IV Renal Cell Cancer | Recurrent Renal Cell Cancer

United States
Cougar Biotechnology, Inc.

Terminated

A Study of Noscapine HCl (CB3304 ) in Patients With Relapsed or Refractory Multiple Myeloma

Refractory Multiple Myeloma

United States
Paracelsus Medical University
Salzburger Landeskliniken

Completed

Comparison of High Tone Therapy and TENS Therapy (HIT-CIPN)

Peripheral Nervous System Problem

Austria
Johnson & Johnson Consumer and Personal Products...

Completed

Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity

Dentin Sensitivity

United States
Vienna General Hospital

Completed

PTA vs. Primary Stenting of SFA Using Self-Expandable Nitinol Stents

Peripheral Vascular Diseases | Intermittent Claudication | Angioplasty

Austria
Conatus Pharmaceuticals Inc.

Completed

CTS-1027 in Interferon-Naive Hepatitis C Patients

Hepatitis C

United States, Puerto Rico
Icahn School of Medicine at Mount Sinai
Bausch Health Americas, Inc.

Completed

Perimenstrual Acne With Clindamycin Phosphate and Benzoyl Peroxide

Actinic Keratosis

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide

Hypertension

United States
Conatus Pharmaceuticals Inc.

Completed

Study of CTS-1027 in Combination With Pegylated Interferon and Ribavirin in Hepatitis C Virus (HCV) Null-Responders (CTS-1027-04)

Hepatitis C

United States, Puerto Rico
Idorsia Pharmaceuticals Ltd.

Completed

Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension

Essential Hypertension

United States, Canada, Israel, Puerto Rico

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