Clinical Trials on Anal Injury

Total 10382 results

ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer (InterAACT)

Anal Squamous Cell Carcinoma | Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Metastatic Anal Canal Carcinoma | Recurrent Anal Canal Carcinoma | Stage IIIB Anal Canal Cancer | Stage IV Anal Canal Cancer

United States
Sun Yat-sen University

Enrolling by invitation

PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy for Locally Advanced SCCA Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage I | Anal Canal Cancer Stage II | Anal Canal Cancer Stage III

China
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

Anal Canal Squamous Cell Carcinoma | Metastatic Anal Canal Carcinoma | Stage IV Anal Canal Cancer AJCC v6 and v7

United States, Canada
Poitiers University Hospital

Recruiting

Reproducibility of External Anal Sphincter Elastic Properties Assessment Using Elastography During Pregnancy (SEA ELASTO 1)

Obstetric Anal Sphincter Injury

France
Croydon University Hospital

Completed

Use of 3D Ultrasound to Predict Anal Sphincter Defects

Obstetric Anal Sphincter Injury
Chinese University of Hong Kong

Recruiting

Prevalence of Obstetric Anal Sphincter Injury With a Reducing Episiotomy Rate

Anal Sphincter Injury

Hong Kong
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Anal Canal Squamous Cell Carcinoma | Anal Margin Squamous Cell Carcinoma | Stage I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Lewisham and Greenwich NHS Trust

Completed

Diagnosis of Obstetric Anal Sphincter Injuries (OASIs) Using Transperineal Ultrasound Scan (TPUS)

Obstetric Anal Sphincter Injury

United Kingdom
Lena Sagi-Dain
Rambam Health Care Campus; Hillel Yaffe Medical Center; Bnai Zion Medical Center and other collaborators

Terminated

The Effect of Episiotomy on Maternal and Fetal Outcomes (EPITRIAL)

Anal Sphincter Injury

Israel
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage III

China
Northwestern University
Evergreen Invitational

Completed

Vaginal Electrical Stimulation for Postpartum Neuromuscular Recovery (VESPR)

Obstetric Anal Sphincter Injury | Vaginal Electrical Stimulation

United States
Mansoura University

Completed

Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy

Hypertensive Anal Canal

Egypt
University Hospital, Angers

Not yet recruiting

Anal Incontinence After Obstetrical Anal Sphincter Injury (INCONT-LOSA)

Anal Sphincter Injury | Anal Incontinence | Obstetric Trauma
OASIS Diagnostics S.A.

Completed

Impedance Spectroscopy in Detection of Obstetric Anal Sphincter Injuries

Delivery, Obstetric | Obstetric Anal Sphincter Injury

Poland
University of California, Irvine

Completed

3-D Endoanal Ultrasound: Normative Anatomy of the Anal Sphincter in Nulliparous Females

Normal (no Known Injury) Anal Sphincter Female Anatomy

United States
OASIS Diagnostics S.A.

Completed

Impedance Spectroscopy for Obstetric Anal Sphincter Injuries Detection

Obstetric Complication | Delivery Complication | Obstetric Anal Sphincter Injury

Poland
University of Turku
Medtronic

Completed

External Phase MRI in Diagnosis of OASI

Anal Sphincter Injury | Obstetrics Trauma
AHS Cancer Control Alberta

Unknown

A Phase II Study to Assess Acute Toxicity and Quality of Life of Patients With Carcinoma of the Anal Canal Receiving Chemotherapy and Radiation Using Helical Tomotherapy

Anal Canal Cancer

Canada
Assiut University

Recruiting

Traumatic Anal Sphincteric Injury Immediate vs Delayed Repair

Traumatic Anal Sphincteric Injury,Immediate vs Delayed Repair

Egypt
London North West Healthcare NHS Trust

Completed

Primary Repair of Obstetric Anal Sphincter Injuries (OASIS) by Surgeons (PROS Study) (PROS)

Obstetric Anal Sphincter Injury

United Kingdom
OASIS Diagnostics S.A.
National Center for Research and Development, Poland

Completed

Detection of Obstetric Anal Sphincter Injuries With ONIRY Device

Obstetric Complication | Delivery Complication | Obstetric Anal Sphincter Injury

Spain, Czechia, Poland, Slovakia
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
Institut Cancerologie de l'Ouest

Completed

Medico-economic Evaluation Comparing Intensity-Modulated Radiation Therapy (IMRT) Performed by Helical Tomotherapy and Dynamic Arc Therapy in Prostate, Cervical and Anal Canal Cancers (RCMI PELVIS)

Cervical Cancer | Prostate Cancer | Anal Canal Cancers

France
Dr. Te Vuong
YM BioSciences

Terminated

Nimotuzumab With Radiotherapy in the Treatment of Anal Canal Cancers

Squamous Cell Carcinoma of Anal Canal

Canada
Centre Francois Baclesse
Accuray Incorporated

Active, not recruiting

Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life (CANAL-IMRT-01)

Locally Advanced Anal Canal Cancer

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial

Stage III Anal Cancer AJCC v8 | Anal Canal Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Groupe Hospitalier Paris Saint Joseph

Completed

Pelvic-perineal Disorders in Women With Sphincter Tears (PAPOASI)

Obstetrical Perineal Injury and Anal Incontinence

France
Centre Hospitalier Universitaire de Besancon

Completed

Evaluation of Immune Response Against Human Papillomavirus (HPV)in Patients With Metastatic Cancer of the Anal Canal (Epitopes-HPV01)

Metastatic Anal Canal Cancer | Human Papillomavirus

France
Centre Hospitalier Universitaire de Besancon

Withdrawn

Immunomonitoring and Biomarker Research in Patients With Squamous Cell Anal Carcinoma (LAND)

Anal Canal Cancer

France
National Cancer Institute (NCI)

Recruiting

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Anal Canal Cloacogenic Carcinoma | Metastatic Anal Squamous Cell Carcinoma | Recurrent Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IV Anal Cancer AJCC v8 | Unresectable Anal Squamous Cell Carcinoma | Anal Basaloid Squamous Cell Carcinoma

United States
AHS Cancer Control Alberta

Recruiting

Inguinal Node Sparing Radiotherapy For Patients With Early Stage Anal Cancer (INSPIRE)

Anal Canal Cancer

Canada
National Cancer Institute (NCI)
Canadian Cancer Trials Group

Active, not recruiting

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Anal Basaloid Squamous Cell Carcinoma

United States, Canada
Hospital General de México Dr. Eduardo Liceaga

Unknown

Anal Injury Screening for High Risk HPV (AnalTest)

Anal Cancer | Anal Injury

Mexico
Croydon Health Services NHS Trust

Completed

The Effect of Perineal Wound Infection on the Anal Sphincter

Anal Sphincter Injury | Obstetric Trauma | Perineal Infection | Perineum; Injury

United Kingdom
Hadassah Medical Organization

Completed

Risk Factors for Anal Sphincter Damage During Vaginal Delivery (AnaSphRF)

Anal Sphincter Injury | Fecal Incontinence

Israel
Massachusetts General Hospital
National Cancer Institute (NCI)

Unknown

Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma

Carcinoma of the Anal Canal

United States
Poitiers University Hospital

Recruiting

Mediolateral Episiotomy and Obstetric Anal Sphincter Injuries in Instrumental Delivery (INSTRUMODA)

Depression | Pelvic Floor Disorders | Anal Incontinence | Episiotomy Wound | Obstetric Anal Sphincter Injury

France
National Cancer Institute (NCI)

Recruiting

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV Infection | Anal Squamous Cell Carcinoma | Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | AIDS-Related Anal Carcinoma | Rectal Squamous Cell Carcinoma | Stage I Anal Cancer AJCC... and other conditions

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; AIDS and Cancer Specimen Resource

Active, not recruiting

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

HIV Infection | Anal Squamous Cell Carcinoma | Stage 0 Anal Canal Cancer | Stage I Anal Canal Cancer

United States
Instituto do Cancer do Estado de São Paulo

Completed

A Study of Substitution of 5-FU (Fluorouracil) by Capecitabine in Scheme of Chemo-radiotherapy in Patients With Squamous Cell Carcinoma of the Anal Canal.

Anal Canal Cancer.

Brazil
London North West Healthcare NHS Trust

Recruiting

CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence (CArE for OAsI)

Anal Incontinence | Faecal Incontinence | Follow-up | Biofeedback | Obstetric Anal Sphincter Injury | Urogynaecology | Urgency | Severe Perineal Trauma | Grade 3 Perineal Tear | Grade 4 Perineal Tear | Deferral Time | Pathways | Review | Endo-anal Ultrasound

United Kingdom
Centre Hospitalier Universitaire Vaudois

Terminated

Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine, Mitomycin and Panitumumab in Patients With Stage II-IIIB Squamous-cell Carcinoma of the Anal Canal

Carcinoma of Anal Canal

Switzerland
Laser Surgery Care
QIAGEN Gaithersburg, Inc

Completed

Hybrid Capture 2 Human Papiloma Virus (HPV) High-Risk Anal DNA Test

Anal Cancer | Anal Canal HPV Infection Diagnosis | Anal Dysplasia Diagnosis

United States
Incyte Corporation

Completed

A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)

Squamous Cell Carcinoma of Anal Canal

Spain, United Kingdom, United States, Germany, Belgium, France, Denmark, Italy, Norway
Centre Hospitalier Universitaire de Besancon

Completed

Clinical and Biological Interest of Taxanes in Advanced Squamous Cell Anal Carcinoma (Epitopes-HPV02)

Anal Canal Carcinoma

France
Boehringer Ingelheim

Withdrawn

A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have Advanced Anal Cancer

Anal Canal Squamous Cell Carcinoma

Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

4-Point Therapy Response Score With PET/CT for Anal Squamous Cell Cancer

Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8 | Stage 0 Anal Cancer...

United States
The Cleveland Clinic
Bard Ltd

Completed

Comparative Study Between Two Fecal Management Systems

Anal Erosion

United States
Hospices Civils de Lyon

Completed

Assessment of the Predictive Value of the Acetic Acid Test in Surgery Condition for the Detection of Dysplastic Lesions in Patients With Anal Condylomatosis

Anal Condyloma

France
Grupo Espanol Multidisciplinario del Cancer Digestivo
Hoffmann-La Roche

Recruiting

Tiraglolumab Atezolizumab and Chemoradiotherapy in Localized Anal Carcinoma (TIRANUS) (TIRANUS)

Squamous Cell Carcinoma of the Anal Canal

Spain

Clinical Trials on Anal Injury

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