Clinical Trials on Aplasia

Total 4813 results

National Cancer Institute (NCI)

Active, not recruiting

Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
Loxo Oncology, Inc.

Available

Expanded Access Program for Pirtobrutinib for Participants With B-Cell Cancer

Lymphoma, Mantle-Cell | Waldenstrom Macroglobulinemia | Leukemia, Lymphocytic, Chronic, B-Cell | Lymphoma, Lymphocytic, Small | Ritcher's Transformation, Syndrome
Dartmouth-Hitchcock Medical Center

Active, not recruiting

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Lymphoma | Lymphoma, Non-Hodgkin | Acute Myeloid Leukemia | Myelofibrosis | Chronic Lymphocytic Leukemia | Chronic Myeloid Leukemia | Myelodysplasia | Myeloproliferative Disorder | Plasma Cell Disorder

United States
Amgen

Completed

Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.

Bone Metastases
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Active, not recruiting

Cytogenetic Studies in Acute Leukemia and Multiple Myeloma

Multiple Myeloma | Acute Lymphoblastic Leukemia | Acute Leukemia | Myelodysplastic Syndrome

United States
University of Michigan Rogel Cancer Center

Terminated

Pacritinib in Relapsed/Refractory Lymphoproliferative Disorders

Lymphoproliferative Disorders | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Lymphoma, T-Cell, Cutaneous | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Lymphoma, T-Cell, Peripheral

United States
Celgene
The Leukemia and Lymphoma Society

Completed

Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia

Waldenstrom Macroglobulinemia | Chronic Lymphocytic Leukemia | B Cell Non-Hodgkin's Lymphoma

United States
Cancer Research UK

Completed

A Phase I Trial of DI-B4 in Patients With Advanced CD19 Positive Indolent B-cell Malignancies

Chronic Lymphocytic Leukaemia | Indolent B-cell Lymphoma | Waldenström Macroglobulinaemia

United Kingdom
Tragara Pharmaceuticals, Inc.

Completed

Phase 1 Study of TG02 Citrate in Patients With Advanced Hematological Malignancies (TG02-101)

Multiple Myeloma | AML | Blast Crisis | MDS | ALL

United States
University Hospital, Antwerp

Unknown

Efficacy of Dendritic Cell Therapy for Myeloid Leukemia and Myeloma

Acute Myeloid Leukemia | Multiple Myeloma | Chronic Myeloid Leukemia

Belgium
National Cancer Institute (NCI)

Completed

Sorafenib and Bortezomib in Treating Patients With Advanced Cancer

Stage III Multiple Myeloma | Unspecified Adult Solid Tumor, Protocol Specific | Refractory Multiple Myeloma | Refractory Chronic Lymphocytic Leukemia | Stage IV Chronic Lymphocytic Leukemia

United States
Children's Hospital Medical Center, Cincinnati

Recruiting

Time-restricted Feeding to Reduce Inflammation in Fanconi Anemia

Fanconi Anemia

United States
Rocket Pharmaceuticals Inc.

Active, not recruiting

Gene Therapy for Fanconi Anemia, Complementation Group A

Fanconi Anemia Complementation Group A

United States
Boston Children's Hospital

Terminated

Safety and Efficacy Trial of Danazol in Patients With Fanconi Anemia or Dyskeratosis Congenita

Fanconi Anemia | Dyskeratosis Congenita

United States
Columbia University

Unknown

Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases

Severe Combined Immunodeficiency | Fanconi Anemia | Bone Marrow Failure | Osteopetrosis

United States
Scripps Translational Science Institute
Cue Health

Recruiting

ImmunoCARE: Rapid, Accurate COVID Testing to Reduce Hospitalization of Immunocompromised Individuals

HIV Infections | Lymphoma | Leukemia | Cancer | Multiple Myeloma | Immunosuppression | Immunodeficiency | Transplant | Graft Versus Host Disease | Age-Related Immunodeficiency

United States
Amgen
Daiichi Sankyo, Inc.

Completed

Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma

Cancer | Multiple Myeloma | Bone Metastases | Hematologic Malignancies | Oncology | Multiple Myeloma Bone Lesions

United States, Germany, Italy, Spain, Canada, France, Czechia, Hungary, Korea, Republic of, Russian Federation, United Kingdom, Taiwan, Australia, Hong Kong, New Zealand, Austria, Slovakia, Portugal, Greece, Bulgaria, Poland, Ukraine and more
Novartis Pharmaceuticals

Terminated

Ceritinib Rare Indications Study in ALK+ Tumors

Glioblastoma | Anaplastic Large Cell Lymphoma | Inflammatory Myofibroblastic Tumor | Tumors With Aberrations in ALK

France, Czechia, Italy, Spain, Korea, Republic of, Thailand, Israel, Denmark
National Cancer Institute (NCI)

Withdrawn

Providing Access to Cord Blood Units for Transplants

Multiple Myeloma | Non-Hodgkin Lymphoma | Acute Leukemias | Chronic Myelogous Leukemia/Other Leukemia | MDS/MPS
National Cancer Institute (NCI)

Completed

Flavopiridol in Treating Patients With Previously Treated Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma

Waldenström Macroglobulinemia | Recurrent Small Lymphocytic Lymphoma | B-cell Chronic Lymphocytic Leukemia | Refractory Chronic Lymphocytic Leukemia

United States
Washington University School of Medicine

Completed

Plerixafor and Sargramostim (GM-CSF) for Mobilization of Allogeneic Sibling Donors

Lymphoma, Non-Hodgkin | Myelodysplastic Syndromes | Leukemia, Myeloid, Acute | Multiple Myeloma | Hodgkin Disease | Leukemia, Lymphocytic, Chronic, B-Cell

United States
H. Lee Moffitt Cancer Center and Research Institute
Reliable Cancer Therapies

Terminated

Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain

Pain | Lymphoma | Cancer | Neoplasm Metastasis | Multiple Myeloma | Hematologic Malignancy | Tumor | Unresectable Malignant Neoplasm | Malignant Solid Tumor

United States
Bayer

Completed

Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment (BONA)

Breast Neoplasms | Prostatic Neoplasms | Multiple Myeloma | Osteolysis

Czech Republic
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Early Assessment of Cardiac Function After Treatment With CAR-T Cells (Cardio CAR-T)

Lymphoma, B-Cell | Multiple Myeloma | Acute Lymphoblastic Leukemia | Hematologic Malignancy | Car T- Cell

France
National Cancer Institute (NCI)

Active, not recruiting

Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer

Hodgkin Disease | Waldenstrom Macroglobulinemia | Chronic Lymphocytic Leukemia | NonHodgkin Lymphoma | Mixed Lymphoproliferative Disease

United States
Memorial Sloan Kettering Cancer Center

Completed

HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

Multiple Myeloma | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Acute Myelogenous Leukemia

United States
Margarida Magalhaes-Silverman
National Cancer Institute (NCI)

Completed

Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma

Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Primary Systemic Amyloidosis | Light Chain Deposition Disease | Extramedullary Plasmacytoma | Isolated Plasmacytoma of Bone

United States
Oncoethix GmbH

Completed

A Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX015/ Birabresib (MK-8628) in Hematologic Malignancies (MK-8628-001)

Acute Myeloid Leukemia | Multiple Myeloma | Acute Lymphoblastic Leukemia | Diffuse Large B-cell Lymphoma
Memorial Sloan Kettering Cancer Center
Millennium Pharmaceuticals, Inc.

Completed

Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis

Amyloidosis | Light Chain Deposition Disease (LCDD or MIDD) | Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD) | Monoclonal Immunoglobulin Deposition Disease (MIDD)

United States
University of Washington
National Cancer Institute (NCI)

Terminated

Carfilzomib With or Without Rituximab in the Treatment of Waldenstrom Macroglobulinemia or Marginal Zone Lymphoma

Recurrent Marginal Zone Lymphoma | Waldenstrom Macroglobulinemia | Marginal Zone Lymphoma | Refractory Marginal Zone Lymphoma | Recurrent Waldenstrom Macroglobulinemia | Refractory Waldenstrom Macroglobulinemia

United States
Masonic Cancer Center, University of Minnesota
Pfizer

Terminated

Study of Immune Response Modifier in the Treatment of Hematologic Malignancies

Acute Myeloid Leukemia | Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood Cancers

Multiple Myeloma | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | Graft vs Host Disease | Hematologic Neoplasm

United States
Washington University School of Medicine

Completed

Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation (GVHD)

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute | Multiple Myeloma | Leukemia, Myelogenous, Chronic

United States
Alaunos Therapeutics

Completed

A Phase I Trial of ZIO-101 in Hematologic Cancers

Lymphoma | Multiple Myeloma | Acute Leukemia | Chronic Myeloproliferative Disease | Chronic Lymphoproliferative Disease | Poor-risk Myelodysplasia (MDS)

United States
Bristol-Myers Squibb

Withdrawn

Safety Study of Anti-Programmed Death-Ligand 1 in Hematologic Malignancy

Multiple Myeloma | Hodgkin Lymphoma | Non-Hodgkin's Lymphoma | Chronic Myelogenous Leukemia
Novartis

Completed

Treatment With Zoledronic Acid in Patients With Breast Cancer, Multiple Myeloma, and Prostate Cancer With Cancer Related Bone Lesions

Breast Cancer | Multiple Myeloma | Prostate Cancer

United States
Merck Sharp & Dohme LLC

Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Non-Hodgkins Lymphoma | Hematologic Malignancies | Chronic Lymphocytic Leukaemia | Waldenstroms Macroglobulinaemia

Poland, United States, Argentina, Australia, Brazil, Canada, France, Israel, Italy, Spain, Switzerland, Turkey, United Kingdom, Korea, Republic of, Germany, Denmark, China, Romania, Czechia, Hungary, Ireland, Ukraine
Mundipharma Research Limited

Active, not recruiting

Study of Tinostamustine, First-in-Class Alkylating HDACi Fusion Molecule, in Relapsed/Refractory Hematologic Malignancies

Multiple Myeloma | Hodgkin's Lymphoma | Hematological Malignancies | Cutaneous T Cell Lymphoma

France, United States, Netherlands, Spain, Switzerland, Germany, Italy
University of Arizona
National Cancer Institute (NCI)

Terminated

Pentostatin and Alemtuzumab as a Preparative Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation

Lymphoma | Carcinoma, Renal Cell | Leukemia | Hematologic Neoplasms | Multiple Myeloma | Hodgkin's Disease

United States
Marshall University
Edwards Foundation, Inc.

Terminated

Prevention of Disease Progression in Early Stage Indolent B Cell Malignancies. (SMM)

Chronic Lymphocytic Leukemia | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Massachusetts General Hospital

Not yet recruiting

Covid-19 Vaccine Responsiveness in MM and Waldenstrom

Covid19 | Multiple Myeloma | Waldenstrom Macroglobulinemia | Immune System Disorder

United States
Memorial Sloan Kettering Cancer Center
Montefiore Medical Center; St. Jude Children's Research Hospital

Recruiting

Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

Lymphoma | Leukemia | Multiple Myeloma | Colon Cancer | Renal Cancer

United States
University of Rochester
GlaxoSmithKline

Completed

Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors

Chronic Lymphocytic Leukemia (CLL) | Waldenstrom Macroglobulinemia (WM)

United States
Adaptive Biotechnologies

Active, not recruiting

The clonoSEQ® Watch Registry

Multiple Myeloma | Chronic Lymphocytic Leukemia | Non-hodgkin Lymphoma | Acute Lymphoblastic Leukemia, Adult B-Cell

United States
Dana-Farber Cancer Institute
Eli Lilly and Company

Withdrawn

ERK 1/2 Signaling in Ibrutinib Resistant B-cell Malignancies

Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia
University of Florida
Gateway for Cancer Research; Cellworks Group Inc.

Terminated

iCare for Cancer Patients

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Multiple Myeloma | Myelofibrosis | Acute Myelogenous Leukemia | Acute Lymphoid Leukemia | Leukemia, Acute Lymphoblastic

United States
Timmune Biotech Inc.
Hunan Provincial People's Hospital

Unknown

Treatment of Hematological Malignancy With Novel CAR-T Cells.

Multiple Myeloma | B-cell Acute Lymphoblastic Leukemia | B-cell Non Hodgkin Lymphoma

China
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Collection of Patient-Reported Symptoms and Performance Status Via the Internet

Leukemia | Breast Cancer | Multiple Myeloma | Colorectal Cancer | Lung Cancer | Prostate Cancer

United States
Celgene Corporation

Terminated

Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Multiple Myeloma | Hodgkin Lymphoma | Chronic Myelomonocytic Leukemia | Non-Hodgkin Lymphoma

Japan
Colorado Blood Cancer Institute

Unknown

Tacrolimus and MMF as Post Grafting Immunosuppression After Conditioning With Flu TBI for HLA Matched Family Donor

Lymphoma | Multiple Myeloma | Myelodysplastic Syndrome | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia

United States

Clinical Trials on Aplasia

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