Clinical Trials on BRCA1 Gene Mutation

Total 1934 results

Intergroupe Francophone de Cancerologie Thoracique

Active, not recruiting

Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation (ORBITAL)

Non Small Cell Lung Cancer Metastatic | Brain Metastases | EGFR Activating Mutation | Leptomeningeal Metastasis

France
Enzyvant Therapeutics GmBH

Completed

Farber Disease Natural History Study

Farber Disease | Farber's Disease | Farber Lipogranulomatosis | Acid Ceramidase Deficiency | Ceramidase Deficiency | N-Laurylsphingosine Deacylase Deficiency | ASAH1 Mutation

United States, Egypt, Canada, Italy, Turkey, Argentina, Germany, India, Sweden
Norwegian School of Sport Sciences
Norwegian University of Science and Technology; Sunnaas Rehabilitation Hospital and other collaborators

Recruiting

Intervention on Bone Health in Wheelchair Users (BoneWheel)

Cerebral Palsy | Amputation | Bone Loss | Spinal Cord Injuries | Spina Bifida | Dysmelia

Norway
University Health Network, Toronto

Not yet recruiting

Diabetic Foot Care and Limb Preservation Pathway: Developmental Evaluation Study

Diabetes | Diabetic Foot | Amputation | Lower Limb Wound
Princess Nourah Bint Abdulrahman University
King Faisal Specialist Hospital & Research Center; King Fahad Hospital

Recruiting

Estimating Length of Endotracheal Tube Insertion Using Gestational Age or Nasal-Tragus Length in Newborn Infants (ELEGANT)

Pneumothorax | Death | Bronchopulmonary Dysplasia | Endotracheal Tube Tip Position | Duration, Ventilator

Saudi Arabia
New York State Psychiatric Institute

Completed

Treating Self Injurious Behavior: A Novel Brain Stimulation Approach

Depression | Bipolar Disorder | Self-Injurious Behavior | Borderline Personality Disorder | Self Harm | Non-Suicidal Self Injury | Self Injurious Behavior Without Suicidal Intent | Self-inflicted Injury | Self-injury | Non Suicidal Self Inflicted Injury | Cutting

United States
3M

Terminated

A Study Comparing V.A.C. Negative Pressure Wound Therapy (NPWT) to Moist Wound Therapy (MWT) in the Treatment of Diabetic Foot Amputation Wounds (VAC 2006-19)

Diabetic Amputation Foot Wound
Tampere University Hospital

Recruiting

Toe Amputations in Patients With Diabetes (PANDORAT)

Infections | Diabetic Foot | Amputation

Finland
Center for Bionics and Pain Research
Massachusetts General Hospital; Göteborg University; University of Michigan; University... and other collaborators

Recruiting

Surgical Treatments for Postamputation Pain

Phantom Limb Pain | Pain, Neuropathic | Amputation Neuroma | Residual Limb Pain | Pain, Nerve

United States, Canada, Australia, Chile, Italy, Sweden, United Kingdom
University of Nove de Julho
Daniela de Fátima Teixeira da Silva; Monica Ribeiro Ventura

Withdrawn

Phototherapy in DM Amputation Ulcers.

Diabetes Mellitus | Diabetic Foot | Amputation Stumps

Brazil
Sarcoma Oncology Research Center, LLC
Aadi Bioscience, Inc.

Completed

Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers

Melanoma | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | Ewing Sarcoma | Non Small Cell Lung Cancer | Chordoma | Urothelial Carcinoma | Classical Hodgkin Lymphoma | PEComa | Desmoid Tumor | Epithelioid Sarcoma | Squamous Cell Carcinoma | MTOR Activating Mutation

United States
Ultragenyx Pharmaceutical Inc

Terminated

Study to Evaluate the Safety and Efficacy of Aceneuramic Acid Extended-Release (Ace-ER) Tablets in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myopathy (HIBM)

Hereditary Inclusion Body Myopathy | GNE Myopathy | Distal Myopathy With Rimmed Vacuoles | Distal Myopathy, Nonaka Type | Quadriceps Sparing Myopathy

United States, Canada, United Kingdom, Israel, Italy, Bulgaria, France
Ultragenyx Pharmaceutical Inc
Newcastle University

Completed

GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

Hereditary Inclusion Body Myopathy | GNE Myopathy | Nonaka Disease | Quadriceps Sparing Myopathy (QSM) | Distal Myopathy With Rimmed Vacuoles (DMRV)

United States, Bulgaria, Canada, France, United Kingdom
UNICANCER
Institut National de la Santé Et de la Recherche Médicale, France; Gustave... and other collaborators

Recruiting

Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes. (TUMOSPEC)

Mutation | Hereditary Breast and Ovarian Cancer

France
Nobelpharma

Completed

Efficacy Confirmation Study of NPC-09

GNE Myopathy | Nonaka Disease | Distal Myopathy With Rimmed Vacuoles (DMRV) | Hereditary Inclusion Body Myopathy (hIBM)

Japan
University of Washington
Department of Health and Human Services

Recruiting

Telehealth Pain Self-Management for Employed Adults (E-TIPS)

Multiple Sclerosis | Chronic Pain | Brain Injuries, Traumatic | Amputation | Spinal Cord Injuries

United States
Michael Boninger
Northwestern University; University of Chicago; Carnegie Mellon University

Recruiting

Cortical Recording and Stimulating Array Brain-Machine Interface (CRS-BMI)

Spinal Cord Injury | Tetraplegia | Brachial Plexus Injury | Brainstem Stroke | Above Elbow Amputation

United States
Nationwide Children's Hospital

Active, not recruiting

Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care (SSTIBE)

Abscess | Cellulitis | Drain Abscess | Behavioral Economics | Impetigo | Skin Infection | Antibiotic Duration

United States
Ultragenyx Pharmaceutical Inc

Terminated

A Study to Evaluate the Safety of Aceneuramic Acid Extended Release (Ace-ER; UX001) Tablets in Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy (GNEM) (Also Known as Hereditary Inclusion Body Myopathy [HIBM]) Patients With Severe Ambulatory Impairment

Hereditary Inclusion Body Myopathy | GNE Myopathy | Inclusion Body Myopathy 2 | Distal Myopathy With Rimmed Vacuoles | Distal Myopathy, Nonaka Type | Quadriceps Sparing Myopathy

Canada, United States, Bulgaria
Azienda Ospedaliero-Universitaria di Modena
University of Modena and Reggio Emilia

Not yet recruiting

Effectiveness of the Autologous Adipose Tissue Harvested With SEFFICARE Method for Treatment of DFU Minor Amputation (SEFFIDiFA)

Diabetic Foot | Amputation | Diabetic Foot Ulcer

Italy
General Hospital of Ningxia Medical University

Unknown

The Clinical Research on the Relationship Between Circadian Rhythm and Gut Microbiota in TBI Patients

Traumatic Brain Injury | Loss of Consciousness of Unspecified Duration | Cerebral Laceration and Contusion

China
Yonsei University

Completed

Comparison of Anesthetic Modalities on Hemodynamic Stability and Postoperative Pain in Diabetic Foot Patients Undergoing Minor Lower Extremity Amputation

Diabetic Foot Ulcer | Lower Extremity Amputation
Shanghai EpimAb Biotherapeutics Co., Ltd.
Labcorp Corporation of America Holdings, Inc

Not yet recruiting

EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Advanced Lung Non-Small Cell Carcinoma | EGFR Mutation-Related Tumors

United States, China
University of Alabama at Birmingham
National Institutes of Health (NIH); Mereo BioPharma

Completed

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)

Emphysema or COPD | Alpha-1 Antitrypsin Deficiency (AATD) | Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations

United States
Queen Mary University of London
AstraZeneca; Cancer Research UK

Unknown

A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers (TORCMEK)

Squamous Cell Lung Cancer | Triple-Negative Breast Cancer | Non-squamous Cell Lung Cancer With KRAS Mutations | Non-squamous Cell Lung Cancer With Wild-type KRAS

United Kingdom
Rigel Pharmaceuticals
Nationwide Children's Hospital

Not yet recruiting

Study of Olutasidenib and Temozolomide in HGG

Astrocytoma | High Grade Glioma | Oligodendroglioma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | Spinal Tumor | Astrocytoma, Grade III | Astrocytoma, Grade IV | IDH1 Mutation | WHO Grade IV Glioma | Thalamus Tumor | IDH1 R132 | IDH1 R132C | IDH1 R132H and other conditions

United States, Australia, United Kingdom, Canada, Germany, Netherlands
University of Wisconsin, Madison
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Enrolling by invitation

Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers

Diabetic Foot | Amputation | Diabetic Ulcer of Left Foot | Diabetic Ulcer of Right Foot

United States
Bolan Medical Complex Hospital Quetta Pakistan

Completed

Predictors of Foot Amputation in Diabetic Foot Ulcers

Diabetic Foot | Amputation | Diabetic Foot Ulcer | Antibiotic Resistant Strain

Pakistan
McMaster University
Canadian Institutes of Health Research (CIHR); Technology Evaluation in the... and other collaborators

Completed

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial (PROSPECT)

Antibiotic-Associated Diarrhea | Ventilator Associated Pneumonia (VAP) | Other Infections | C-Difficile | Duration of Mechanical Ventilation | Length of ICU Stay | Length of Hospital Stay | ICU and Hospital Mortality

United States, Canada
NYU Langone Health
American Heart Association

Completed

Platelet Activity in Vascular Surgery for Thrombosis and Bleeding (PIVOTAL)

Embolism and Thrombosis | Carotid Stenosis | Peripheral Vascular Disease | Peripheral Artery Disease | Aortic Aneurysm, Abdominal | Aortic Aneurysm | Aortic Aneurysm, Thoracic | Amputation, Wound

United States
Defense and Veterans Center for Integrative Pain...

Completed

Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain

Analgesia | Pain, Acute | Post Traumatic Stress Disorder | Amputation, Traumatic | Trauma, Brain

United States
Chinese University of Hong Kong

Completed

Herbal Preparation Used as Adjuvant Therapy on Diabetic Ulcers

Amputation | Diabetic Foot Ulcer

China
Washington University School of Medicine
Association of Frontotemporal Degeneration; Tau Consortium

Completed

Human CNS Tau Kinetics in Tauopathies (TANGLES)

Progressive Supranuclear Palsy (PSP) | Corticobasal Degeneration (CBD) | Frontotemporal Dementia (FTD MAPT Mutation)

United States
Washington University School of Medicine

Completed

A Wheelchair Propulsion Training Program (HS)

Multiple Sclerosis | Amputation | Spinal Cord Injuries | Spina Bifida

United States
QuantumLeap Healthcare Collaborative

Recruiting

PRE-I-SPY Phase I/Ib Oncology Platform Program (PRE-I-SPY-PI)

Solid Tumor | Metastatic Cancer | Metastatic Breast Cancer | Triple Negative Breast Cancer | HER2-positive Breast Cancer | Solid Tumor, Adult | Solid Carcinoma | HER2-positive Metastatic Breast Cancer | Progesterone Receptor-positive Breast Cancer | HER2-negative Breast Cancer | Estrogen Receptor Positive... and other conditions

United States
University of California, San Diego
New York University; Heinrich-Heine University, Duesseldorf; Universität Tübingen

Recruiting

Natural History Study of Patients With HPDL Mutations

Genetic Disease | Mitochondrial Encephalomyopathies | Neonatal Encephalopathy | Mutation | Hereditary Spastic Paraplegia | White Matter Disease | Spastic Paraplegia

United States
Istituto Auxologico Italiano

Recruiting

Efficacy of Split Gait in the Treatment of Dynamic Asymmetries in Subjects With Pathologic Claudication (ESPLICA)

Multiple Sclerosis | Parkinson Disease | Amputation | Poststroke/CVA Hemiparesis | Knee Impairment

Italy
Black Diamond Therapeutics, Inc.

Recruiting

Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Non-Small Cell Lung Cancer | NSCLC | Metastatic Lung Cancer | Metastatic Lung Non-Small Cell Carcinoma | EGF-R Positive Non-Small Cell Lung Cancer | Advanced Lung Carcinoma | EGFR-TKI Resistant Mutation | Advanced Non-Small Cell Squamous Lung Cancer | Epidermal Growth Factor Receptor C797S | Epidermal...

United States
Roswell Park Cancer Institute

Active, not recruiting

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

Acute Myeloid Leukemia | Polycythemia Vera | Myelofibrosis | Chronic Myelomonocytic Leukemia | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Sickle Cell Disease | Myelodysplastic Syndrome | Plasma Cell Myeloma | Chronic Granulomatous... and other conditions

United States
University of California, San Francisco

Terminated

BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES (TauBasket)

Nonfluent Aphasia, Progressive | Primary Tauopathies | Corticobasal Degeneration Syndrome | Frontotemporal Lobar Degeneration With Tau Inclusions | MAPT Mutation Carriers, Symptomatic | Traumatic Encephalopathy Syndrome

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Personalized NK Cell Therapy in CBT

Recurrent Hodgkin Lymphoma | Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Myelodysplastic Syndrome... and other conditions

United States
Fujian Cancer Hospital

Not yet recruiting

the Efficacy and Safety of Dalpiciclib Combined With Third-generation EGFR-TKI in Patients With EGFR Mutation and Meningial Metastasis in Non-small Cell Lung Cancer Progressing Through Third-generation TKI and Platinum-containing Two-drug Chemotherapy

Non-small Cell Lung Cancer Confirmed by Histopathology or Cytology | The TNM (8th) Phase is IV | With EGFR Mutations | Meningeal Progression Occurred After Previous Platinum-containing Two-drug Chemotherapy and Third-generation EGFR-TKI Treatment | Male or Female | The Age of 18 Years Old or... and other conditions
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Completed

The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients

Diabetic Foot | Amputation | Valve Heart Disease | Valve Disease, Aortic
University College Hospital Galway

Recruiting

MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation (MetaMet)

Diabetic Foot | Amputation | Wound Infection | Wound Complication | Wound Healing Delayed | Critical Limb-Threatening Ischaemia | Gangrene; Limb

Ireland
Baylor College of Medicine
Electrochemical Oxygen Concepts, Inc.

Recruiting

EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds

Diabetes | Diabetic Foot | Breast Cancer | Peripheral Arterial Disease | Surgical Wound | Amputation Wound | Incision Wound

United States
Forma Therapeutics, Inc.

Completed

A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 Mutation

Cohort 1a and 1b: Glioma (Advanced Gliomas and Glioblastoma Multiforme) | Cohort 2a and 2b: Hepatobiliary Tumors (Hepatocellular Carcinoma, Bile Duct Carcinoma, Intrahepatic Cholangiocarcinoma, Other Hepatobiliary Carcinomas) | Cohort 3a and 3b: Chondrosarcoma | Cohort 4a and 4b: Intrahepatic... and other conditions

United States, Korea, Republic of, Australia, United Kingdom, Spain, France
King Saud University

Completed

Novel Gentic Variations Contributing to Asthma Susceptability in Saudi Arabia

Collection of Clinical Data That Will be Used in This Study and Will Form a Data Bank for Asthma in Saudi Arabia | Identify Known and NOVEL Genetic Risk Factors Contributing to Asthma Susceptibility | Study the Mechanistic Roles of the Genetic Variants Within Major Asthma Susceptibility...

Saudi Arabia
Istituto Auxologico Italiano

Recruiting

Mechanical Determinants of Upper Limbs Oscillation During Gait (CLAPENDAS)

Multiple Sclerosis | Cerebral Palsy | Parkinson Disease | Amputation | Poststroke/CVA Hemiparesis

Italy
Hvidovre University Hospital
Roskilde University

Recruiting

Time to Heal (Wound, Healing, Dialogue, Nutrition) (SNAK)

Leg Ulcer | Venous Leg Ulcer | Foot Ulcer, Diabetic | Amputation Stump | Arterial Leg Ulcer

Denmark
McGill University

Not yet recruiting

Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.

Cerebral Palsy | Amputation | Spinal Cord Injuries | Spina Bifida | Musculoskeletal Disorder | Juvenile Arthritis

Canada

Clinical Trials on BRCA1 Gene Mutation

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Medical Conditions

Drug Interventions

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CROs in Jamaica

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Rare Diseases

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