Clinical Trials on Beta-Amyloid

Total 4515 results

Centre Hospitalier de Valenciennes
University Hospital, Lille; Centre Hospitalier de Bethune; Centre Hospitalier... and other collaborators

Recruiting

Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study (BLIPIC)

Pneumonia | Continuous Renal Replacement Therapy | Antibiotic | Beta-lactam

France
Assistance Publique Hopitaux De Marseille

Completed

Expanding the Biomarkers in Familial Amyloid Neuropathy: MRI and Motor Unit Estimation by Electrophysiological Study

Amyloid Neuropathies | Transthyretin Amyloidosis

France
Nantes University Hospital
Pfizer

Completed

Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology (PRE-TRANS)

Transthyretin Amyloidosis | Familial Amyloid Neuropathy

France
Seoul National University Bundang Hospital
Samsung Medical Center; Wonju Severance Christian Hospital

Recruiting

Carvedilol in HF With Preserved EF

Heart Failure With Preserved Ejection Fraction | Myocardial Strain | Beta Blocker

Korea, Republic of
Ionis Pharmaceuticals, Inc.

Completed

Extension Study Assessing Long Term Safety and Efficacy of IONIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP)

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
Ionis Pharmaceuticals, Inc.

Completed

Efficacy and Safety of Inotersen in Familial Amyloid Polyneuropathy

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

New Zealand, United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
University of Trieste
Pfizer

Unknown

Unmasking the Prevalence of AC in an Unselected Echocardiographic Population (AC-TIVE)

Amyloid Cardiomyopathy

Italy
Pfizer

Active, not recruiting

A Study to Learn About the Study Medicine Called Tafamidis 61mg in People Diagnosed With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy

Korea, Republic of
Pfizer

Completed

A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy

China
AstraZeneca

Recruiting

EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy (EPIC-ATTR)

Transthyretin Amyloid Cardiomyopathy

China
Pfizer

Recruiting

A Study to Learn About Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in India

Transthyretin Amyloid Cardiomyopathy

India
Brigham and Women's Hospital

Not yet recruiting

ION-682884 in Patients With TTR Amyloid Cardiomyopathy

Transthyretin Amyloid Cardiopathy

United States
Columbia University

Completed

SGLT2 Inhibitors in Transthyretin Amyloid Cardiomyopathy

Transthyretin Amyloid Cardiomyopathy

United States
Centre Hospitalier Universitaire de Besancon

Unknown

Impact of Number of Rank of B-lactam Antibiotics on Emergence on Multidrug Resistant Bacteria (INOR Blact)

Antibiotic Resistant Infection | Resistant Infection | Beta Lactam Resistant Bacterial Infection | Bacterial Resistance
Alexion Pharmaceuticals, Inc.

Recruiting

Study of ALXN2220 Versus Placebo in Adults With ATTR-CM (DepleTTR-CM)

Transthyretin Amyloid Cardiomyopathy

United States, Spain, United Kingdom, Norway, Israel, China, Korea, Republic of, Belgium, France, Germany, Italy, Japan, Australia, Argentina, Austria, Taiwan, Switzerland, Canada, Sweden, Poland, Denmark, Turkey, Brazil, Netherlands, G... and more
Neurimmune AG

Completed

First-in-Human Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy

Amyloid Transthyretin Cardiomyopathy

Germany, France, Netherlands, Spain
Boston University
National Institute of Neurological Disorders and Stroke (NINDS); Food and Drug...

Completed

The Effect of Diflunisal on Familial Amyloidosis

Familial Amyloid Polyneuropathy | Familial Amyloidosis

United States, Italy, Japan, Sweden, United Kingdom
Pfizer

Recruiting

Vyndaqel Capsules Special Investigation (ATTR-CM)

Transthyretin (TTR) Amyloid Cardiomyopathy

Japan
Nantes University Hospital

Completed

The Association Between Advancing Age and Mortality at 30 Days in Patients With Bacteremia E. Coli Beta-lactamase Phenotype Extended Spectrum RC15_0421 (MoBaCo)

Beta-lactamase Extended Spectrum, E. Coli, Elderly, Mortality, Risk Factor

France
Alexion Pharmaceuticals, Inc.
Eidos Therapeutics, a BridgeBio company

Active, not recruiting

A Phase 3 Study of ALXN2060 in Japanese Participants With Symptomatic ATTR-CM

Symptomatic Transthyretin Amyloid Cardiomyopathy

Japan
Eidos Therapeutics, a BridgeBio company

Active, not recruiting

Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants

Amyloid Cardiomyopathy, Transthyretin-Related

United States, Spain, Australia, Canada, Italy, Netherlands, Ireland, New Zealand, Belgium, Israel, Greece, Korea, Republic of, Czechia, Brazil, Denmark, Portugal, United Kingdom
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University; DSM Nutritional Products, Inc.

Completed

Effect of SNPs in the BCMO1 Enzyme (BETASNP2)

Vitamin A Deficiency | Beta-carotene Bioavailability

United Kingdom
Hospital de Mataró

Unknown

The Effect of Beta-blockers in Substance P Levels and the Swallowing Function (BETASP)

Swallowing Disorder | Beta Blockers | Substance P

Spain
National Institute of Allergy and Infectious Diseases...

Completed

Prevention of GBS Colonization Via Immunity

Beta Haemolytic Streptococcal Infection

United States
Pfizer

Recruiting

Korean Post-marketing Surveillance Vyndamax® Capsules for the Treatment of Transthyretin Amyloid Cardiomyopathy

ATTR-CM (Transthyretin Amyloid Cardiomyopathy)

Korea, Republic of
Novo Nordisk A/S

Active, not recruiting

A Research Study to Look at How a New Medicine Called NNC6019-0001 Works and How Safe it is for People Who Have Heart Disease Due to Transthyretin (TTR) Amyloidosis

Transthyretin Amyloid Cardiomyopathy (ATTR CM)

United States, Netherlands, Spain, Portugal, Canada, Czechia, France, Germany, Italy, Japan
Alnylam Pharmaceuticals

Approved for marketing

Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

Amyloid Neuropathies | Amyloid Neuropathies, Familial | TTR-mediated Amyloidosis | Amyloidosis, Hereditary | Amyloidosis, Hereditary, Transthyretin-Related | Familial Amyloid Polyneuropathies
Mahidol University
Pfizer

Not yet recruiting

Thailand ATTR-CM Registry

Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Thailand
Alnylam Pharmaceuticals

Completed

APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis

Amyloid Neuropathies | Amyloid Neuropathies, Familial | TTR-mediated Amyloidosis | Amyloidosis, Hereditary | Amyloidosis, Hereditary, Transthyretin-Related | Familial Amyloid Polyneuropathies

United States, Canada, Argentina, Australia, Bulgaria, Cyprus, Italy, Japan, Malaysia, Mexico, Netherlands, Portugal, Spain, Sweden, Germany, France, Brazil, Turkey, Korea, Republic of, Taiwan, United Kingdom
VA Greater Los Angeles Healthcare System
AstraZeneca

Completed

Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD

Pulmonary Disease, Chronic Obstructive | Asthma | Adverse Effect of Beta-adrenoreceptor Antagonists

United States
New York Medical College

Completed

CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant

Lymphoma | Leukemia | Sickle Cell Disease | Histiocytosis | Immunodeficiencies | Inborn Errors of Metabolism | Bone Marrow Failure | Beta Thalassemia

United States
Medical University of Graz
Medical University Innsbruck

Recruiting

Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Amyloid Cardiomyopathy | Wild Type ATTR Amyloidosis

Austria
Ionis Pharmaceuticals, Inc.
AstraZeneca

Recruiting

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Austria, Belgium, Canada, France, Germany, Israel, Italy, Portugal, Spain, Sweden, United Kingdom, Australia, Greece
Central Hospital, Nancy, France

Recruiting

Assessment of 18F-Florbetaben Whole-body PET for the Detection of Cardiac and Extracardiac Sites of Amyloid Deposits (CAPRI)

Cardiac Amyloidosis

France
Ionis Pharmaceuticals, Inc.

Active, not recruiting

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Australia, Spain, Canada, Germany, Japan, Italy, Israel, Argentina, France, Portugal, Austria, Brazil, Greece, United Kingdom, Czechia, Sweden, Belgium, Denmark, Poland, Puerto Rico
Algalarrondo Vincent
Bichat Hospital; Bioquantis

Recruiting

Artificial Intelligence to Assist the Echocardiographic Identification of Transthyretin Cardiac Amyloidosis (AI-ATTR-ECHO)

Transthyretin Cardiac Amyloidosis | Transthyretin Amyloid Cardiomyopathy | Amyloid Cardiomyopathy

France
Novo Nordisk A/S

Recruiting

A Research Study to Look at Long-term Treatment With a Medicine Called NNC6019-0001 for People Who Have Heart Failure Due to Transthyretin Amyloidosis

Transthyretin Amyloid Cardiomyopathy (ATTR CM)

United States, Netherlands, Germany, Canada, Czechia, France, Italy, Portugal, Spain
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Severe Group A Streptococcus Infections in Paris, France, 2018-2023 (IGASI)

Invasive Group A Beta-Haemolytic Streptococcal Disease

France
University Health Network, Toronto

Completed

Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion

Insulin Resistance Syndrome X | Pancreatic Beta Cell Function

Canada
Alnylam Pharmaceuticals

Completed

The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant

ATTR Amyloidosis | Transthyretin (TTR)-Mediated Amyloidosis | Familial Amyloidotic Polyneuropathy (FAP) | Familial Amyloid Neuropathies

France, Germany, Portugal, United Kingdom, Sweden, Spain
Greenwood Genetic Center

Completed

Longitudinal Studies of the Glycoproteinoses

Galactosialidosis | Sialidosis | Fucosidosis | Aspartylglucosaminuria | Alpha Mannosidosis | Beta Mannosidosis | Mucolipidosis II | Mucolipidosis III | Schindler Disease

United States
University Hospital, Basel, Switzerland
Gebert Rüf-Stiftung

Active, not recruiting

Developing Microbials to Fight Extended-spectrum Beta-lactamase (ESBL)-Producing Escherichia Coli

Extended Spectrum Beta Lactamases (ESBL) E. Coli

Switzerland
The Netherlands Cancer Institute
Eli Lilly and Company; Universitaire Ziekenhuizen KU Leuven; European Organisation... and other collaborators

Withdrawn

Galunisertib and Capecitabine in Advanced Resistant TGF-beta Activated Colorectal Cancer (EORTC1615)

Colorectal Cancer Metastatic

Netherlands
The Netherlands Cancer Institute
Eli Lilly and Company; Universitaire Ziekenhuizen KU Leuven; European Organisation... and other collaborators

Unknown

LY3200882 and Capecitabine in Advanced Resistant TGF-beta Activated Colorectal Cancer (EORTC1615)

Colorectal Cancer Metastatic
University Hospital, Bordeaux
University of Bordeaux

Completed

Early and Systematic Screening in Chronic Neuropathy (TTR-FAP)

Amyloid Neuropathies, Familial

France
Assiut University

Not yet recruiting

Study on the Effect of Different Risk Factors on the Growth Parameters of Thalassemic Patients in Assiut (AUCH)

Thalassemia Major
Università degli Studi di Ferrara

Completed

Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients

Thalassemia Major

Italy
HaEmek Medical Center, Israel

Completed

Endocrine and Nutritional Assessment in B Thalassemia Major

Thalassemia

Israel
Cerus Corporation

Completed

Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion

Thalassemia Major

Turkey, Italy
Medical College of Wisconsin

Recruiting

Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

United States

Clinical Trials on Beta-Amyloid

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