Clinical Trials on Bone Sarcomas

Total 28136 results

Merck Sharp & Dohme LLC
Ariad Pharmaceuticals

Completed

Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) (SUCCEED)

Metastatic Soft-Tissue Sarcomas | Metastatic Bone Sarcomas
Asan Medical Center
Novartis

Completed

RAD001 in Advanced Sarcoma

Soft Tissue Sarcomas | Bone Sarcomas

Korea, Republic of
Grupo Espanol de Investigacion en Sarcomas

Recruiting

Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas (SYNERGIAS)

Soft Tissue Sarcoma | Bone Tumors | Small Round-cell Sarcomas

Spain
UNICANCER

Recruiting

A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE)

Chondrosarcomas | Ewing Sarcomas | Osteosarcomas | Chondroma | CIC-Rearranged Sarcoma

France
Grupo Espanol de Investigacion en Sarcomas

Recruiting

Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination With Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor (PRIME)

Advanced Solid Tumor | Advanced Soft-tissue Sarcoma | Advanced L-sarcomas | Other Advanced Sarcomas | Localized Soft-tissue Sarcoma

Spain
St. Jude Children's Research Hospital

Withdrawn

Markers of Anthracycline-Related Cardiac Muscle Injury

Osteosarcoma | Rhabdomyosarcoma | Ewing's Sarcoma Family of Tumors | Non-rhabdomyosarcoma Soft Tissue Sarcomas
David Dickens

Withdrawn

Gemcitabine With Ascorbate Including Adolescents

Soft Tissue Sarcoma | Bone Sarcoma | Unresectable Soft Tissue Sarcoma | Metastatic Soft-tissue Sarcoma | Metastatic Bone Sarcoma | Unresectable Bone Sarcoma

United States
Memorial Sloan Kettering Cancer Center

Recruiting

Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas

Osteosarcoma | Chondrosarcoma | Bone Neoplasm | Bone Sarcoma | Ewing's Sarcoma | Osseous Sarcoma

United States
Tata Memorial Hospital
Terry Fox Foundation

Completed

An Adequate Cost Effective Follow Up Protocol For Bone and Soft Tissue Sarcomas (TOSS)

Sarcomas

India
Institut Bergonié
PharmaMar

Completed

Targeting Microenvironment and Cellular Immunity in Sarcomas Weekly Trabectedin Combined With Metronomic Cyclophosphamide (TARMIC)

Soft-tissue Sarcomas

France
Henan Cancer Hospital

Completed

Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule

Soft Tissue Sarcomas

China
University of Florida

Withdrawn

Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas (SA02)

Soft Tissue Sarcomas
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas

Soft Tissue Sarcoma

United States
Institute of Mother and Child, Warsaw, Poland
Maria Sklodowska-Curie National Research Institute of Oncology

Recruiting

Regorafenib in Patients With Refractory Primary Bone Tumors (Regbone)

Osteosarcoma | Ewing Sarcoma of Bone

Poland
National Cancer Institute (NCI)

Completed

Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery

Stage III Soft Tissue Sarcoma AJCC v7 | Stage IV Soft Tissue Sarcoma AJCC v7 | Pleomorphic Liposarcoma | Metastatic Undifferentiated Pleomorphic Sarcoma | Metastatic Unresectable Sarcoma | Unresectable Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma | Locally Advanced Soft Tissue Sarcoma | Metastatic... and other conditions

United States
Vanderbilt-Ingram Cancer Center

Recruiting

Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

Soft Tissue Sarcomas

United States
Institut Bergonié
Ministry of Health, France; National Cancer Institute, France

Recruiting

CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study. (NEOSarcomics)

Soft-tissue Sarcomas

France
NYU Langone Health
Bristol-Myers Squibb

Withdrawn

Study of Nivolumab With or Without Pazopanib in Metastatic or Unresectable Soft Tissue Sarcomas

Soft Tissue Sarcomas

United States
The Netherlands Cancer Institute
Leiden University Medical Center

Recruiting

Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas (SCOPES)

Soft Tissue Sarcomas

Netherlands
Stanford University
Amgen

Terminated

Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

Bone Cancer | Ewing's Sarcoma

United States
Heike E Daldrup-Link

Completed

Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI (Osteosarcoma)

Bone Cancer | Osteosarcoma | Chondrosarcoma | Rhabdomyosarcoma | Bone Sarcoma | Osteomyelitis | Bone Necrosis | Ewing's Sarcoma

United States
National Cancer Institute (NCI)

Completed

Cabozantinib for Adults With Advanced Soft Tissue Sarcoma

Refractory Soft Tissue Sarcomas

United States
Mohammed Milhem, MBBS
University of Iowa; University of Iowa Adolescent and Young Adult (AYA) Cancer... and other collaborators

Terminated

Gemcitabine Plus Ascorbate for Sarcoma in Adults

Sarcoma | Soft Tissue Sarcoma | Bone Sarcoma | Metastatic Bone Tumor | Unresectable Soft Tissue Sarcoma

United States
Mohammed Milhem, MBBS
University of Iowa

Recruiting

Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

Sarcoma | Soft Tissue Sarcoma | Bone Sarcoma | Metastatic Bone Tumor | Unresectable Soft Tissue Sarcoma

United States
National Cancer Institute (NCI)

Completed

Blood and Tissue Study of Patients in NIH Protocol 08-C-0800

Sarcomas

United States
Balgrist University Hospital

Terminated

Identification and Characterization of Molecular Markers in Musculoskeletal Tumors

Sarcoma | Soft Tissue Sarcoma | Sarcoma of Bone | Soft Tissue and Bone Tumors

Switzerland
Mayo Clinic

Recruiting

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

Ewing Sarcoma of Bone | Chondrosarcoma | Chordoma | Bone Sarcoma | Pelvic Rhabdomyosarcoma

United States
Onxeo
Spectrum Pharmaceuticals, Inc

Completed

A Phase I/II Clinical Trial of PXD101 in Combination With Doxorubicin in Patients With Soft Tissue Sarcomas

Dose Escalation: Solid Tumors | MTD: Soft Tissue Sarcomas

Denmark, United Kingdom
Balgrist University Hospital
University of Bern

Terminated

National Swiss Sarcoma Cohort Study (SwissSARCOS)

Sarcoma | Neoplasms | Soft Tissue Sarcoma | Neoplasm of Bone | Soft Tissue Neoplasm | Sarcoma of Bone

Switzerland
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery

Bone Cancer | Chondrosarcoma | Recurrent Osteosarcoma | Clear Cell Sarcoma of the Kidney | Metastatic Osteosarcoma | Ovarian Sarcoma | Recurrent Adult Soft Tissue Sarcoma | Recurrent Uterine Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage III Uterine Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Stage...

United States
Gustave Roussy, Cancer Campus, Grand Paris
Bayer

Recruiting

Phase Ib / Regorafenib With Conventional Chemotherapy/Newly Diagnosed Patients/ Multimetastatic Ewing Sarcoma (REGO-EWING)

Bone Cancer

France
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

Long Term Brain Toxicity of Chemotherapy in Patients Treated for a Bone TumorDuring Childhood or Adolescence (OSE)

Adults Treated During Childhood or Adolescence for a Malignant Bone Tumor (Osteosarcoma and Ewing Sarcoma)

France
M.D. Anderson Cancer Center
Aadi Bioscience

Not yet recruiting

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Leiomyosarcoma | Soft-tissue Sarcomas

United States
Brown University
Actuate Therapeutics Inc.

Withdrawn

Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma

Soft Tissue Sarcoma | Osteosarcoma | Ewing Sarcoma of Bone | Leiomyosarcoma | High Grade Sarcoma | Liposarcoma | Rhabdomyosarcoma | Angiosarcoma | Bone Sarcoma | Synovial Sarcoma | Undifferentiated Pleomorphic Sarcoma | Myxofibrosarcoma | Spindle Cell Sarcoma

United States
Istituto Ortopedico Rizzoli

Recruiting

Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery (ADER)

Osteosarcoma | Ewing Sarcoma | Chondrosarcoma | Bone Tumor

Italy
University of Southern California
National Cancer Institute (NCI)

Completed

Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma

Bone Sarcoma | Retroperitoneal Sarcoma | Adult Soft Tissue Sarcoma

United States
Italian Sarcoma Group
AstraZeneca; PharmaMar; Istituto Di Ricerche Farmacologiche Mario Negri

Completed

Trabectedin Plus Olaparib in Metastatic or Advanced Sarcomas (TOMAS) (TOMAS)

Soft Tissue Sarcoma | Bone Tumor

Italy
HMeany

Completed

Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients With Solid Tumors

Osteosarcoma | Neuroblastoma | Brain Tumors | Ewing's Sarcoma Family of Tumors | Rhabdomyosarcoma and Other Soft Tissue Sarcomas

United States
Italian Sarcoma Group

Recruiting

Observational Study on Skeletal Ewing's Sarcoma (EWOss)

Ewing Sarcoma of Bone

Italy
University College, London
Cancer Research UK; NCRI Radiotherapy Trials QA (RTTQA) Group

Completed

A Study of IMRT in Primary Bone and Soft Tissue Sarcoma (IMRiS)

Ewing Sarcoma | Chordoma | Bone Sarcoma | Soft Tissue Sarcoma, Adult

United Kingdom, Ireland
Case Comprehensive Cancer Center

Recruiting

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Relapsed Sarcomas

United States
Blokhin's Russian Cancer Research Center

Recruiting

3D Printed Implants for the Defect Reconstruction in Patients With Chest Wall Tumors

Surgery | Implant Site Reaction | Sarcoma of Bone | Chest Wall Tumor | Tumor of Bone | Chest Wall Sarcoma

Russian Federation
Nantes University Hospital

Completed

Cost-effectiveness Evaluation of the Use of a Patient Specific Instrument for Surgical Resection of Malignant Bone Tumor Within the Pelvis Versus the Conventional Surgical Treatment (MARGIC)

Sarcoma, Bone Tumor

France
M.D. Anderson Cancer Center

Recruiting

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

Soft Tissue Sarcoma | Bone Sarcoma

United States
Grupo Espanol de Investigacion en Sarcomas

Recruiting

Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas (ImmunoSarc)

Soft Tissue Sarcoma | Bone Sarcoma

Spain, United Kingdom, Italy
Macarena De La Fuente, MD

Active, not recruiting

Dendritic Cell Vaccine for Children and Adults With Sarcoma

Sarcoma | Soft Tissue Sarcoma | Bone Sarcoma

United States
Sun Yat-sen University
Guangdong Xiangxue Precision Medical Technology Co., Ltd.

Active, not recruiting

NY-ESO-1-specific T Cell Receptor (TCR) T Cell in Sarcoma

Soft Tissue Sarcoma | Bone Sarcoma

China
Centre Leon Berard
Ministry of Health, France

Completed

Study of Continuous Dosing of Sunitinib in Non GIST Sarcomas With Concomitant Radiotherapy

Non GIST Sarcomas

France
The Netherlands Cancer Institute
Royal Marsden NHS Foundation Trust

Terminated

Clinical Study of Concurrent Pazopanib and Radiotherapy for Non-metastatic Sarcoma Patients (PASART-2)

Sarcoma | Soft Tissue Sarcomas

United Kingdom, Netherlands
Sarcoma Alliance for Research through Collaboration
Merck Sharp & Dohme LLC

Completed

SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas

Soft Tissue Sarcoma | Bone Sarcoma

United States

Clinical Trials on Bone Sarcomas

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