Clinical Trials on Central Nervous System Disease

Total 293846 results

Bristol-Myers Squibb

Completed

Efficacy Study of Ipilimumab Versus Placebo to Prevent Recurrence After Complete Resection of High Risk Stage III Melanoma

High Risk Stage III Melanoma

Italy, Poland, United Kingdom, United States, Netherlands, Spain, Australia, France, Germany, Canada, Russian Federation, Belgium, Norway, Switzerland, Sweden, Finland, Austria, Denmark, Czechia
National Cheng-Kung University Hospital
National Cheng Kung University; National Research Program for Biopharmaceuticals... and other collaborators

Unknown

Taiwan ACE Beads for Embolization Therapy in Symptomatic Benign Prostatic Hyperplasia

Lower Urinary Tract Symptom | Benign Prostatic Hyperplasia (BPH)

Taiwan
Lund University Hospital

Completed

A Multicenter Study Evaluating Efficacy and Safety of 177Lu-DOTA-TATE Based on Kidney-Dosimetry in Patients With Disseminated Neuroendocrine Tumors (ILUMINET)

Neuroendocrine Tumors | Liver Metastases

Sweden
Shanghai First Maternity and Infant Hospital

Unknown

Programmed Death-1(PD-1) Inhibitor Combined With Progesterone Treatment in Endometrial Cancer (ECCT)

Endometrial Cancer Stage I
Carolina Research Professionals, LLC
Astellas Pharma Inc

Completed

Open Label Phase Two Study of Enzalutamide With Concurrent Administration of Radium Ra 223 Dichloride in Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Symptomatic Bone Metastasis

Prostate Carcinoma Metastatic to the Bone

United States
Constantinos Hadjipanayis
Massachusetts General Hospital

Completed

5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor

Malignant Gliomas

United States
Bart Neyns
Pfizer

Completed

A Randomized Phase II Clinical Trial on the Efficacy of Axitinib as a Monotherapy or in Combination With Lomustine for the Treatment of Patients With Recurrent Glioblastoma (AxiGII)

Glioblastoma Multiforme

Belgium
Ipsen

Completed

Study to Evaluate the Presence of Lower Urinary Tract Symptoms (LUTS) in Prostate Cancer Patients Scheduled to Receive Luteinizing Hormone Releasing Hormone (LHRH) Analogues (ANALUTS)

Prostate Cancer

Spain, Portugal
Institut Cancerologie de l'Ouest

Terminated

Comparing Palliative Radiotherapy With or Without Carboplatin (METAXIOM)

Head and Neck Cancer | Lung Cancer | Metastatic Cancer

France
Dana-Farber Cancer Institute
Novartis; Pediatric Oncology Experimental Therapeutics Investigators' Consortium

Completed

Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas

Glioma | Astrocytoma | Low-grade Glioma

United States
Precision Life Sciences Group

Completed

A Study of ICT-121 Dendritic Cell Vaccine in Recurrent Glioblastoma

Glioblastoma Multiforme

United States
Cairo University

Unknown

Recurrence in Buccinator Muscle Excision With the Skin Versus Without the Skin in Buccal Squamous Cell Carcinoma

Squamous Cell Carcinoma of the Oral Cavity
Weill Medical College of Cornell University

Unknown

Photodynamic Therapy (PDT) Cholangiocarcinoma Registry (PDTRegistry)

Biliary Stricture | Unresectable Cholangiocarcinoma | Biliary Obstruction | Stent Obstruction

United States
Albany Medical College

Unknown

Prophylactic Post-Cesarean Incisional Negative-pressure Wound Therapy in Morbidly Obese Patients

Morbid Obesity | Cesarean Section | Wound Infection | Negative-pressure Wound Therapy

United States
Genentech, Inc.

Completed

A Study of GDC-0084 in Patients With Progressive or Recurrent High-Grade Glioma

Glioblastoma, Glioma

United States, Spain
Song Lin

Unknown

Ketogenic Diet Adjunctive to Salvage Chemotherapy for Recurrent Glioblastoma:a Pilot Study (KGDinrGBM)

Glioblastoma Multiforme

China
Beijing Sanbo Brain Hospital
Marino Biotechnology Co., Ltd.

Unknown

Pilot Study of Autologous Anti-EGFRvIII CAR T Cells in Recurrent Glioblastoma Multiforme

Glioblastoma Multiforme

China
CytoVac A/S

Terminated

Randomized Phase 2 Study to Investigate Efficacy of ALECSAT in Patients With GBM Measured Compared to Avastin/Irinotecan

Glioblastoma Multiforme

Denmark
Shixuan Wang
Sun Yat-sen University; Huazhong University of Science and Technology; Shanghai... and other collaborators

Unknown

Cohort Study to Evaluate Ovarian Function

Cardiovascular Diseases | Menopausal Syndrome | Female Infertility Due to Diminished Ovarian Reserve | Sexual Function and Fertility Disorders

China
North Bristol NHS Trust

Withdrawn

Dose-Escalation Study of Carboplatin Administration Into the Brain for Glioblastoma Multiforme

Glioblastoma Multiforme

United Kingdom
National Cancer Institute (NCI)

Completed

Viral Therapy in Treating Patients With Metastatic Melanoma

Recurrent Melanoma | Stage IV Melanoma

United States
Far Eastern Memorial Hospital

Unknown

PET With Respiratory Gating Technique in Evaluation of Response and Normal Tissue Effect in Thoracic Cancer

To Correlate RPM Respiratory-gating Methods Analyses, Treatment Response, and Normal Tissue Metabolic Effect. | Application in Clinical Outcomes and Prediction of Prognosis.

Taiwan
Maastricht University Medical Center
Erasmus Medical Center; VieCuri Medical Centre

Unknown

Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate

Superficial Basal Cell Carcinoma

Netherlands
Leeds Cancer Centre at St. James's University Hospital

Unknown

Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma

Melanoma (Skin) | Hereditary Multiple Melanoma

United Kingdom
National Cancer Institute (NCI)

Completed

Interleukin-12 and Interferon Alfa in Treating Patients With Metastatic Malignant Melanoma

Recurrent Melanoma | Stage IV Melanoma

United States
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Patients With Metastatic Malignant Melanoma

Recurrent Melanoma | Stage IV Melanoma

United States
National Cancer Institute (NCI)

Completed

Vaccine Therapy and Sargramostim in Treating Patients With Stage IV Malignant Melanoma

Recurrent Melanoma | Stage IV Melanoma

United States
National Cancer Institute (NCI)

Terminated

SU5416 in Treating Patients With Metastatic Melanoma That Has Been Previously Treated

Recurrent Melanoma | Stage IV Melanoma

United States
Aga Khan University

Completed

Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants

Hemorrhage | Anemia | Complications | Jaundice | Ferritin

Pakistan
Alberta Health services
Amersham Health; The Prostate Cancer Research Foundation of Canada

Completed

A Trial of Strontium +/- Cisplatin for the Palliation of Bone Pain Secondary to Hormone Refractory Prostate Cancer

Bone Metastases | Hormone Refractory Prostate Cancer

Canada
Myrexis Inc.

Unknown

Phase 1 Study of MPC-6827 and Carboplatin in Recurrent/Relapsed Glioblastoma Multiforme

Glioblastoma Multiforme

United States
Medical University Innsbruck
Pfizer

Unknown

SUTENT (SUNITINIB, SU11248)in Patients With Recurrent or Progressive Glioblastoma Multiforme (SURGE01-07)

Glioblastoma Multiforme

Austria, Germany
Centro Universitário Augusto Motta

Enrolling by invitation

Use of the ADL-Glittre Test in the Pre and Postoperative Period of Patients With Lung Cancer

Quality of Life | Surgery | Physical Disability | Lung Cancer, Nonsmall Cell

Brazil
Shanghai University of Traditional Chinese Medicine
Shanghai Chest Hospital; Shanghai Cancer Hospital, China; Shanghai Pulmonary... and other collaborators

Unknown

Efficacy Study of Comprehensive Rehabilitation Program in Postoperative NSCLC Patients

Non-small Cell Lung Cancer

China
Memorial Sloan Kettering Cancer Center

Terminated

Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective Study in Individuals Diagnosed With Non-small Cell Lung Cancer Utilizing High-resolution Structural Magnetic Resonance Imaging

Non-small Cell Lung Cancer

United States
Centre Hospitalier Intercommunal Creteil

Not yet recruiting

Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout (Volem)

Ventilator-Induced Lung Injury | Medical Device | Extremely Low Birthweight Infant | Continuous Tracheal Gas Insufflation | Lung Protection
University of Massachusetts, Amherst
National Cancer Institute (NCI)

Recruiting

Fruit and Vegetable Intervention in Lactating Women to Reduce Breast Cancer Risk

Inflammation | Diet, Healthy | Risk Reduction | Breast Cancer Female | Postpartum Weight Retention

United States
ETOP IBCSG Partners Foundation
AstraZeneca

Recruiting

Immunotherapy, Chemotherapy, Radiotherapy and Surgery for Synchronous Oligo-metastatic NSCLC (CHESS)

Non-small Cell Lung Cancer | Oligometastasis | Stage IV

Switzerland, Netherlands, Spain, Italy
Shanghai EpimAb Biotherapeutics Co., Ltd.
Covance

Recruiting

A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors

Neoplasms | Neoplasm Metastasis | Non-Small-Cell Lung Cancer

United States, China
Mirati Therapeutics Inc.
Bristol-Myers Squibb

Active, not recruiting

Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (SAPPHIRE)

Metastatic Non-Squamous Non-Small Cell Lung Cancer

United States, Canada, Belgium, France, Germany, Hungary, Israel, Italy, Netherlands, Spain, Switzerland, United Kingdom
SWOG Cancer Research Network
National Cancer Institute (NCI)

Completed

Lung-MAP: Durvalumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers

Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7

United States
Crozer-Keystone Health System
Saint Peters University Hospital; Community Medical Center, Toms River, NJ

Completed

Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) Effect (I-SABR)

Non Small Cell Lung Cancer | Metastatic Nonsmall Cell Lung Cancer

United States
Intergroupe Francophone de Cancerologie Thoracique
Novartis

Completed

BRAF V600-mutated Lung Carcinoma Treated With the Combination of Dabrafenib-trametinib: a Retrospective Evaluation (BLaDE)

Non Small Cell Lung Cancer | BRAF V600 Mutation

France
Samus Therapeutics, Inc.

Withdrawn

A Study of Zelavespib (PU-H71) in Subjects With AP-MPN or BP-MPN (AP-MPN)

Accelerated Phase MPN | Blast Phase MPN
Bristol-Myers Squibb

Completed

Study of Chinese Newly Diagnosed Participants With Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP)

Chronic Myeloid Leukemia | Philadelphia Chromosome | Chronic Myeloid Leukemia in Chronic Phase

China
West China Hospital

Completed

Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma

Kaposiform Hemangioendothelioma | Kasabach Merritt Phenomenon

China
Southwest Oncology Group

Completed

Lung-MAP S1400K: c-MET Positive

Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC V7

United States
Weill Medical College of Cornell University

Terminated

A Phase II Randomized Trial of Immunotherapy Plus Radiotherapy in Metastatic Genitourinary Cancers

Metastatic Renal Cell Carcinoma | Metastatic Urothelial Carcinoma

United States
AstraZeneca

Completed

Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung Cancer (BLOOM)

EGFR Mutation Positive Advanced Non Small Cell Lung Cancer

United States, Korea, Republic of, Taiwan, Australia
M.D. Anderson Cancer Center
Bristol-Myers Squibb

Terminated

An Open-Label, Phase I/II Study of Two Different Schedules of Dasatinib (Sprycel) and Decitabine (Dacogen) Used in Combination for Patients With Accelerated or Blastic Phase Chronic Myelogenous Leukemia (Protocol CA180357)

Leukemia

United States

Clinical Trials on Central Nervous System Disease

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