Clinical Trials on ChAdOx1 nCoV-19 Vaccine in South Africa

Total 65 results

EyeGene Inc.
Novotech (Australia) Pty Limited

Active, not recruiting

Study to Assess the Safety, Tolerability and Explore the Immunogenicity of EG-COVID and EG-COVARo in Healthy Adult Volunteers

COVID-19 Vaccine

Australia
University of Witwatersrand, South Africa
SynaVir

Completed

Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19 (DuACT)

Covid19 | SARS-CoV Infection

South Africa
University of Witwatersrand, South Africa

Completed

COVID-19 Prophylaxis South Africa (COVER HCW) (COVER)

Covid19 | SARS-CoV Infection

South Africa
IDeA States Pediatric Clinical Trials Network
National Institutes of Health (NIH); University of Nebraska; University of Montana

Active, not recruiting

Improving Pediatric COVID-19 Vaccine Uptake Using an mHealth Tool (MoVeUP)

Telemedicine | Pediatric ALL | Vaccine Hesitancy | COVID-19 Vaccines

United States
Desmond Tutu HIV Foundation
Amsterdam Institute for Global Health and Development; University of Cape Town and other collaborators

Completed

Transmission of Coronavirus Disease 2019 (COVID19) in Crowded Environments (TRACE)

Covid19 | Sars-CoV-2 Infection

South Africa
Providence Therapeutics Holdings Inc.

Completed

PTX-COVID19-B, an mRNA Humoral Vaccine, Intended for Prevention of COVID-19 in a General Population. This Study is Designed to Demonstrate the Safety, Tolerability, and Immunogenicity of PTX-COVID19-B in Comparison to the Pfizer-BioNTech COVID-19 Vaccine.

Covid19 Vaccine

Canada, South Africa
National Institute for Communicable Diseases, South...
Centers for Disease Control and Prevention; Fogarty International Center of... and other collaborators

Active, not recruiting

Household Study of COVID-19, Influenza and RSV Burden, Transmission Dynamics and Viral Interaction in South Africa (PHIRST-C)

Influenza | SARS-CoV-2 Infection | Respiratory Syncytial Virus (RSV)

South Africa
Gritstone bio, Inc.

Completed

Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV)

COVID-19 | SARS-CoV-2

South Africa
Novavax
Bill and Melinda Gates Foundation

Completed

A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults

COVID-19 | SARS-CoV-2 Infection

South Africa
Alvea Holdings, LLC

Completed

Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention

Sars-CoV-2 Infection

South Africa
South African National Blood Service

Unknown

Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19

COVID-19 | SARS-CoV-2 Infection | Severe Acute Respiratory Syndrome Coronavirus 2

South Africa
Leidos Life Sciences
United States Department of Defense

Terminated

Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients (Addendum 2)

COVID-19 | Covid19 | Coronavirus Disease 2019 | SARS-CoV2 Infection | SARS-CoV-2 Acute Respiratory Disease | COVID-19 Pandemic | COVID-19 Virus Infection | COVID-19 Virus Disease | 2019 Novel Coronavirus Disease | 2019 Novel Coronavirus Infection | 2019-nCoV Disease | 2019-nCoV Infection

United States
Henry M. Jackson Foundation for the Advancement...
RedHill Biopharma Limited; FHI Clinical, Inc.; Joint Program Executive Office...

Recruiting

PROTECT-APT 1: Early Treatment and Post-Exposure Prophylaxis of COVID-19 (PROTECT-APT 1)

SARS-CoV-2

United States, Côte D'Ivoire, South Africa, Thailand
Novavax

Completed

A Study to Evaluate Safety and Immunogenicity of a COVID-19 Vaccine in People Living With HIV at Risk for SARS-CoV-2 (COVID-19) (COVID-19)

SARS-CoV-2 Infection

South Africa
Wits Health Consortium (Pty) Ltd
Fred Hutchinson Cancer Center; Janssen Vaccines & Prevention B.V.; Right to Care and other collaborators

Recruiting

Sisonke 2 - A COVID-19 Vaccine Boost Open Label Study. (Sisonke Boost)

SARS CoV 2 Infection

South Africa
University of Melbourne
Australian and New Zealand Intensive Care Research Centre; The Peter Doherty... and other collaborators

Active, not recruiting

Australasian COVID-19 Trial (ASCOT) ADAptive Platform Trial (ASCOT)

SARS-CoV-2 Infection (COVID-19)

Australia
Technovalia, Pty Ltd
Chulalongkorn University; Southern Star Research Pty Ltd.; BioNet-Asia

Active, not recruiting

Immunogenicity and Safety of ChulaCov19 BNA159 and ChulaCov19 BNA159.2 Vaccines as a Booster Dose in Adults

COVID-19, SARS CoV 2 Infection

Australia
AstraZeneca

Completed

Phase II/III Study of AZD2816, for the Prevention of COVID-19 in Adults (AZD2816)

COVID-19 | SARS-CoV-2

United Kingdom, Brazil, South Africa, Poland
Prisma Health-Upstate

Completed

COVID-19 on Placental Gene Expression and Pathology (PROSPER)

COVID-19 | SARS-CoV-2 Infection

United States
Masaryk University
University of Kiel; University of Giessen; F.D. Roosevelt Teaching Hospital with... and other collaborators

Unknown

Oral Side Effects of COVID-19 Vaccine

Covid19 | Vaccine Adverse Reaction | Oral Manifestations

Czechia, Germany, Slovakia
Sanford Health

Terminated

Hydroxychloroquine as Post-Exposure Prophylaxis Against COVID-19 Infection

COVID-19 | SARS-CoV 2

United States
ModernaTX, Inc.

Recruiting

A Study of an Investigational mRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated Adults

SARS-CoV-2

Australia
BioNTech SE

Completed

Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants

COVID-19 | SARS-CoV2 Infection | SARS-CoV-2 Acute Respiratory Disease | SARS (Disease)

United States, Germany, Turkey, South Africa
Novavax

Completed

Phase 3 Boosting Study for the SARS-CoV-2 rS Variant Vaccines (COVID-19)

COVID-19 | SARS CoV 2 Infection

Australia
AstraZeneca

Completed

LatInamerican Vaccine Effectiveness Against Hospitalizations Due to Circulating COVID-19 VoC RWE Study (LIVE)

COVID-19, SARS-CoV-2

Mexico, Brazil, Colombia, Costa Rica, Panama
ACM Biolabs

Completed

Booster Dose Study to Assess the Safety and Immunogenicity of ACM-001 Administered Intramuscularly or Intranasally.

SARS-CoV-2 Infection

Australia
University of Melbourne
London School of Hygiene and Tropical Medicine; The Alfred; University of Adelaide and other collaborators

Recruiting

Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection

Influenza, Human | SARS-CoV-2 Infection

Australia
GlaxoSmithKline
CureVac

Active, not recruiting

A Study on the Safety and Immune Response of Investigational COVID-19 mRNA Vaccines in Healthy Adults

SARS-CoV-2

Australia, United States
AstraZeneca

Active, not recruiting

A Randomized Trial Evaluating a mRNA-VLP Vaccine's Immunogenicity and Safety for COVID-19 (ARTEMIS-C)

COVID-19 | SARS-CoV-2 Infection

United States
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); HIV Prevention...

Completed

Characterizing SARS-CoV-2-specific Immunity in Individuals Who Have Recovered From COVID-19

COVID-19 | SARS-CoV-2

United States, Zimbabwe, Malawi, Peru, South Africa, Zambia
COVID-19 Prevention Network
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Study of Immune Responses to the Virus That Causes COVID-19 (CoVPN 5001)

COVID-19 | SARS-CoV-2

United States, Malawi, Zimbabwe, Botswana, South Africa, Zambia, Argentina, Brazil, Mexico, Peru, Tanzania
Restem, LLC.

Completed

Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS (ULSC)

Covid19 | Corona Virus Infection | ARDS | SARS-CoV Infection | Coronavirus

United States
University of Chile
Columbia University

Recruiting

The Covid-19 HEalth caRe wOrkErS (HEROES) Study (HEROES)

Depression | Covid-19 | Anxiety | Mental Health Disorder | SARS-CoV-2 | Stress Disorder

United States, Italy, Argentina, Armenia, Australia, Bolivia, Chile, Costa Rica, Czechia, Germany, Guatemala, Lebanon, Mexico, Netherlands, Nigeria, Puerto Rico, Saudi Arabia, Spain, Tunisia, Turkey, Venezuela
BioNTech SE
Pfizer

Completed

A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children

SARS-CoV-2 Infection, COVID-19

United States, Spain, Finland, Poland, Mexico, Brazil
COVID-19 Prevention Network
National Institute of Allergy and Infectious Diseases (NIAID); Medical Research...

Completed

Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern (CoVPN3008)

HIV Infections | COVID-19 | SARS-CoV-2 Infection

Uganda, Malawi, South Africa, Botswana, Zambia, Kenya, Swaziland
Novavax

Completed

Evaluation of the Safety and Immunogenicity of Influenza and COVID-19 Combination Vaccine

Covid19 | SARS-CoV Infection

Australia
BioNTech SE
Pfizer

Completed

To Evaluate the Safety, Tolerability, and Immunogenicity of BNT162b2 Against COVID-19 in Healthy Pregnant Women 18 Years of Age and Older

COVID-19 | SARS-CoV-2 Infection | Maternal Immunization

United States, United Kingdom, Spain, Brazil, South Africa
AstraZeneca

Active, not recruiting

Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study (SUPERNOVA)

COVID-19, SARS-CoV-2

United States, Belgium, Canada, France, Spain, Denmark, Thailand, Vietnam, Korea, Republic of, United Kingdom, Malaysia, Israel, Taiwan, Australia, Germany, Poland, Singapore, United Arab Emirates
BioNTech SE
Pfizer

Completed

Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals

COVID-19 | SARS-CoV-2 Infection

United States, Germany, Turkey, South Africa, Argentina, Brazil
BioNTech SE
Pfizer

Completed

To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age.

COVID-19 | SARS-CoV-2 Infection

United States, Brazil, South Africa, Germany, Canada, Israel
Center Trials & Treatment
Oleg Martynenko

Terminated

A Randomized Study to Determine the Expression of the Furin Protein in Patients With SARS-CoV-2 and Vaccinated Against Coronavirus

COVID-19 | SARS-CoV-2 | Furin | RGMc Processing | Paired Basic Amino Acid Cleaving Enzyme (PACE)

India, United States, Ukraine
Pfizer

Completed

Safety and Immunogenicity of BNT162b2 Coadministered With SIIV in Adults 18 Through 64 Years of Age

COVID-19 | SARS-CoV-2 Infection

Australia, New Zealand
BioNTech SE
Pfizer

Completed

Safety and Immunogenicity of BNT162b2 Coadministered With SIIV in Adults 18 Through 64 Years of Age

COVID-19 | SARS-CoV-2 Infection

Australia, New Zealand
GlaxoSmithKline

Completed

Safety and Immunogenicity Study of a Booster Dose of the Investigational CV0501 mRNA COVID-19 Vaccine in Adults at Least 18 Years Old

COVID-19 | SARS-CoV-2

Australia, United States, Philippines
Regeneron Pharmaceuticals

Terminated

COVID-19 Study to Evaluate Safety, Tolerability, and Efficacy of REGN14256+Imdevimab for the Treatment of COVID-19 Adult and Adolescent Patients Without Risk Factors for Progression to Severe Disease

SARS-CoV-2

United States
BioNTech SE
Pfizer

Active, not recruiting

A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals

COVID-19 | SARS-CoV-2 Infection

United States
National Institute of Allergy and Infectious Diseases...
Autoimmunity Centers of Excellence; Clinical Trials in Organ Transplantation...

Completed

COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19) | Multisystem Inflammatory Syndrome in Children (MIS-C)

United States
AstraZeneca
Iqvia Pty Ltd

Completed

Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults

COVID-19 | SARS-CoV-2

United States, Chile, Peru
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Understanding the Long-term Impact of COVID on Children and Families

SARS-CoV-2 Infection

United States
Pfizer

Completed

A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not Hospitalized

SARS-CoV-2 Infection

United States

Clinical Trials on ChAdOx1 nCoV-19 Vaccine in South Africa

Sponsors and Collaborators

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CROs in Tanzania

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