Clinical Trials on Chediak-Higashi Syndrome in South Africa

Total 1619 results

International Partnership for Microbicides, Inc.

Withdrawn

A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa

HIV Infections

South Africa, Malawi, Rwanda, Zimbabwe
PENTA Foundation
Baylor College of Medicine; University Hospital Birmingham NHS Foundation Trust and other collaborators

Recruiting

DTG/3TC Fixed Dose Formulations for the Maintenance of Virological Suppression in Children With HIV Infection Aged 2 to <15 Years Old (D3 (Penta21))

HIV Infections

Spain, United Kingdom, Thailand, South Africa, Uganda
National Institute of Allergy and Infectious Diseases...

Completed

Acute HIV Infection Observational Study

HIV Infections

United States, Malawi, South Africa, Tanzania, Uganda
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Drug Detection Study of Dapivirine Vaginal Ring and Oral TRUVADA® in Breastfeeding Mother-Infant Pairs

HIV Infections

South Africa, Uganda, Malawi, Zimbabwe
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID)

Not yet recruiting

Evaluating the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibodies in Healthy Participants (HVTN143)

HIV Infections

South Africa
Gilead Sciences

Completed

Pharmacokinetics, Safety, and Efficacy of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate Single Tablet Regimen (STR) in Adolescents

HIV Infections | Acquired Immunodeficiency Syndrome

United States, Thailand, South Africa
BioCryst Pharmaceuticals

Terminated

A Long Term Safety Study of BCX9930 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria | PNH

United Kingdom, Austria, South Africa
National Institute of Allergy and Infectious Diseases...
HIV Vaccine Trials Network

Completed

Safety of and Immune Response to Two HIV Vaccines: SAAVI DNA-C2 Boosted With SAAVIMVA-C, in HIV-Negative Adults

HIV Infections

United States, South Africa
HIV Prevention Trials Network

Completed

The ADAPT Study: Use of Emtricitabine and Tenofovir Disoproxil Fumarate for Pre-Exposure Prophylaxis (PrEP) (ADAPT)

HIV Infections

United States, South Africa, Thailand
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety and Immune Response to an HIV Vaccine Boost Following the Administration of Two HIV Vaccines, in HIV-Uninfected, Healthy Adults (Study Extension to HVTN 073/SAAVI 102)

HIV Infections

United States, South Africa
University of Oxford
Bill and Melinda Gates Foundation; Department for International Development... and other collaborators

Recruiting

Randomised Evaluation of COVID-19 Therapy (RECOVERY)

Severe Acute Respiratory Syndrome

Ghana, Indonesia, Nepal, South Africa, United Kingdom, Vietnam, India
Massachusetts General Hospital
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Active, not recruiting

Mechanisms of Cardiac Dysfunction in HIV and the Effect of Statins: A Cardiac MRI Study

HIV Infections

United States, South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety of and Adherence to a Vaginal Matrix Ring Containing Dapivirine and Oral Emtricitabine/Tenofovir Disoproxil Fumarate in an Adolescent and Young Adult Female Population

HIV Infections

South Africa, Uganda, Zimbabwe
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV Therapy

HIV Infections

Malawi, South Africa, India, Tanzania, Thailand
BioCryst Pharmaceuticals

Terminated

BCX9930 for the Treatment of PNH in Subjects Not Receiving Other Complement Inhibitor Therapy (REDEEM-2)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Malaysia, South Africa, Korea, Republic of
International Partnership for Microbicides, Inc.

Withdrawn

A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa

HIV Infections

South Africa, Kenya, Malawi
National Institute of Allergy and Infectious Diseases...
National Institute on Drug Abuse (NIDA); Eunice Kennedy Shriver National Institute... and other collaborators

Completed

Using Nevirapine to Prevent Mother-to-Child HIV Transmission During Breastfeeding

HIV Infections

Zimbabwe, South Africa, Tanzania, Uganda
National Institute of Allergy and Infectious Diseases...
Gilead Sciences

Completed

Evaluating the Pharmacokinetics, Feasibility, Acceptability, and Safety of Oral Pre-Exposure Prophylaxis for HIV Prevention During Pregnancy and Postpartum

HIV Infections

Malawi, Zimbabwe, South Africa, Uganda
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries (PROMISE)

HIV Infections

Malawi, South Africa, Tanzania, Zimbabwe, India, Uganda, Zambia
Otsuka Australia Pharmaceutical Pty Ltd

Completed

Refine and Assess the Readability of Patient, Carer, and Clinician Treatment Preference in Myelodysplasia Questionnaire (TPMQ)

Myelodysplastic Syndrome (MDS)

Australia
National Institute of Allergy and Infectious Diseases...
HIV Vaccine Trials Network

Completed

Safety and Efficacy of a Three-Dose Regimen of an Adenoviral HIV Vaccine (MRKAd5 HIV-1 Gag/Pol/Nef) in HIV Uninfected South African Adults

HIV Infections

South Africa
AlphaVax, Inc.
National Institute of Allergy and Infectious Diseases (NIAID); HIV Vaccine...

Completed

Safety of an HIV Vaccine (AVX101) in HIV Uninfected Volunteers in the United States and South Africa

HIV Infections

United States, South Africa
Medical University of South Carolina

Terminated

Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Myelodysplastic Syndromes | Leukemia

United States
Sheffield Children's NHS Foundation Trust

Completed

Paediatric Oximetry Algorithms - Normative Data Collection

Sleep Apnea Syndromes in Children

United Kingdom
International AIDS Vaccine Initiative
National Institute of Allergy and Infectious Diseases (NIAID); Beth Israel... and other collaborators

Completed

Safety and Immunogenicity Study of Ad26-ENVA and Ad35-ENV HIV Vaccines in Healthy HIV-uninfected Adults

HIV Infections

United States, Kenya, Rwanda, South Africa
AlphaVax, Inc.
National Institute of Allergy and Infectious Diseases (NIAID); HIV Vaccine...

Completed

Safety of and Immune Response to an HIV-1 Subtype C Vaccine (AVX101) in HIV Uninfected Adults

HIV Infections

United States, Botswana, South Africa
Janssen R&D Ireland

Completed

TMC125-TiDP2-C238: An Exploratory Pharmacokinetics, Safety and Anti-HIV Activity Study of Etravirine (ETR) When Given With Boosted Atazanavir (ATV/Rtv) at Two Different Doses and 1 Nucleoside Reverse Transcriptase Inhibitor (NRTI) in Treatment Experienced HIV Patients

HIV Infections | Acquired Immunodeficiency Syndrome

United States, France, Argentina, South Africa, Thailand
Seagen Inc.

Completed

A Phase I Study of Lintuzumab Combined With Lenalidomide in Patients With Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndrome (MDS)

United States
Larry Cripe, MD
Celgene Corporation; Ortho Biotech Clinical Affairs, L.L.C.; Walther Cancer Institute

Terminated

Azacitidine and Erythropoietin Versus Azacitidine Alone for Patients With Low-Risk Myelodysplastic Syndromes

Myelodysplastic Syndromes

United States
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety, Pharmacokinetics, and Anti-Viral Activity of VRC01 and VRC01LS in the Serum and Mucosa of Healthy, HIV-Uninfected Adults

HIV Infections

United States, South Africa
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Exploring Novel Mechanisms of Vaccine Failure LAIV Pilot Study (LAIV)

Acquired Immune Deficiency Syndrome Virus

United Kingdom
Bristol-Myers Squibb

Terminated

Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome

Sjögren's Syndrome

Australia, United States, Italy, Mexico, Colombia, Peru, Puerto Rico, South Africa, Chile, Poland, Russian Federation
International Partnership for Microbicides, Inc.

Completed

Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women

HIV Infections

South Africa, Uganda
National Institute of Allergy and Infectious Diseases...
Novartis Vaccines; HIV Vaccine Trials Network; IPPOX Foundation

Completed

Safety and Immune Response to a Clade C DNA HIV Vaccine (HVTN111)

HIV Infections

South Africa, Zambia, Tanzania
ViiV Healthcare

Active, not recruiting

Safety and Efficacy of Dolutegravir/Lamivudine (DTG/3TC) in Therapy-naive Human Immunodeficiency Virus-1 (HIV-1) Infected Adolescents

HIV Infections

Thailand, Kenya, South Africa
Medical University of South Carolina

Completed

Evaluation of Blink Tears and Systane Concomitant With Restasis for the Treatment of Dry Eye Symptoms

Dry Eye Syndrome

United States
International Partnership for Microbicides, Inc.
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Phase 3 Safety and Effectiveness Trial of Dapivirine Vaginal Ring for Prevention of HIV-1 in Women (ASPIRE)

HIV Infections

Malawi, South Africa, Uganda, Zimbabwe
Novartis Pharmaceuticals

Terminated

Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Syndrome.

Familial Chylomicronemia Syndrome (FCS) (HLP Type I)

South Africa, Germany, United Kingdom, France, United States, Canada, Netherlands
AbbVie
Celgene; Genentech, Inc.

Completed

A Study Evaluating Venetoclax Alone and in Combination With Azacitidine in Participants With Relapsed/Refractory Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes (MDS)

United States, Australia, Germany
Kirby Institute

Active, not recruiting

Body Composition Sub-study of the D2EFT Trial

HIV Infections

Malaysia, Zimbabwe, India, South Africa, Thailand
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients (1 to 3)

Tuberculosis | HIV Seropositivity | Household Contact

South Africa, India, Indonesia, Mozambique
University of California, Los Angeles
National Institute of Mental Health (NIMH); HIV Prevention Trials Network

Completed

Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand

HIV Infections

South Africa, Tanzania, Thailand, Zimbabwe
Onconova Therapeutics, Inc.

Completed

Efficacy and Safety of Oral Rigosertib in Transfusion-dependent, Low or Int-1 or Trisomy 8 Int-2 Myelodysplastic Syndrome (ONTARGET)

Myelodysplastic Syndrome | MDS | Trisomy 8

United States
Eisai Inc.

Completed

Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic Drugs

Lennox-Gastaut Syndrome

France, Poland, United States, South Africa, Italy, Canada, Greece
European Working Group of MDS in Childhood

Unknown

Studying Blood Samples in Young Patients With Cytopenia After a Donor Stem Cell Transplant

Myelodysplastic Syndromes | Leukemia

Germany, Austria, Switzerland, Czech Republic, Netherlands, Denmark, Belgium, Italy, Poland
AO Clinical Investigation and Publishing Documentation

Recruiting

Alloplastic Total Temporomandibular Joint (TMJ) Replacement Registry

Temporomandibular Joint Disorders

Sweden, Germany, Switzerland, Poland, Serbia, Brazil, Colombia, India, Netherlands, New Zealand, Russian Federation, Spain, Pakistan, South Africa
Janssen-Cilag International NV

Completed

A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line Treatment (SALIF)

Human Immunodeficiency Virus-type 1 Infection

South Africa, Kenya, Thailand, Uganda, Cameroon, Senegal
Bristol-Myers Squibb

Completed

Pharmacokinetics of Atazanavir/Ritonavir in HIV-1 Infected Pregnant Women

HIV Infection

South Africa, Puerto Rico, United States
Imago BioSciences, Inc., a subsidiary of Merck...

Completed

A Study of Bomedemstat (IMG-7289/MK-3543) With and Without ATRA, in Participants With Advanced Myeloid Malignancies (IMG-7289-CTP-101/MK-3543-001)

Acute Myeloid Leukemia | Myelodysplastic Syndrome

Australia
National Institute of Allergy and Infectious Diseases...
GlaxoSmithKline; Sanofi Pasteur, a Sanofi Company; HIV Vaccine Trials Network

Completed

Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine (HVTN107)

HIV Infections

South Africa, Mozambique, Zimbabwe

Clinical Trials on Chediak-Higashi Syndrome in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Czech Republic

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Rare Diseases

Drug Interventions

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Sponsor/Collaborators

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