Clinical Trials on Childhood Hypophosphatasia

Total 1948 results

Translational Research Center for Medical Innovation...
Osaka University Graduate School of Medicine

Completed

Safety and Efficacy of Asfotase Alfa in Patients With Hypophosphatasia (HPP)

Hypophosphatasia

Japan
Gumy-Pause Fabienne

Recruiting

Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment

Childhood Cancer | Fertility Disorders

Switzerland
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

Neuropsychological and Behavioral Testing in Younger Patients With Cancer

Childhood Malignant Neoplasm

United States, Canada, Puerto Rico, Australia, New Zealand
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors

Childhood Malignant Neoplasm

United States, Canada, Australia, Puerto Rico, Switzerland
Centre Oscar Lambret
Bristol-Myers Squibb; Anticancer Fund, Belgium; CTD-CNO; ECS-Progastrin SA

Active, not recruiting

Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors

Childhood Solid Tumor

France, Belgium
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Prospective Trial of Vaccine Responses in Childhood Cancer Survivors

Childhood Cancer | Multiple Diseases

United States
Kahramanmaras Sutcu Imam University

Completed

Thiol/Disulfide and Oxidative Stress

Severe Early Childhood Caries

Turkey
Mathematica Policy Research, Inc.
The University of Texas Health Science Center, Houston; Department of Health... and other collaborators

Unknown

Study of Coaching Practices in Early Care and Education Settings (SCOPE)

Early Childhood Professional Development

United States
The University of Hong Kong

Completed

Effectiveness of an Integrated Programme in Promoting the Regular Physical Activity Among Childhood Cancer Survivors

Malignant Childhood Neoplasm

China
National Cancer Institute (NCI)

Terminated

Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia

Recurrent Childhood Acute Lymphoblastic Leukemia | B-cell Childhood Acute Lymphoblastic Leukemia | Childhood Diffuse Large Cell Lymphoma | Childhood Immunoblastic Large Cell Lymphoma | Recurrent Childhood Large Cell Lymphoma | Recurrent Childhood Lymphoblastic Lymphoma | Recurrent Childhood Small... and other conditions

United States
Medialis Ltd.
Metabolic Support UK

Completed

Retrospective and Prospective Disease Progression and Quality of Life in XLH

X-linked Hypophosphatemia (XLH)

United Kingdom
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma

Childhood Diffuse Large Cell Lymphoma | Childhood Immunoblastic Large Cell Lymphoma | Childhood Burkitt Lymphoma | Untreated Childhood Acute Lymphoblastic Leukemia | Stage I Childhood Large Cell Lymphoma | Stage I Childhood Small Noncleaved Cell Lymphoma | Stage II Childhood Large Cell Lymphoma | Stage II Childhood Small Noncleaved Cell Lymphoma and other conditions

United States
University Hospital, Brest

Completed

Hypophosphatemia as a Predictor in Surgical Resuscitation Sepsis

Infection | Hypophosphatemia

France
Istanbul Bilgi University
Center for Regulation Focused Psychotherapy

Recruiting

Randomized Controlled Trial of Regulation-Focused Psychotherapy (RFP-C)

Childhood Externalizing Disorder | Childhood Oppositional Defiant Disorder | Childhood Conduct Disorder

Turkey
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Studying Biomarkers in Samples From Younger Patients With Acute Myeloid Leukemia

Childhood Acute Monoblastic Leukemia (M5a) | Childhood Acute Monocytic Leukemia (M5b) | Childhood Acute Myeloblastic Leukemia Without Maturation (M1) | Childhood Acute Myelomonocytic Leukemia (M4) | Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies

United States
Rigshospitalet, Denmark

Recruiting

Home Chemotherapy Intervention for Children With Cancer - a Feasibility Study (INTACTatHome)

Childhood Cancer | Supportive Care

Denmark
Necmettin Erbakan University

Completed

Intervention to Promote Childhood Vaccinations and Influence Vaccination Attitudes

Vaccine Hesitancy | Childhood Vaccination

Turkey
Jonsson Comprehensive Cancer Center

Withdrawn

A Mobile Phone Intervention to Promote Adherence to Survivorship Care Among Adolescent and Young Adult Cancer Survivors

Survivors of Childhood Cancer

United States
National Cancer Institute (NCI)

Completed

Radiation Therapy and the Natural History of Childhood Cancers

Cancer | Childhood Malignancy

United States
Mathematica Policy Research, Inc.
University of Oklahoma; Department of Health and Human Services; Zero to Three

Unknown

Professional Development Tools to Improve the Quality of Infant and Toddler Care (Q-CCIIT PD)

Early Childhood Professional Development
Activartis Biotech

Completed

Cancer Immune Therapy for the Treatment of Refractory Solid Tumours of Childhood

Childhood Solid Tumor

Austria
Hospital Infantil Universitario Niño Jesús, Madrid...
SPANISH HEALTH RESEARCH FUND (FIS)

Terminated

Haploidentical Stem Cell Transplantation and IL-15 NK Cell Infusion for Paediatric Refractory Solid Tumours (NK)

Childhood Solid Tumor

Spain
University of Oklahoma

Withdrawn

Heart Safety Study of Ondansetron in Children Receiving Chemotherapy

Malignant Childhood Neoplasm

United States
National Cancer Institute (NCI)

Completed

Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Recurrent Childhood Acute Lymphoblastic Leukemia | L1 Childhood Acute Lymphoblastic Leukemia | L2 Childhood Acute Lymphoblastic Leukemia | T-cell Childhood Acute Lymphoblastic Leukemia | Non-T, Non-B Childhood Acute Lymphoblastic Leukemia

United States
National and Kapodistrian University of Athens

Not yet recruiting

The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing (SynAir-Child)

Childhood Asthma | Environmental Exposure | Pollution; Exposure | Childhood
Alexion Pharmaceuticals

Approved for marketing

Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP)

Hypophosphatasia

United States, France
Alexion Pharmaceuticals

Completed

Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)

Hypophosphatasia

United States, Spain, Australia, United Kingdom, Italy, France, Canada, Germany, Japan, Russian Federation, Saudi Arabia, Turkey
National Institute of Mental Health (NIMH)

Terminated

Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia

Mental Disorders | Schizophrenia | Psychosis | Childhood Onset Psychotic Disorders

United States
National Cancer Institute (NCI)

Completed

Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma

Rhabdomyosarcoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Childhood Angiosarcoma | Childhood Epithelioid Sarcoma | Childhood... and other conditions

United States, Canada
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission

Childhood Acute Lymphoblastic Leukemia in Remission | Graft Versus Host Disease | B-cell Childhood Acute Lymphoblastic Leukemia | L1 Childhood Acute Lymphoblastic Leukemia | L2 Childhood Acute Lymphoblastic Leukemia | T-cell Childhood Acute Lymphoblastic Leukemia

United States, Canada, Australia
National Cancer Institute (NCI)

Completed

Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas

Unspecified Childhood Solid Tumor, Protocol Specific | Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Recurrent Melanoma | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Recurrent Colon Cancer | Recurrent Wilms Tumor and Other Childhood... and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors

Glioma | Recurrent Childhood Medulloblastoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Diffuse Intrinsic Pontine Glioma | Refractory Brain Neoplasm | Recurrent Childhood Anaplastic Oligodendroglioma | Recurrent Childhood Glioblastoma | Recurrent Primitive Neuroectodermal Tumor | Childhood Astrocytoma and other conditions

United States
Hospices Civils de Lyon

Completed

Brain Maturation in Children With Localization Related Epilepsy (DYNAMAT)

Benign Childhood Epilepsy With Centro-temporal Spikes (BCECTS) | Focal Cryptogenic Epilepsy of Childhood | Cryptogenic Epilepsy of Childhood

France
National Cancer Institute (NCI)

Completed

Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

Stage IV Adult Soft Tissue Sarcoma | Adult Rhabdomyosarcoma | Metastatic Childhood Soft Tissue Sarcoma | Childhood Alveolar Rhabdomyosarcoma | Childhood Embryonal Rhabdomyosarcoma | Untreated Childhood Rhabdomyosarcoma

United States, Canada, Australia, New Zealand
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)

X-linked Hypophosphatemia

United States, Korea, Republic of, Canada, Japan, France, Denmark
Kyowa Hakko Kirin Pharma, Inc.
Kyowa Kirin Co., Ltd.

Completed

An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia

X-linked Hypophosphatemia

United States, Canada
Kaohsiung Medical University Chung-Ho Memorial...

Completed

Resilience Models in Adolescence and Youth With Cancer in Taiwan

Childhood Cancer | Coping Behavior | Resilience | Hope

Taiwan
Georgetown University
National Cancer Institute (NCI)

Completed

Telephone-Based Cancer Education With or Without Telephone-Based Counseling in Young Participants

Unspecified Childhood Solid Tumor, Protocol Specific

United States
Children's Cancer and Leukaemia Group

Unknown

Pharmacokinetics of Dactinomycin in Young Patients With Cancer

Unspecified Childhood Solid Tumor, Protocol Specific

Ireland, United Kingdom
National Cancer Institute (NCI)

Completed

Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia

Unspecified Childhood Solid Tumor, Protocol Specific | Juvenile Myelomonocytic Leukemia | Recurrent Childhood Medulloblastoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Childhood Acute Promyelocytic Leukemia (M3) | Childhood Chronic Myelogenous Leukemia | Recurrent Childhood Acute Lymphoblastic... and other conditions

United States
University of California, Los Angeles
Kaiser Permanente School of Medicine

Completed

Testing a Scalable Model For ACEs-Related Care Navigation

Child Development | Adverse Childhood Experiences

United States
University of Pittsburgh
National Institutes of Health (NIH); National Institute on Aging (NIA)

Terminated

Physical Exercise for Augmenting Cognitive Health (PEACH) (PEACH)

Cognitive Aging | Adverse Childhood Experiences

Jamaica, United States
University of Zurich
University Children's Hospital Basel

Completed

SURfit - A Physical Activity Intervention for Childhood Cancer Survivors (SURfit)

Late-effects of Childhood Cancer

Switzerland
National Cancer Institute (NCI)

Completed

Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment

Recurrent Childhood Ependymoma | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Recurrent Renal Cell Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal... and other conditions

United States
Alexion Pharmaceuticals, Inc.

Not yet recruiting

Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP (MULBERRY)

Hypophosphatasia

United States, Taiwan, Thailand, Vietnam, United Kingdom, Korea, Republic of, Israel, Italy, Australia, Turkey, France, Poland, Germany, Spain, Belgium, China, Canada, Brazil, Argentina, Mexico
Alexion Pharmaceuticals, Inc.

Recruiting

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa (HICKORY)

Hypophosphatasia

Italy, Spain, Israel, Korea, Republic of, Belgium, Germany, United States, China, France, Taiwan, Austria, Japan, India, Australia, Argentina, Poland, Turkey, Brazil, Thailand, United Kingdom, Canada, Slovakia, Czechia
Alexion Pharmaceuticals, Inc.

Completed

Study of ALXN1850 in Participants With Hypophosphatasia (HPP)

Hypophosphatasia

United States
AM-Pharma

Completed

Pilot Trial of Single Dose Ilofotase Alfa in Hypophosphatasia

Hypophosphatasia

Germany
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Health Burden of Hypophosphatasia

Hypophosphatasia

United Kingdom
Wuerzburg University Hospital

Completed

Burden of Disease in Hypophosphatasia (HPP)

Hypophosphatasia

Germany

Clinical Trials on Childhood Hypophosphatasia

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Denmark

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations