Clinical Trials on Chronic Obstructive Pulmonary Disease Severe

Total 46606 results

Spire, Inc.
ResMed

Completed

An Exploratory, Observational, Non-interventional, Open Label, Remote Pilot Study to Assess Adherence in COPD Subjects

Severe Chronic Obstructive Pulmonary Disease | Moderate Chronic Obstructive Pulmonary Disease

United States
Hopital Foch
Air Liquide SA

Recruiting

Exploration of the VOLATOLOM in the Stable Severe COPD (Chronic Obstructive Pulmonary Disease) (VOC-BPCO)

Chronic Obstructive Pulmonary Disease Severe

France
University Hospital, Tours

Completed

Evaluation of Benefit of Nebulized Bronchodilators at Home in Severe Chronic Obstructive Pulmonary Disease and Very Severe Steady State (Nebuadom)

Severe Chronic Obstructive Pulmonary Disease

France
Hospital de Mataró

Completed

Urban Walking Circuits

Severe Chronic Obstructive Pulmonary Disease

Spain
Schön Klinik Berchtesgadener Land
ResMed

Completed

Effects of Different Oxygen Devices in Hypoxemic COPD Patients

Chronic Obstructive Pulmonary Disease Severe

Germany
Randall Debattista
University of Malta, Faculty of Health Sciences

Not yet recruiting

Effect of NMES on Quadriceps Muscle Strength and Endurance in Patients With COPD (NMES)

Chronic Obstructive Pulmonary Disease Moderate | Acute Exacerbation of COPD | Chronic Obstructive Pulmonary Disease Severe
Taipei Medical University

Unknown

Effects of a Comprehensive Health Coaching Program in Advanced Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary Disease Severe | Chronic Obstructive Pulmonary Disease End Stage

Taiwan
AstraZeneca
MedImmune LLC

Completed

Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History (TERRANOVA)

Moderate to Very Severe Chronic Obstructive Pulmonary Disease

United States, Denmark, France, Sweden, Thailand, Vietnam, Belgium, Brazil, Peru, Philippines, Turkey, Taiwan, Argentina, Australia, Israel, Poland, Ukraine, Slovenia, Serbia, Mexico, Bulgaria, Colombia, New Zealand, Chile, Norway, Croatia
AstraZeneca
MedImmune LLC

Completed

Benralizumab Efficacy in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History (GALATHEA)

Moderate to Very Severe Chronic Obstructive Pulmonary Disease

United States, Canada, Germany, Italy, Netherlands, Spain, United Kingdom, Poland, Japan, Austria, Korea, Republic of, Russian Federation, South Africa, Czechia, Hungary, Romania, Switzerland
Centre Hospitalier Universitaire de Besancon

Unknown

Ventilatory Adaptation to Concentric Versus Eccentric Exercise in Patients With Severe COPD (CONvEX)

Chronic Obstructive Pulmonary Disease Severe

France
Hospital de Clinicas de Porto Alegre
Universidade Federal do Rio de Janeiro; Pontifícia Universidade Católica do...

Recruiting

Cell Therapy Associated With Endobronchial Valve (CEL&VAL)

Chronic Obstructive Pulmonary Disease Severe

Brazil
Chiesi Farmaceutici S.p.A.

Completed

Phase II Study to Evaluate the Cardiac Safety of 2 Doses of CHF5993 Both Combined With CHF1535 BID Versus CHF1535 BID in Patients With Moderate to Severe COPD (CARSAF)

Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Bulgaria, Germany, Hungary, Poland, Russian Federation, United Kingdom
Karaganda Medical University

Completed

Association of Cathelicidin and Vitamin D Levels With the Category and Course of COPD (COPD)

Chronic Obstructive Pulmonary Disease | Chronic Obstructive Pulmonary Disease Moderate | Chronic Obstructive Pulmonary Disease Severe

Kazakhstan
Cliniques universitaires Saint-Luc- Université...

Completed

Breathing Control Exercises in Patients With Chronic Obstructive Pulmonary Disease.

Severe Chronic Obstructive Pulmonary Disease

Belgium
Cukurova University

Completed

Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation

Anesthesia | Chronic Obstructive Pulmonary Disease Moderate | Lungcancer | Chronic Obstructive Pulmonary Disease Severe | Chronic Obstructive Pulmonary Disease Mild

Turkey
University Medical Center Groningen

Completed

The Identification of Phenotypes in Patients With Severe Chronic Obstructive Pulmonary Disease (Groningen Severe COPD Cohort)

Severe COPD
Li An

Recruiting

Risk Prediction Model for Exacerbating Phenotype in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease Severe

China
Guy's and St Thomas' NHS Foundation Trust

Suspended

Efficacy of an Advanced Auto-titrating NIV in COPD

Chronic Obstructive Pulmonary Disease Severe

United Kingdom
Ferran Morell

Not yet recruiting

Severe Prospective Observational COPD Catalonia (SPOCCAT)

Severe Chronic Obstructive Pulmonary Disease
Laval University
Université de Montréal

Unknown

Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chronic Obstructive Pulmonary Disease (CODEx)

Dyspnea | Severe Chronic Obstructive Pulmonary Disease | Moderate Chronic Obstructive Pulmonary Disease

Canada
Johns Hopkins University
Patient-Centered Outcomes Research Institute

Recruiting

Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE) (RELIANCE)

Chronic Bronchitis | Chronic Obstructive Pulmonary Disease Severe

United States
Mabwell (Shanghai) Bioscience Co., Ltd.

Recruiting

Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).

Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

China
Lithuanian University of Health Sciences

Recruiting

Respiratory and Cardiovascular Alterations in Patients With Chronic Obstructive Pulmonary Disease

Cardiovascular Diseases | Quality of Life | Chronic Obstructive Pulmonary Disease Moderate | Chronic Obstructive Pulmonary Disease Severe

Lithuania
Convexity Scientific Inc
COPD Foundation

Completed

Observational Study of the Wellinks Solution Impact on Quality of Life and Clinical Outcomes in Patients With COPD (ASPIRE)

Chronic Obstructive Pulmonary Disease | COPD | Chronic Obstructive Pulmonary Disease Moderate | Chronic Obstructive Pulmonary Disease Severe

United States
AstraZeneca

Completed

Study to Assess the Efficacy and Safety of AZD1981 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (Columbus)

Moderate to Severe COPD

Sweden, Bulgaria, Poland, Denmark, Slovakia
Food and Health Bureau, Hong Kong
Hospital Authority, Hong Kong

Recruiting

A Decision Aid on End-of-life Care for Patients With Advanced COPD and Their Family

Chronic Obstructive Pulmonary Disease Severe

China
AstraZeneca

Completed

Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients. (ASCENT COPD)

Chronic Obstructive Pulmonary Disease | COPD | Moderate to Very Severe COPD

United States, Canada
Hospital Galdakao-Usansolo
Hospital General Universitario Gregorio Marañon; Hospital Donostia; Hospital... and other collaborators

Completed

COPD Readmissions Prediction- ReCOPD Project (ReCOPD)

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Spain
University Hospital, Grenoble

Not yet recruiting

Oral Citrulline Supplementation in COPD Patients With Malnutrition (CITRUS)

Malnutrition | Chronic Obstructive Pulmonary Disease Severe
University Hospital, Clermont-Ferrand

Not yet recruiting

Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition (CYTODINE)

Dyspnea | Chronic Obstructive Pulmonary Disease Severe

France
University Medical Center Groningen

Unknown

An Integrative Genomic Approach to Solve tHe Puzzle of sevERe earLy-Onset COPD (SHERLOCk)

Chronic Obstructive Pulmonary Disease | COPD | Severe Early-Onset COPD | SEO-COPD

Netherlands
Chang Gung Memorial Hospital

Completed

Mobile-phone-based Home Exercise in Chronic Obstructive Pulmonary Disease

Moderate to Severe COPD Receiving Home Exercise Training

Taiwan
Karolinska Institutet
The Swedish Research Council; Göteborg University; University of Bergen; University... and other collaborators

Active, not recruiting

Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease (COSMIC)

Smoking | Chronic Obstructive Pulmonary Disease | Emphysema | Chronic Bronchitis | Chronic Airways Obstruction

Sweden
Istinye University

Completed

Additional Manual Therapy Over Inspiratory Muscle Training in COPD

Muscle Weakness | Chronic Obstructive Pulmonary Disease Severe

Turkey
Breathe Technologies, Inc.

Completed

Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) (PRIDE)

Pulmonary Disease, Chronic Obstructive | Chronic Obstructive Lung Disease | Chronic Obstructive Airway Disease | Airflow Obstruction, Chronic

United States
Skane University Hospital
Lund University; The Swedish Research Council; ResMed; Vastra Gotaland Region; Region... and other collaborators

Not yet recruiting

Effect of HIgh-flow Therapy in Long-term Oxygen Therapy (HILOT)

Interstitial Lung Disease | Chronic Respiratory Failure With Hypoxia | Chronic Obstructive Pulmonary Disease Severe
Tufts Medical Center
Virginia Commonwealth University

Active, not recruiting

Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease | COPD Exacerbation | Airflow Obstruction

United States
Temple University
National Center for Complementary and Integrative Health (NCCIH); Quercegen...

Recruiting

Biological Effects of Quercetin in COPD Phase II (polyphenols)

Chronic Obstructive Pulmonary Disease | Emphysema | Chronic Bronchitis With Airway Obstruction

United States
Hospital Viamed Valvanera, Spain
Campus Bio-Medico University

Completed

Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease (PVR-COPD)

Chronic Obstructive Pulmonary Disease | Pulmonary Hypertension | Cor Pulmonale

Italy
Kronikgune
Odense University Hospital; Assuta Ashdod Hospital; Maccabi Healthcare Services... and other collaborators

Recruiting

Assessment of the Effectiveness, Socio-economic Impact and Implementation of a Digital Solution for Severe Patients (ADLIFE)

Heart Failure NYHA Class III | Heart Failure NYHA Class IV | Chronic Obstructive Pulmonary Disease Severe

Denmark, Germany, Israel, Spain, Sweden, United Kingdom
Northumbria Healthcare NHS Foundation Trust
Newcastle-upon-Tyne Hospitals NHS Trust; National Institute for Health Research... and other collaborators

Completed

Mortality and Symptom Burden Post Hospitalisation With COPD (MoSHCOPD)

Pulmonary Disease, Chronic Obstructive | Emphysema | Chronic Bronchitis | Pulmonary Disease, Obstructive | Chronic Bronchitis With Airways Obstruction | Chronic Bronchitis With Acute Exacerbation

United Kingdom
Shanghai Chest Hospital

Not yet recruiting

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema (BTVA)

Severe Emphysema
Pulmonx Corporation

Recruiting

Zephyr Valve Japan Post-Marketing Surveillance

Emphysema | COPD | Severe Emphysema

Japan
Pulmonx Corporation

Active, not recruiting

Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) (CONVERT)

Emphysema | COPD | Severe Emphysema

United Kingdom, France, Netherlands, Germany, Australia, Italy, Switzerland
Guangzhou Institute of Respiratory Disease
Xiangya Hospital of Central South University; Shanghai Zhongshan Hospital; West... and other collaborators

Unknown

Multicenter Study of Impulse Oscillometry in Chinese

Chronic Obstructive Pulmonary Disease | Asthma | Healthy Subjects | Interstitial Lung Disease | Upper Airway Obstruction

China
Jens Rikardt Andersen

Completed

Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale

Chronic Obstructive Pulmonary Disease | Cor Pulmonale
Kırıkkale University

Recruiting

Evaluation in Elderly Individuals With Chronic Obstructive Pulmonary Disease(COPD)

COPD (Chronic Obstructive Pulmonary Disease)

Turkey
Fundación para la Investigación del Hospital Clínico...

Not yet recruiting

GOLD 0 - DLCO 1: A Look Beyond the Obstruction. Is Spirometry Enough for COPD (Chronic Obstructive Pulmonary Disease) Screening?

COPD, Chronic Obstructive Pulmonary Disease

Spain
Canandaigua VA Medical Center

Recruiting

Manual Therapy in Addition to Pulmonary Rehabilitation in Moderate Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary Disease Moderate

United States
Mylan Inc.
Theravance Biopharma

Completed

Effects of TD-4208 on FEV1 in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease, COPD

New Zealand

Clinical Trials on Chronic Obstructive Pulmonary Disease Severe

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