- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01631019
Mobile-phone-based Home Exercise in Chronic Obstructive Pulmonary Disease
Influence of Long-term Cell-phone Based Home Exercise on Biomarkers, Skeletal Muscle and Mortality in Patients With COPD
Background: Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in Chronic Obstructive Pulmonary Disease (COPD) patients.
Design: To investigate the home-based exercise training program can reduce inflammatory biomarkers in COPD.
Setting: Conducted from January 2007 to December 2007 at a tertiary medical center, Chang Gung Memorial Hospital, Taiwan.
Patients: Moderate to severe COPD receiving home exercise training, 12 using mobile phone assistance and 14 with free walk, were assessed for 6 months.
Measurements: Incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, C-reactive protein (CRP) and inflammatory cytokines.
Study Overview
Status
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Phase 2
Contacts and Locations
Study Locations
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-
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Taoyuan, Taiwan, 333
- Chang Gung memorial hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patients with moderate to severe COPD
Exclusion Criteria:
- requirement for oxygen therapy;
- presence of symptomatic cardiovascular diseases or severe systemic diseases limiting exercise capacity;
- use of medications affecting exercise responses;
- musculoskeletal conditions with exercise performance limitation; and
- impaired hearing or vision that affects subject's ability to follow the exercise training program.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: with mobile phone assistance
In the mobile phone group, patients were asked to continue their exercise program at home at a fixed walking speed.
During this period of time, the adherence to protocol was reinforced by telephone from health professionals whenever patients missed one day of their walking training detected by the central system.
Patients were asked to continue their exercise program at home at a fixed walking speed, and return to the clinic at 1, 2, 3 and 6 months.
|
Patients in the mobile phone group were asked to perform daily endurance exercise training under mobile phone guidance, and the adherence was reported back to the central server.
The level of endurance walking was re-assessed and re-adjusted initially on regular clinical visits every four weeks during the first three months.
During this period of time, the adherence to protocol was reinforced by telephone from health professionals whenever patients missed one day of their walking training detected by the central system.
Patients were asked to continue their exercise program at home at a fixed walking speed, and return to the clinic at 1, 2, 3 and 6 months.
all the subjects were assessed by an incremental shuttle walking test (ISWT) (24) for estimation of exercise endurance.
Baseline spirometry and body mass index (BMI) were recorded.
The adherence and compliance of the home-based exercise training program was assessed by monitoring the frequency of performance and the duration of the endurance walking program recorded on the central system every week.
Patients were asked to continue their exercise program at home at a fixed walking speed, and return to the clinic at 1, 2, 3 and 6 months.
|
Placebo Comparator: with free walk
Patients in the control group were educated the same exercise protocol, but were only verbally asked to freely take the walking exercise training at home.
The adherence to the walking exercise at home was reported by the patients themselves at every return visits.
All the patients received ISWT, spirometry and blood sample for inflammatory biomarkers at baseline, 1, 2, 3 and 6 months.
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all the subjects were assessed by an incremental shuttle walking test (ISWT) (24) for estimation of exercise endurance.
Baseline spirometry and body mass index (BMI) were recorded.
The adherence and compliance of the home-based exercise training program was assessed by monitoring the frequency of performance and the duration of the endurance walking program recorded on the central system every week.
Patients were asked to continue their exercise program at home at a fixed walking speed, and return to the clinic at 1, 2, 3 and 6 months.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
inflammatory cytokines
Time Frame: 6 months
|
IL-8
|
6 months
|
C-reactive protein (CRP)
Time Frame: 6 months
|
CRP as systemic inflamatory status
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6 months
|
Incremental shuttle walk test (ISWT)
Time Frame: 6 months
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Distence of shuttle walking test!
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6 months
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spirometry
Time Frame: 6 months
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FEV1 and FEV1/FVC.
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6 months
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strength of limb muscles
Time Frame: 6 months
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upper and lower limbs stregth
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6 months
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Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 95-1401B
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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