Clinical Trials on Clinical Pharmacology

Total 2873 results

Bayer

Completed

Study to Investigate the Natriuretic Effects, Safety, Tolerability and Pharmacokinetics of BAY94-8862

Clinical Pharmacology

Germany
Bayer
Janssen Research & Development, LLC

Completed

Study to Compare the Effect of the Formulations (Orally Disintegrating Tablet and Film-coated Tablet) on Bioequivalence of Drug Rivaroxaban (Xarelto) at Dose of 10 mg in Japanese Healthy Male Adult Subjects

Clinical Pharmacology

Japan
Takeda

Completed

TAK-114 Single- and Multiple-Dose Phase 1 Study

Clinical Pharmacology

Japan
Guangzhou Lupeng Pharmaceutical Company LTD.

Completed

The Mass Balance Study of LP-168 in Healthy Subjects

Clinical Pharmacology

China
Bayer
Janssen Research & Development, LLC

Completed

Study to Compare the Effect of the Formulations (Orally Disintegrating Tablet and Film-coated Tablet) on the Bioequivalence of Drug Rivaroxaban (Xarelto) at Dose of 15 mg in Japanese Healthy Male Adult Subjects

Clinical Pharmacology

Japan
Bayer

Completed

To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults. (Icicle)

Pharmacology, Clinical

United States
Solvay Pharmaceuticals

Completed

Study to Investigate ADME of 14C Labeled SLV334 After an i.v. Infusion

Pharmacology, Clinical

Netherlands
Takeda

Completed

Effect of Food on the Pharmacokinetics of Single Oral Dose Administration of a Fixed-Dose Combination of SYR-322 and Metformin Hydrochloride in Healthy Adult Male Subjects

Clinical Pharmacology

Japan
Cinfa Biotech

Completed

Pharmacokinetic and Pharmacodynamics of B12019 and Neulasta® in Healthy Subjects

Clinical Pharmacology

Germany
Bayer

Completed

Single Dose Escalation Study to Investigate the Pharmacokinetics as Well as Safety and Tolerability of a Concomitant Administration of Nifedipne GITS and Candesartan Tablets Under Fasting Conditions in Healthy Male Subjects in an Open Label, Non-randomized, Sequential Design.

Clinical Pharmacology

Germany
Bayer

Completed

Bioequivalence Study of BAY 77-1931 Orally Disintegrating Tablet

Clinical Pharmacology

Japan
Bayer

Completed

Relative Bioavailability and Food Effect Study

Pharmacology, Clinical

Germany
Takeda

Completed

A Phase I Clinical Pharmacology Study of TAK-233 in Healthy Subjects

Clinical Pharmacology

Japan
Celgene

Completed

A Phase 1 Open-Label Study to Evaluate the Effect of CYP450 and P-gp Inhibition and Induction on the Pharmacokinetics of Pomalidomide (CC-4047) in Healthy Male Subjects (DDI)

Healthy | Pharmacology, Clinical

United States
Celgene

Completed

A Phase 1 QT Study in Healthy Male Subjects (QT/QTc)

Clinical Pharmacology, Healthy Volunteer Study

United States
Celgene

Completed

Study to Evaluate Pharmacokinetics of Single Oral Doses of Formulated and Non-Formulated CC-122, and Food Effect Study

Clinical Pharmacology, Healthy Male Volunteer Study

United States
Bayer

Completed

Effect of Riociguat on Bone Metabolism

Pharmacology, Clinical

Germany
Bayer

Completed

Bioequivalence Trial to Prove Equal Blood Concentrations of Two Different Fluconazole Formulations (Orca)

Pharmacology, Clinical

Germany
Bayer

Completed

Bioequivalence Study: 2 mg Estradiol Valerate (EV) and 3 mg Dienogest (DNG) Without and With Levomefolate Calcium

Pharmacology, Clinical

Germany
Bayer

Completed

A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufacturers Under Fasted Conditions in Healthy Adult Subjects

Clinical Pharmacology

United States
Bayer

Terminated

Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose in Participants With Liver Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Pharmacology, Clinical

Germany
Bayer

Completed

Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight

Clinical Pharmacology

Germany
Celgene

Completed

Study to Evaluate Pharmacokinetics of Pomalidomide in Hepatically Impaired Males

Clinical Pharmacology, Healthy Volunteer Study

United States
Cardurion Pharmaceuticals, Inc.

Completed

Effect of Coadministration of Itraconazole on the Pharmacokinetics of CRD-740

Cardiovascular Diseases | Heart Failure | Pharmacokinetics | Clinical Pharmacology

United States
Bayer

Completed

A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects Under Fed Conditions

Clinical Pharmacology

United States
Bayer

Completed

A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufactuers Under Fed Conditions in Healthy Adult Subjects

Clinical Pharmacology

United States
Bayer

Terminated

Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose of 10 mg Immediate Release Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Pharmacology, Clinical

Germany
Bayer

Completed

Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Clinical Pharmacology

Germany
Hanmi Pharmaceutical Company Limited

Completed

Single Ascending Dose Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM15912 in Healthy Korean Subjects

Pharmacology

Korea, Republic of
Janssen Research & Development, LLC

Completed

A Study to Assess the Effect of Timing of Food Intake on the Pharmacokinetics of Abiraterone Following Single-Dose Administration of Abiraterone Acetate Tablets in Healthy Caucasian and Japanese Men

Pharmacology

United States
Hanmi Pharmaceutical Company Limited

Completed

A First-in-Human, Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HM15136 in Healthy Subjects

Pharmacology

Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Completed

Voriconazole Blood Levels and Toxicity

Pharmacology

United States
INSYS Therapeutics Inc

Completed

Fentanyl Sublingual Spray in Opioid Naive Participants

Pharmacology

United States
Johns Hopkins University
Canopy Growth Corporation

Recruiting

The Pharmacodynamics of Cannabinoid-Caffeine Combinations

Behavioral Pharmacology of Cannabinoids

United States
Seoul National University Hospital

Completed

Minto Model in Effect Site Mode for Target-Controlled Infusion of Remifentanil During Cardiopulmonary Bypass

Cardiopulmonary Bypass | Pharmacology | Anesthetics, Intravenous | Anesthetics

Korea, Republic of
Sinew Pharma Inc.

Recruiting

A Partial Randomized, Single-blind or Open-label, Dose-escalation With Multiple-dose Design Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With Panadol® and SafeTynadol® in Healthy Volunteers

Hepatitis | Pharmacology

Taiwan
National Aeronautics and Space Administration (NASA)

Completed

Optimize Astronaut Sleep Medication Efficacy and Individual Effects

Sleep | Cognition | Pharmacologic Actions
AstraZeneca

Completed

A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate (AZD3293DDI)

Healthy Volunteers | Pharmacologic Action

United States
Ankara University

Completed

The Effect of Case-Based Education on the Development of Nursing Students' Clinical Reasoning Skills

Critical Illness | Clinical Reasoning

Turkey
Vivoryon Therapeutics N.V.
Covance

Completed

Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole

Healthy Volunteers | Pharmacologic Action

United Kingdom
Johns Hopkins University
Substance Abuse and Mental Health Services Administration (SAMHSA)

Recruiting

Comparative Pharmacokinetic and Pharmacodynamic Effects of Delta-8 and Delta-9 THC

Behavioral Pharmacology of Cannabis

United States
CardioDex
Sheba Medical Center

Withdrawn

Hemostatic Closure of Femoral Artery Access Site, Using the QuickClose Design 9 System

Coagulation | Therapeutic Uses | Pharmacologic Actions

Israel
Institut National de la Santé Et de la Recherche...
FUJIFILM Toyama Chemical Co., Ltd.

Recruiting

Evaluation of Tolerance and Pharmacokinetic Profile of High Doses of Favipiravir in Healthy Volunteers (FAVIDOSE)

Infectious Disease | Pharmacology

France
Walter Reed Army Institute of Research (WRAIR)

Completed

Genetic Variability in CYP2D6 in U.S Active Duty Population

Pharmacologic Action

United States
AstraZeneca

Completed

Relative Bioavailability Study to Assess Two Solid Formulations Compared to an Oral Solution of AZD3293 in Healthy Male and Non-Fertile Female Subjects (BA)

Healthy Volunteers | Pharmacologic Action

United States
Kaohsiung Medical University Chung-Ho Memorial...

Enrolling by invitation

The Effect of Proactive Clinical Ethics Consultations on End-of-life Care of the Critically Ill in the Intensive Care Settings

Proactive Clinical Ethics Consultation | the Critically Ill

Taiwan
Johns Hopkins University

Completed

Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Psilocybin | Therapeutic Uses | Psychotropic Drugs | Hallucinogens | Pharmacologic Actions | Central Nervous System Agents

United States
Johns Hopkins University
Canopy Growth Corporation

Recruiting

Pharmacokinetics and Pharmacodynamics of CHI-914 in Healthy Participants

Behavioral Pharmacology of Cannabis

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA); RTI International; National Institute...

Completed

Differences in Cannabis Impairment and Its Measurement Due to Route of Administration

Behavioral Pharmacology of Cannabis

United States
Cairo University

Not yet recruiting

Evaluation of Marginal, Internal Adaptation and Clinical Performance of Endo-crowns Fabricated From Nano Hybrid and Lithium Di-silicate Ceramic Materials.

Clinical Fit and Clinical Performance

3

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