Clinical Trials on Clostridium

Total 536 results

Prolacta Bioscience

Terminated

A Study of Safety of PBCLN-003 Following Antibiotic Therapy in Subjects With C.Difficile-associated Diarrhea

Clostridium Difficile Diarrhea

United States
RenJi Hospital

Recruiting

Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD Patients

Inflammatory Bowel Diseases | Microtia | Clostridium Difficile Infections

China
Genzyme, a Sanofi Company

Terminated

A Study to Assess the Safety, Tolerability, Effectiveness and Absorption of Exodif™ Tablets in Clostridium Difficile-associated Diarrhea

Diarrhea | Enterocolitis, Pseudomembranous | Clostridium Difficile

United States
Brigham and Women's Hospital
Icahn School of Medicine at Mount Sinai; The Miriam Hospital; Indiana University

Completed

The ICON Study: Outcomes After FMT for Patients With IBD and CDI

Inflammatory Bowel Diseases | Clostridium Difficile Infection

United States
Brigham and Women's Hospital

Active, not recruiting

ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDI (ICON-2)

Inflammatory Bowel Diseases | Clostridium Difficile Infection

United States
Michael E. DeBakey VA Medical Center

Suspended

Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy (loperamide)

Clostridium Difficile | Antibiotic-Associated Diarrhea

United States
National Institute of Allergy and Infectious Diseases...

Completed

Phase I Trial of a Single Dose of CRS3123

Clostridium Difficile Colitis

United States
University of Pennsylvania
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTs

Dysbiosis | Clostridium Difficile | Antibiotic-Associated Colitis | Pet-Human Bonding

United States
University Hospital of Cologne
Charite University, Berlin, Germany; University Hospital Tuebingen; University... and other collaborators

Completed

Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives (ABSOLUTE)

Clostridium Difficile Infection | Nosocomial Infection | VRE Infection | MRGN Bacteria

Germany
Beth Israel Deaconess Medical Center

Completed

Pathogenic Mechanisms in C Diff Infection and Colitis

Clostridium Difficile Infection

United States
Michael E. DeBakey VA Medical Center
Baylor College of Medicine

Completed

Vancomycin vs. Nitazoxanide to Treat Recurrent C. Difficile Colitis

Clostridium Enterocolitis | Pseudomembranous Colitis | Antibiotic-Associated Colitis

United States
Michael E. DeBakey VA Medical Center
Baylor College of Medicine

Completed

Association Between Response to Treatment of C. Diff Colitis and Anti-C.Diff Toxin Antibody

Clostridium Enterocolitis | Pseudomembranous Colitis | Antibiotic-Associated Colitis

United States
Changchun BCHT Biotechnology Co.
The First Affiliated Hospital of Yunnan University of Traditional Chinese... and other collaborators

Not yet recruiting

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of the Fully Human Anti-tetanus Toxin Monoclonal Antibody A82 / B86 Injection Combination Formulation

Clostridium Tetanus
Merck Sharp & Dohme LLC

Completed

A Study of Ascending Single Doses of Surotomycin in Healthy Participants (MK-4261-008)

Clostridium Difficile Associated Diarrhea (CDAD)
Merck Sharp & Dohme LLC

Completed

A Study of Ascending Multiple Doses of Oral Surotomycin in Healthy Participants (MK-4261-009)

Clostridium Difficile Associated Diarrhea (CDAD)
Bernhard Nocht Institute for Tropical Medicine
German Federal Ministry of Education and Research

Terminated

Probiotic Saccharomyces Boulardii for the Prevention of Antibiotic-associated Diarrhoea (SacBo)

Diarrhea | Antibiotic-associated Diarrhea | Clostridium Difficile

Germany
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Improved Adherence to C. Difficile Isolation Protocols Through Improved Education Methods

Bacterial Infection | Clostridium Difficile

United States
Genzyme, a Sanofi Company

Completed

A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea

Clostridium Enterocolitis | Pseudomembranous Colitis

United States, Canada, Puerto Rico
St Marina University Hospital, Varna, Bulgaria

Completed

Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children (AADreuter)

Gastroenteritis | Clostridium Difficile Infection | Antibiotic Associated Diarrhea

Bulgaria
University of Michigan
Wayne State University; Henry Ford Health System; Agency for Healthcare Research... and other collaborators

Completed

Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection

Clostridium Difficile Infection | Healthcare Associated Infection | Infection Due to Multidrug Resistant Bacteria

United States
Hospital Universitario de Valme

Recruiting

Natural History of Clostridioides Difficile Infection

Clostridium Difficile Infection | Nosocomial Infection | Health Care Associated Infection

Spain
Herbert DuPont, MD

Available

Fecal Microbiota Transplantation (FMT): PRIM-DJ2727

Recurrent Clostridium Difficile Infection | Multidrug-resistant Klebsiella Pneumoniae Urinary Tract Infection
Dr. Reddy's Laboratories Limited
Reliance Clinical Research Services (Navi Mumbai, India)

Completed

A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis

Clostridium Difficile Associated Diarrhea

India
McMaster University
The Physicians' Services Incorporated Foundation

Completed

Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment

Antibiotic-Associated Diarrhea | Clostridium Enterocolitis | Pseudomembranous Colitis | Pseudomembranous Enterocolitis | Pseudomembranous Enteritis

Canada
South Shore Hospital

Withdrawn

Probiotics in Hospitalized Patients Study

Antibiotic Associated Diarrhea | Clostridium Difficile Associated Diarrhea
GlaxoSmithKline

Completed

Safety and Immunogenicity Study of GSK's Clostridium Difficile Vaccine 2904545A When Administered in Healthy Adults Aged 18-45 Years and 50-70 Years

Clostridium Infections

Belgium
Romark Laboratories L.C.

Terminated

Study of Nitazoxanide in the Treatment of Clostridium Difficile-associated Disease

Clostridium Infections

United States
Sanofi

Completed

Safety, Tolerability, and Immunogenicity Study of a Clostridium Difficile Toxoid Vaccine in Healthy Adult Volunteers

Clostridium Infections
University of Pittsburgh

Completed

Clinical Outcomes of Patients With Clostridium Difficile Associated Disease Attributable to Diverse tcdC Genotypes

Clostridium Infections

United States
Stony Brook University

Completed

Fecal Microbial Transplantation for C. Difficile and/or Ulcerative Colitis or Indeterminate Colitis (FMT)

Ulcerative Colitis | Clostridium Difficile Infection | Indeterminate Colitis

United States
University of Pittsburgh
Bayer; Shadyside Hospital Foundation

Terminated

IVIG Versus Placebo for the Treatment of Patients With Severe C-Diff

Clostridium Difficile-associated Diarrhea (CDAD)

United States
MassBiologics
Medarex

Completed

Study of the Clinical Effectiveness of a Human Monoclonal Antibody to C. Difficile Toxin A and Toxin B in Patients With Clostridium Difficile Associated Disease

Clostridium Infections

United States, Canada
University of Cologne

Unknown

MicroTrans - A Multicenter Registry of Fecal Microbiota Transplantation (MicroTrans)

Clostridium Infections

Germany
Sanofi

Completed

Safety, Tolerability, and Immunogenicity of a Clostridium Difficile Toxoid Vaccine in Healthy Elderly Volunteers

Clostridium Infections

United States
AstraZeneca

Not yet recruiting

C.Difficile Observational Study

Clostridium Infections
MemorialCare Health System
Memorial Medical Center Foundation

Completed

Stool Transplant in Pediatric Patients With Recurring C. Difficile Infection

Clostridium Difficile Colitis

United States
University of Calgary
Canadian Institutes of Health Research (CIHR); Alberta Heritage Foundation... and other collaborators

Completed

Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial

Clostridium Difficile Infection | Nosocomial Infection | Vancomycin Resistant Enterococci Infection | Methicillin Resistant Staphylococcus Aureus Infection (MRSA)

Canada
Leiden University Medical Center

Recruiting

Clostridioides Difficile Colonisation (CloDiCo)

Clostridioides Difficile Infection

Netherlands
David Binion, MD
Merck Sharp & Dohme LLC

Recruiting

Prevention of Recurrent Clostridium Difficile Infection (CDI) in Patients With Inflammatory Bowel Disease (IBD).

Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis | C. Diff. Infections

United States
Rhode Island Hospital

Recruiting

Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis

Carpometacarpal Sprain | Thumb Sprain | Clostridium; Botulinum

United States
National Institute of Allergy and Infectious Diseases...

Completed

Study on the Safety and Immunogenicity of Boostrix Vaccine in Pregnant Malian Women and Their Infants

Pertussis | Tetanus | Diphtheria | Diphtheria Immunisation | Tetanus Immunisation | Clostridium Difficile Immunisation

Mali
Optimer Pharmaceuticals LLC

Completed

PAR-101/OPT-80 Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Diarrhea | Clostridium Infections

United States, France, United Kingdom, Belgium, Spain, Canada, Germany, Italy, Sweden
Bausch Health Americas, Inc.

Completed

A Trial to Compare Xifaxan to Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)

Diarrhea | Clostridium Infections

United States
Assistance Publique Hopitaux De Marseille

Unknown

Digestive Microbiota Transplant

Antibiotic Resistant Infection | Clostridium Difficile | Chronic Diarrhea of Unknown Origin

France
Optimer Pharmaceuticals LLC

Completed

Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018)

Diarrhea | Clostridium Infections
Turku University Hospital
Helsinki University Central Hospital; Satakunta Central Hospital; Päijät-Häme...

Recruiting

FMT in Initial CDI (FinCDI)

Clostridioides Difficile Infection

Finland
Bio-K Plus International Inc.
JSS Medical Research Inc.

Completed

Efficacy and Safety of BIO-K + CL1285 in Prevention of Antibiotic-associated Diarrhea in Hospitalized Adult Patients

Diarrhea | Clostridium Infections

Canada
University of Alberta
University of Calgary

Completed

FMT Delivered by Capsule Versus Colonoscopy for Recurrent C. Diff

Enterocolitis Clostridium Difficile Recurrent

Canada
Toi Labs, Inc.

Completed

Creation of an E-toileting Log Through Classification of the Physical Properties of Stool and Urine Using TrueLoo™

Urinary Tract Infections | Clostridium Difficile Infection | Gastrointestinal Disease | GastroIntestinal Bleeding | Infectious Diarrhea

United States
University of Rochester

Terminated

Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy (Abx)

Urinary Tract Infection | Prostate Cancer | Clostridium Difficile

United States

Clinical Trials on Clostridium

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CROs in Gabon

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