Clinical Trials on Clostridium Difficile Colonization

Total 1181 results

Hamilton Health Sciences Corporation

Recruiting

Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients (Decency-RCT)

Clostridium Difficile Diarrhea | Clostridium Difficile Colonization

Canada
Region Skane
Lund University

Terminated

Probiotics for Reduction of Infections With Clostridium Difficile in Critically Ill Patients (ProbiEnt)

Clostridium Difficile Colonisation | Impact of Enteral Probiotics on Certain Lab Parameters

Sweden
Vedanta Biosciences, Inc.

Recruiting

VE303 for Prevention of Recurrent Clostridioides Difficile Infection (RESTORATiVE303)

Clostridium Difficile Infection Recurrence | Recurrent Clostridium Difficile Infection | Clostridium Difficile | Diarrhea Infectious | CDI | Clostridium Difficile Infections | Clostridioides Difficile Infection | C.Difficile Diarrhea | Clostridioides Difficile Infection Recurrence | C. Diff Infection

United States
University of Virginia
Imperial College London

Recruiting

Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT) (ACT)

Clostridium Difficile Infection | Clostridium Difficile Diarrhea | Clostridioides Difficile Infection | Clostridia Difficile Colitis

United States
University of Alberta
University of British Columbia; McGill University; University of Calgary

Active, not recruiting

Multicentre Blinded Comparison of Lyophilized Sterile Fecal Filtrate to Lyophilized Fecal Microbiota Transplant in Recurrent Clostridioides Difficile Infection

Clostridium Difficile Diarrhea | Clostridia Difficile Colitis

Canada
Vedanta Biosciences, Inc.

Completed

Phase 2 Study of VE303 for Prevention of Recurrent Clostridioides Difficile Infection (CONSORTIUM)

Clostridium Difficile Infection | Clostridium Difficile Infection Recurrence | Clostridium Difficile | CDI | Clostridioides Difficile Infection | Clostridioides Difficile | Clostridioides Difficile Infection Recurrence

United States, Canada
University of Wisconsin, Madison
Mayo Clinic; Medical College of Wisconsin; Agency for Healthcare Research and... and other collaborators

Completed

Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection

Clostridium Difficile Infection | Recurrent Clostridium Difficile Infection | CDI | C.Difficile Diarrhea | C. Diff Colitis | C.Difficile Colitis

United States
Deinove

Recruiting

An Exploratory, Open-Label, Oligo-Center Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravenous DNV3837 in Subjects With Clostridium Difficile Infection

Clostridium Difficile (C. Difficile)

United States, Canada
Hospital General Universitario Gregorio Marañon

Unknown

Clostridium Difficile Infection (CDI) in Hematologic Patients.

C.Difficile Diarrhea

Spain
University of Wisconsin, Madison
Agency for Healthcare Research and Quality (AHRQ)

Enrolling by invitation

FQ Restriction for the Prevention of CDI (FIRST)

Clostridium Difficile Infection | Clostridium Difficile | C Difficile Colitis

United States
University of Wisconsin, Madison
Agency for Healthcare Research and Quality (AHRQ)

Completed

The GRAFT Study: Gut RecolonizAtion by Fecal Transplantation (GRAFT)

Clostridium Difficile Infection | CDI | C.Difficile Diarrhea

United States
Microbiome Health Research Institute
Brown University; Tufts Medical Center; Indiana University; Edward Hospital

Terminated

Safety of FMT: OpenBiome Outcomes and Longitudinal Follow-up (STOOL) for Recurrent Clostridium Difficile Infection (STOOL)

Clostridium Difficile

United States
Seres Therapeutics, Inc.
Syneos Health

Completed

SER-109 Versus Placebo to Prevent Recurrent Clostridium Difficile Infection (RCDI) (ECOSPOR)

Clostridium Difficile

United States
Mikrobiomik Healthcare Company S.L.

Completed

Primary or Recurrent Clostridioides Difficile Infection Treatment With Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin

Recurrent Clostridium Difficile Infection | Primary Clostridium Difficile Infection

Spain
University of Alberta

Terminated

Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infection

Clostridium Difficile

Canada
McMaster University
St. Joseph's Healthcare Hamilton

Terminated

A Prospective Trial of Frozen-and-Thawed Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection

Clostridium Difficile

Canada
Astellas Pharma Europe Ltd.
Merck Sharp & Dohme LLC

Completed

A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population (EXTEND)

Clostridium Difficile

Greece, Spain, Russian Federation, Denmark, Austria, Belgium, Croatia, Czechia, Finland, France, Germany, Hungary, Ireland, Italy, Poland, Portugal, Romania, Slovenia, Sweden, Switzerland, Turkey, United Kingdom
University of Pennsylvania

Terminated

Penn Microbiome Therapy (PMT) for Severe-Clostridium Difficile Infection (CDI)

Severe Clostridium Difficile Infection | Severe-Complicated/Fulminant Clostridium Difficile Infection

United States
Pfizer

Completed

Clostridium Difficile Vaccine 2-Dose Versus 3-Dose Study

Clostridium Difficile Associated Disease

United States
MJM Bonten
Universiteit Antwerpen; Universitätsklinikum Köln; Da Volterra

Completed

AssessmeNT of the Incidence of Clostridium Difficile Infections in Hospitalized Patients on Antibiotic TrEatment (ANTICIPATE)

Clostridium Difficile

Germany, Spain, France, Greece, Netherlands, Romania
Astellas Pharma Europe Ltd.
Cubist Pharmaceuticals LLC

Terminated

A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System (FREEDOM)

Clostridium Difficile

Spain, France, Germany, Greece, Denmark, Austria, Poland
Chinese University of Hong Kong

Unknown

Clostridium Difficile Virulence Mechanism Study (CDVM Study) (CDVM)

Clostridium Difficile Infection | Clostridium Difficile

Hong Kong
Medical University of Silesia

Unknown

Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain

Clostridium Difficile
Hvidovre University Hospital

Unknown

Rectal Bacteriotherapy, Fecal Microbiota Transplantation or Oral Vancomycin Treatment of Recurrent Clostridium Difficile Infections

Clostridium Difficile

Denmark
Pfizer

Completed

A Study To Investigate A Clostridium Difficile Vaccine In Healthy Adults Aged 50 to 85 Years, Who Will Each Receive 3 Doses Of Vaccine.

Clostridium Difficile Associated Disease

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Safety Registry of a Fecal Microbiota Transplant Cohort (COSMIC-FMT)

Clostridium Difficile Infections

France
University of North Carolina, Chapel Hill
North Carolina Translational and Clinical Sciences Institute; North Carolina...

Completed

Fecal Microbiota Transplantation (FMT) in Clostridium Difficile Infection (CDI) Not Responding to Antibiotics (FMT)

Clostridium Difficile

United States
Pfizer

Completed

A Study To Investigate Two 3-dose Schedules Of A Clostridium Difficile Vaccine In Healthy Adults Aged 65 to 85 Years

Clostridium Difficile Associated Disease

United States
Pfizer

Completed

Evaluation of a 3-dose Vaccination Regimen With One of Three Ascending Dose Levels of Clostridium Difficile Vaccine With or Without Adjuvant in Healthy Adults Aged 50 to 85 Years

Clostridium Difficile Associated Disease

United States
Pfizer

Completed

Evaluation Of Clostridium Difficile Vaccine Lot Consistency In Healthy Adults 65 To 85 Years Of Age

Clostridium Difficile Associated Disease

United States
Pfizer

Completed

Clostridium Difficile Vaccine Safety, Tolerability, and Immunogenicity Study in Japanese Adults

Clostridium Difficile Associated Disease

Japan
Michael E Villarreal, MD
Merck Sharp & Dohme LLC

Terminated

Comparing the Effectiveness of IV Bezlotoxumab Versus Placebo in Decreasing Morbidity and Mortality in Patients With Fulminant C. Diff Requiring Surgery.

Clostridia Difficile Colitis | Clostridium; Sepsis

United States
Hospital Universitario Evangelico de Curitiba

Not yet recruiting

Treatment of CDI and Recurrence With Fecal Microbiota Transplant Using Promicrobioma

Clostridium Difficile Infections
University Health Network, Toronto

Terminated

Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin

Recurrent Clostridium Difficile Infection | Laboratory Confirmed Clostridium Difficile Infection

Canada
Jewish General Hospital

Terminated

Loop Ileostomy With Colonic Lavage for Fulminant Clostridium Difficile Colitis

Fulminant Clostridium Difficile Colitis

Canada
University Hospital Tuebingen

Unknown

Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile Colitis (TOCSIN)

Clostridium Difficile Infection | Clostridium Difficile

Germany
University of Minnesota

Recruiting

Dietary Optimization of Microbiome Recovery Following Fecal Microbiota Transplantation

Recurrent Clostridium Difficile Infection | Fecal Microbiota Transplant

United States
Alison Schneider

Terminated

Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients

Clostridium Difficile Diarrhea

United States
Vanderbilt University Medical Center
National Institutes of Health (NIH)

Terminated

PROCLAIM -- Misoprostol in the Prevention of Recurrent CDI Prevent Recurrence of Clostridium Difficile Infection With Misoprostol (PROCLAIM)

Clostridium Difficile

United States
Ascension Genesys Hospital

Unknown

Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe (COLITIS)

Clostridium Difficile Colitis

United States
Yara El Helou
Pharma M

Terminated

Probiotics in the Prevention of Antibiotic Induced Diarrhea and Clostridium Difficile Associated Diarrhea.

Diarrhea, Clostridium Difficile

Lebanon
Optimer Pharmaceuticals LLC

Completed

Safety, Tolerability, and Pharmacokinetics of Fidaxomicin in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)

Clostridium Difficile-associated Diarrhea
Hadassah Medical Organization

Withdrawn

Safety and Validation of Efficacy of Oral Administration of the Food Additive Colostrum Derived Anti Clostridium Difficile Antibodies

Clostridium Difficile-Associated Diarrhea

Israel
University of Sussex
Danone Institute International

Completed

Probiotics in Preventing Antibiotic Associated Diarrhoea Including Clostridium Difficile Infection (NU278)

Diarrhoea | Clostridium Difficile

United Kingdom
Sanofi

Terminated

Phase I Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study, Safety, Tolerability and Immunogenicity

Clostridium Difficile Infection | Clostridium Difficile Diarrhea
Astellas Pharma Europe B.V.
Merck Sharp & Dohme LLC

Completed

A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD) (SUNSHINE)

Clostridium Difficile-associated Diarrhea (CDAD)

United States, Belgium, Italy, Canada, France, Germany, Hungary, Poland, Romania, Spain
Roma Tre University
Merck Sharp & Dohme LLC

Unknown

Relationship Between C. Difficile Toxins' Serum Level With C. Difficile Infection

Clostridium Difficile Infection | Clostridium Difficile
Optimer Pharmaceuticals LLC

Completed

Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation (MK-5119-001) (DEFLECT-1)

Clostridium Difficile-Associated Diarrhea (CDAD)
The Cooper Health System

Unknown

Bezlotoxumab Efficacy and Tolerability in Cancer Patient

Clostridium Difficile Infection Recurrence
Copenhagen University Hospital, Hvidovre
University of Copenhagen

Not yet recruiting

Virus as Treatment of C. Difficile Infection (VISION) (VISION)

Clostridium Difficile Infections

Denmark

Clinical Trials on Clostridium Difficile Colonization

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CROs in Liberia

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