Clinical Trials on Congenital Hepatic Fibrosis

Total 17218 results

Odense University Hospital

Active, not recruiting

Alcohol Challenge On Liver and Gut Measured by Liver Vein Catheterization. A Pathophysiological Intervention Trial

Alcohol-Induced Disorders | Liver Fibroses

Denmark
Rigshospitalet, Denmark

Completed

Cerebral Microdialysis in Patients With Fulminant Hepatic Failure

Fulminant Hepatic Failure

Denmark
University Medical Center Groningen

Completed

Non-invasive Measurement of Hemoglobin Concentration With Pulse Co-oximetry

Elective Hepatic Resection

Netherlands
Sanofi

Completed

A Pharmacokinetic and Tolerability Study of Fexinidazole in a Single Oral Dose in Adult Participants With Mild and Moderate Hepatic Impairment

Hepatic Function Abnormal

Bulgaria, France
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Belgium
Sanofi

Terminated

Pharmacokinetics of Amcenestrant in Female Hepatic Impaired Participants as Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

Korea, Republic of, Germany
Case Comprehensive Cancer Center

Completed

Comparison of Yttrium-90 Absorbed Doses Using PET/CT Versus PET/MR Imaging for Hepatic Malignancies

Hepatic Malignancies

United States
NGM Biopharmaceuticals, Inc

Completed

Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function

Impaired Hepatic Function

United States
Tetraphase Pharmaceuticals, Inc.

Completed

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

Impaired Hepatic Function

United States
Monash University

Recruiting

PFOX: Pulmonary Fibrosis Ambulatory Oxygen Trial (PFOX)

Fibrotic Interstitial Lung Disease

Australia
Peking Union Medical College Hospital

Unknown

Functional-three-dimensional Reconstruction of Liver by 99MTc-GSA-SPECT Scan (GSA)

Cirrhosis | Hepatic Carcinoma

China
CymaBay Therapeutics, Inc.

Recruiting

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Hepatic Impairment | Compensated Cirrhosis | Primary Biliary Cholangitis

Korea, Republic of, United States, Spain, United Kingdom
National Taiwan University Hospital

Completed

Prediction of Hepatic Fibrosis in Patients With Chronic Hepatitis C by Biochemical and Duplex Doppler Indices

Cirrhosis | Chronic Hepatitis C | Hepatic Fibrosis

Taiwan
Genfit

Completed

Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients

Liver Diseases | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
Acerta Pharma BV
AstraZeneca

Completed

Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite

Hepatic Insufficiency | Healthy Subjects | Hepatic Impairment

United States
Fuzhou General Hospital

Unknown

The Plasma Diafiltration Therapy of Hepatic Failure

Hepatic Failure | Plasma Exchange

China
Taisho Pharmaceutical Co., Ltd.

Completed

A Pharmacokinetic Study of TS-142 in Patients With Hepatic Impairment

Patients With Mild or Moderate Hepatic Impairment

Japan
RenJi Hospital

Unknown

Clinical and Basic Study for Pediatric Liver Transplantation (CBSPLT)

Metabolic Disorders | Biliary Atresia | Hepatic Tumors | Fulminant Liver Failure

China
The University of Texas Medical Branch, Galveston

Terminated

Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure

Acute and Chronic Hepatic Failure With Developing Coma

United States
Postgraduate Institute of Medical Education and...

Recruiting

20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension

Acute-On-Chronic Liver Failure | Shock, Septic | Cirrhosis, Liver | Shock Hypovolemic

India
Xiao Chen

Recruiting

Role of FAPI PET/MR Combined With Gadoxetate Disodium in Assessing Hepatic Malignancies

Hepatic Malignancies

China
M.D. Anderson Cancer Center

Recruiting

Stereotactic Liver Ablation Assisted With Intra-Arterial CT Hepatic Arteriography and Ablation Confirmation Software Assessment (STEREOLAB)

Liver Ablation | Hepatic

United States
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants

Healthy | Hepatic Impairment

United States
The University of Texas Health Science Center at...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Empagliflozin and Hepatic Glucose Metabolism

Hepatic Glucose Metabolism

United States
Institute for Clinical and Experimental Medicine

Completed

Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods

Hepatic Fat Content

Czechia
Centre Hospitalier Universitaire, Amiens

Completed

Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects. (PORTEAU)

Hepatic Flow Changes

France
Huazhong University of Science and Technology

Completed

MASIMO Radical 7 and Laboratory Measurement

Major Hepatic Surgery

China
University of California, San Diego

Recruiting

Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology as Reference

Nonalcoholic Steatohepatitis | Nonalcoholic Fatty Liver | Liver Inflammation | Liver Fibroses

United States
Polyganics BV
Genae

Completed

Safety and Performance of a Synthetic Tissue Sealant in Reducing Fluid Leakage in Hepatobiliary and Pancreatic Surgery (SHIELDS)

Pancreatectomy | Hepatic Resection

Germany
AstraZeneca

Completed

Open-label Study to Assess the Pharmacokinetics of NKTR-118 in Patients With Impaired Hepatic Function

Hepatic; Functional Disturbance

United States
Taiho Oncology, Inc.

Completed

Evaluating Patients With Impaired Hepatic Function

Impaired Hepatic Function

United States
Lisa M. Guay-Woodford
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource

Nephronophthisis | Joubert Syndrome | Bardet Biedl Syndrome | Autosomal Recessive Polycystic Kidney Disease | Congenital Hepatic Fibrosis | Hepato/Renal Fibrocystic Disease | Meckel-Gruber Syndrome | Caroli Syndrome | Oro-Facial-Digital Syndrome Type I | Glomerulocystic Kidney Disease

United States
University of Pennsylvania
Pennsylvania Department of Health

Recruiting

Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease

Cirrhosis, Liver | Muscle Loss | Physical Inactivity | End Stage Liver DIsease | Symptoms and Signs

United States
Clinical Hospital Colentina

Active, not recruiting

Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis (DYNACORD-AD)

Cirrhosis | Cardiomyopathies | Acute Liver Failure

Romania
Axcan Pharma

Completed

Pilot Study of Ursodesoxycholic Acid in Non-Alcoholic Steatohepatitis (URSONASH)

Serum Levels of ALAT Transaminases | Serum Markers for Fibrosis and Hepatic Inflammation

France
Astellas Pharma Europe B.V.

Completed

A Study to Investigate the Effect of Mirabegron (YM178) on Subjects With Mild or Moderate Hepatic Impairment Compared to Healthy Subjects

Healthy Subjects | Pharmacokinetics | Mild and Moderate Hepatic Impairment

Slovakia
Assistance Publique - Hôpitaux de Paris

Completed

The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure

Hepatitis

France
Atea Pharmaceuticals, Inc.

Recruiting

Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Volunteer

United States
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

An Investigational Study of SHR3680 in Participants With Mild to Moderate Liver Impairment and Healthy Participants

Hepatic Impairment | Healthy Participants

China
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Safety and Pharmacokinetics of Fluzoparib in Healthy Subjects and Those With Impaired Liver Function

Healthy Subjects | Hepatic Impairment

China
Jiangsu HengRui Medicine Co., Ltd.

Unknown

An Investigational Study of SHR6390 in Participants With Mild to Moderate Liver Impairment and Healthy Participants

Hepatic Impairment | Healthy Participants
Klinikum Ludwigshafen

Completed

Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function

Inflammatory Response | Hepatic Function

Germany
Tanta University

Recruiting

Clinical Study Evaluating Efficacy, Safety and Molecular Mechanism of Both N-acetylcysteine and Pentoxifylline Supplementation in Patients With Hepatic and Post Hepatic Jaundice

Hepatic and Post Hepatic Jaundice

Egypt
Merck Sharp & Dohme LLC

Completed

A Study to Assess Pharmacokinetics of Preladenant in Participants With Chronic Hepatic Impairment (P06513)

Chronic Hepatic Impairment
Lantheus Medical Imaging

Completed

Prospective Evaluation of the Incidence of NSF in Patients With Kidney Disease Undergoing MR

Nephrogenic Systemic Fibrosis

United States
Children's Hospital Medical Center, Cincinnati

Recruiting

Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease

Sickle Cell Disease | Diffuse Myocardial Fibrosis

United States
Conatus Pharmaceuticals Inc.

Terminated

Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF

Liver Cirrhosis | Acute on Chronic Hepatic Failure | Acute Liver Failure | Acute Alcoholic Hepatitis

United States, United Kingdom
Daiichi Sankyo, Inc.

Completed

Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy Participants

Moderate Hepatic Impairment

United States
Post Graduate Institute of Medical Education and...

Not yet recruiting

MASLD in Primary Hypothyroidism and Efficacy of Dapaglifozin (SHIELD)

Non-Alcoholic Fatty Liver Disease | Hepatic Steato-Fibrosis

India

Clinical Trials on Congenital Hepatic Fibrosis

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