Clinical Trials on Constitutional Mismatch Repair Deficiency (CMMRD)
Total 377 results
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The Hospital for Sick ChildrenBristol-Myers SquibbTerminatedRefractory or Recurrent Hypermutated Malignancies | Biallelic Mismatch Repair Deficiency (bMMRD) Positive PatientsUnited States, France, Canada, Australia, Israel
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Assistance Publique - Hôpitaux de ParisNot yet recruiting
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Yu jirenRecruitingAdenocarcinoma of the Stomach | Mismatch Repair Deficiency | Adenocarcinoma of Esophagogastric JunctionChina
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Bristol-Myers SquibbActive, not recruitingMicrosatellite Stable Colorectal Cancer | Mismatch Repair Proficient Colorectal Cancer | Microsatellite Unstable Colorectal Cancer | Mismatch Repair Deficient Colorectal CancerUnited States, Australia, Belgium, Canada, Ireland, Italy, Spain, France
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Apollomics (Australia) Pty. Ltd.Novotech (Australia) Pty Limited; Apollomics Inc. (formerly CBT Pharmaceuticals...CompletedSolid Tumor | Microsatellite Instability | Mismatch Repair Deficiency | Cancer of Unknown Primary SiteAustralia
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National Center for Tumor Diseases, HeidelbergAstraZeneca; German Cancer Research Center; PharmaMarCompletedCancers With DNA Repair-DeficiencyGermany
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Peking Union Medical College HospitalRecruitingColon Cancer | Immunotherapy | Mismatch Repair DeficiencyChina
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Yu jirenRecruitingAdenocarcinoma of the Stomach | Adenocarcinoma of Esophagogastric Junction | Proficient Mismatch RepairChina
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VA Office of Research and DevelopmentMerck Sharp & Dohme LLCRecruitingMetastatic Castration Resistant Prostate CancerUnited States
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Sun Yat-sen UniversityThe Second Affiliated Hospital of Kunming Medical UniversityCompletedColorectal Cancer Metastatic | Microsatellite Instability High | Mismatch Repair DeficiencyChina
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University Health Network, TorontoAstraZenecaActive, not recruitingPancreatic Adenocarcinoma | Leiomyosarcoma | Mismatch Repair Proficient Colorectal CancerCanada
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University of British ColumbiaUnknownOxidative Stress | Sleep Quality | DNA Damage Repair Deficiency
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University of Colorado, DenverNational Cancer Institute (NCI); Cancer League of ColoradoWithdrawnColorectal Cancer | Microsatellite Instability High | Mismatch Repair DeficiencyUnited States
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Third Affiliated Hospital, Sun Yat-Sen UniversityRecruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Sun Yat-sen UniversityRecruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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LiuYingNot yet recruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Sun Yat-sen UniversityRecruitingColorectal Cancer Stage IV | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Idience Co., Ltd.Active, not recruitingSolid Tumors | Homologous Recombination Deficiency | Homologous Recombination Repair Gene MutationKorea, Republic of
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BeiGeneRecruitingUnresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal CancerChina, United States, Australia, Puerto Rico
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)CompletedHigh-Frequency Microsatellite Instability | Mismatch Repair Gene Mutation | Mutation-Negative Lynch Syndrome | Mutation-Positive Lynch SyndromeUnited States
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WellSpan HealthActive, not recruitingEndometrial Hyperplasia | Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Mismatch Repair DeficiencyUnited States
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Rottapharm BiotechAgenus Inc.Active, not recruitingSolid Tumor | Metastatic Microsatellite-stable Colorectal Cancer | Mismatch Repair Protein Proficient | Refractory Metastatic Colorectal CancerItaly
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Replimune Inc.RecruitingCancer | NSCLC | Melanoma (Skin) | Microsatellite Instability | Cutaneous Melanoma | Mismatch Repair Deficiency | Non-melanoma Skin CancerUnited States, Spain, France, United Kingdom, Germany
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National Cancer Institute (NCI)RecruitingLynch Syndrome | Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Refractory Ependymoma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Refractory Diffuse Intrinsic Pontine Glioma | Recurrent Brain Neoplasm | Refractory Brain Neoplasm | Constitutional...United States, Canada
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National Cancer Institute (NCI)WithdrawnAdvanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma
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National Cancer Institute (NCI)CompletedHematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Plasma Cell MyelomaUnited States
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Medical University InnsbruckUnknown
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Assistance Publique - Hôpitaux de ParisRecruitingArtemis (DCLRE1C ) Deficient Severe Combined ImmunodeficiencyFrance
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Zhejiang Cancer HospitalRecruitingColorectal Cancer Metastatic | Microsatellite Stable | Mismatch Repair-proficientChina
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National Cancer Institute (NCI)WithdrawnHematopoietic and Lymphoid Cell Neoplasm | Lynch Syndrome | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central... and other conditionsUnited States, Canada
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National Institute of Allergy and Infectious Diseases...Enrolling by invitationSevere Combined Immune Deficiency (SCID)United States
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Federal Research Institute of Pediatric Hematology...RecruitingNijmegen Breakage SyndromeRussian Federation
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Federal Research Institute of Pediatric Hematology...RecruitingNijmegen Breakage SyndromeRussian Federation
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University of California, Los AngelesRecruitingAdenosine Deaminase Severe Combined Immune DeficiencyUnited States
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Virginia Commonwealth UniversityRecruitingEndometrial Cancer | Recurrent Endometrial Cancer | Mismatch Repair-ProficientUnited States
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Emory UniversityCompletedSevere Combined Immunodeficiency | T-Cell Immune Deficiency DiseasesUnited States
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Asan Medical CenterRecruitingBiliary Tract Cancer | DNA Damage Repair DeficiencyKorea, Republic of
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Chiesi Farmaceutici S.p.A.CompletedSevere Combined Immunodeficiency | Adenosine Deaminase DeficiencyUnited States
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Seattle Institute for Biomedical and Clinical ResearchVA Puget Sound Health Care System; Prostate Cancer FoundationTerminatedMetastatic Prostate Carcinoma | Recurrent Prostate Carcinoma | Stage IV Prostate Cancer | Hormone-Resistant Prostate CancerUnited States
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Rutgers, The State University of New JerseyNational Cancer Institute (NCI)RecruitingGastric Adenocarcinoma | Epstein-Barr Virus Positive | Mismatch Repair Protein Deficiency | Stage IB Gastric Cancer AJCC v7 | Stage II Gastric Cancer AJCC v7 | Stage IIA Gastric Cancer AJCC v7 | Stage IIB Gastric Cancer AJCC v7 | Stage III Gastric Cancer AJCC v7 | Stage IIIA Gastric Cancer AJCC v7 | Stage... and other conditionsUnited States
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Great Ormond Street Hospital for Children NHS Foundation...Completed
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Leadiant Biosciences, Inc.CompletedSevere Combined Immunodeficiency | ADA-SCID | Adenosine Deaminase DeficiencyUnited States
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Floor BackesTerminatedLynch Syndrome | Recurrent Endometrial Carcinoma | Recurrent Endometrial Clear Cell Adenocarcinoma | Recurrent Endometrial Cancer | Metastatic Endometrial Cancer | Mismatch Repair Deficiency | Recurrent Uterine Corpus CarcinosarcomaUnited States
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Fondazione TelethonCompletedSevere Combined Immunodeficiency Due to ADA DeficiencyItaly
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University of California, Los AngelesGreat Ormond Street Hospital for Children NHS Foundation TrustEnrolling by invitationAdenosine Deaminase Deficiency | Severe Combined Immunodeficiency (SCID)United States, United Kingdom
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Fondazione TelethonActive, not recruitingSevere Combined Immunodeficiency Due to ADA DeficiencyItaly
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Great Ormond Street Hospital for Children NHS Foundation...Orchard TherapeuticsCompletedSevere Combined Immunodeficiency Due to ADA DeficiencyUnited Kingdom
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University of California, Los AngelesWithdrawnSevere Combined Immunodeficiency Due to ADA DeficiencyUnited States
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Leiden University Medical CenterZonMw: The Netherlands Organisation for Health Research and Development; Horizon...RecruitingSevere Combined Immunodeficiency Due to RAG1 DeficiencySpain, Netherlands, Italy, Poland, Australia, Turkey, United Kingdom
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University of California, Los AngelesOrchard Therapeutics; California Institute for Regenerative Medicine (CIRM)CompletedSevere Combined Immunodeficiency Due to ADA DeficiencyUnited States